Bioactive Phenolics of Hyoscyamus muticus L. Subsp. Falezlez: A Molecular and Biochemical Approach to Antioxidant and Urease Inhibitory Activities

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 370 - 370

Published: Jan. 4, 2025

This study examines the chemical composition, antioxidant properties, and urease inhibitory effects of Hyoscyamus muticus L. subsp. falezlez (Coss.) Maire. Using LC-ESI-MS/MS, 19 distinct phenolic compounds were identified, with chlorogenic acid being most abundant. The ethanol extract demonstrated notable activity, highlighting its potential for therapeutic use. Urease inhibition assays revealed a remarkable 91.35% by H. extract, an IC50 value 5.6 ± 1.20 μg/mL, indicating promising role in addressing conditions linked to activity. Molecular docking studies further investigated interaction between urease, identifying hyperoside as leading candidate, binding energy −7.9 kcal/mol. Other compounds, such rutin, luteolin, apigenin, kaempferol, hesperetin, acid, rosmarinic also significant affinities, suggesting their disrupt function. These findings highlight source natural bioactive offering avenues development novel treatments urease-related disorders oxidative stress.

Language: Английский

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Preliminary Data on Silybum marianum Metabolites: Comprehensive Characterization, Antioxidant, Antidiabetic, Antimicrobial Activities, LC-MS/MS Profiling, and Predicted ADMET Analysis

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 13 - 13

Published: Jan. 3, 2025

Silybum marianum extract, obtained via microwave-enhanced extraction, was evaluated for its antioxidant, antidiabetic, and antimicrobial activities to explore therapeutic potential. The extraction performed using techniques, LC-MS/MS employed profile the metabolites in extract. Total phenolic flavonoid contents were quantified spectrophotometric methods. Antioxidant activity assessed DPPH, ABTS, CUPRAC, Phenanthroline, FRAP assays. Enzyme inhibition assays conducted evaluate antidiabetic against α-glucosidase α-amylase. Antimicrobial determined disc diffusion method, silico ADMET drug-likeness analyses key metabolites. extract contained 251.2 ± 1.2 mg GAE/g of total phenolics 125.1 1.6 QE/g flavonoids, with 33 identified, including acids, tannins, flavolignans. Strong antioxidant observed, IC50 values 19.2 2.3 μg/mL (DPPH), 7.2 1.7 (ABTS), 22.2 (CUPRAC), 35.2 1.8 (Phenanthroline), 24.1 (FRAP). Antidiabetic effects significant, 18.1 (α-glucosidase) 26.5 1.3 (α-amylase). demonstrated zones 8.9 1.1 mm (Bacillus subtilis), 12.6 (Escherichia coli), 8.2 (Fusarium oxysporum), 9.2 (Aspergillus niger). In showed high absorption, favorable metabolism excretion, minimal toxicity, no hERG channel or hepatotoxicity. comprehensive results highlight significant S. suggesting potential preventive applications.

Language: Английский

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From Green Chemistry to Healthy Environments: Silver Nanoparticles as a Dual Antioxidant and Antibacterial Agents for Advancing Biomedicine and Sustainable Wastewater Treatment

Bioengineering, Journal Year: 2024, Volume and Issue: 11(12), P. 1205 - 1205

Published: Nov. 28, 2024

The green synthesis of silver nanoparticles (AgNPs) using plant extracts is an eco-friendly method with potential for biomedical and environmental applications. This study aims to synthesize (SO-AgNPs) Salvia officinalis L. extract evaluate their antioxidant antibacterial properties, positioning them as candidates applications in sustainable biomedicine wastewater treatment. S. was used AgNPs under optimized conditions, a 10% extract/AgNO₃ ratio reaction time 180 min. SO-AgNPs were characterized ATR-FTIR, XRD, SEM, DLS, Zeta analysis. activity the evaluated ABTS+• DPPH• radical scavenging assays. Antibacterial tested against 11 bacterial strains bacteria isolated from industrial effluent, minimal inhibitory concentrations (MIC) determined both SO-AgNPs. demonstrated potent activity, IC₅₀ values 0.233 mg/mL 0.305 assay, 0.173 0.185 assay SO-AgNPs, respectively. testing showed MIC 0.25 between 3.12 6.25 E. coli, P. aeruginosa, A. baumannii, MRSA, B. cereus, epidermidis. For 0.125 0.5 extract. highlights dual capabilities demonstrating use applications, including

Language: Английский

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Green Innovation: Multifunctional Zinc Oxide Nanoparticles Synthesized Using Quercus robur for Photocatalytic Performance, Environmental, and Antimicrobial Applications

Catalysts, Journal Year: 2025, Volume and Issue: 15(3), P. 256 - 256

Published: March 7, 2025

This study investigates the green synthesis of zinc oxide nanoparticles (ZnO NPs) using leaf extract as a natural reducing agent, evaluating their antimicrobial and photocatalytic properties. The were annealed at 320 °C 500 °C, effects concentration annealing temperature on structural, morphological, electronic properties systematically explored. X-ray diffraction (XRD) analysis confirmed hexagonal wurtzite structure ZnO, with crystallite size defect density being influenced by extract. Scanning electron microscopy (SEM) revealed formation smaller, spherical particles, increased aggregation observed higher concentrations. Fourier-transform infrared spectroscopy (FTIR) identified key functional groups, such hydroxyl C–O bonds, metal–oxygen vibrations. UV–Vis showed reduction in band gap energy an increase Urbach increased. activity ZnO NPs was evaluated against Gram-positive Gram-negative bacteria well Candida albicans, demonstrating significant antibacterial efficacy. Photocatalytic degradation studies methylene blue dye superior efficiency up to 74% for samples, particularly °C. research highlights potential green-synthesized wide range applications, including agents, water purification, environmental catalysis. It contributes advancement sustainable nanotechnology, offering promising solutions both technological ecological challenges.

Language: Английский

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A Novel Halophilic Bacterium for Sustainable Pollution Control: From Pesticides to Industrial Effluents

Water, Journal Year: 2025, Volume and Issue: 17(6), P. 888 - 888

Published: March 19, 2025

This study investigates the bioremediation potential of Marinobacter-hydrocarbonoclasticus SDK644, a strain that has been isolated from petroleum-contaminated environments, for degradation herbicide metribuzin and treatment slaughterhouse effluent. The strain’s bacterial growth capacity were assessed under varying conditions, including different concentrations, pH values, temperatures, inoculum sizes. demonstrated optimal at concentration 20 mg/L, with an optical density (OD600) 0.408 after 96 h. At this concentration, 80% chemical oxygen demand (COD) was reduced over 144 conditions M. hydrocarbonoclasticus SDK644 identified as 7 temperature 30 °C, where enzymatic activity efficiency maximized. Additionally, effluent showed significant reductions in organic pollution, COD biochemical (BOD5) decreasing by (from 1900 mg/L to 384 mg/L) 81% 1700 320 mg/L), respectively, within seven days. also facilitated ammonium removal promoted nitrification, indicating its suitability treating high-organic-load wastewater. Notably, visual transformation effluent, dark red color clear state, further highlighted process. research highlights adaptability wide range environmental biodegrading complex findings demonstrate sustainable solution mitigating pollution agricultural runoff, pesticide-contaminated water, industrial effluents.

Language: Английский

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Sustainable Removal of Basic Fuchsine and Methylene Blue Dyes Using Chicken Bone Biomass: Thermodynamics, Kinetics, and Insights from Experimental Studies and Decision Tree with Least Squares Boosting Predictive Modeling

Water, Journal Year: 2025, Volume and Issue: 17(7), P. 1053 - 1053

Published: April 2, 2025

This study addresses the dual challenges of water pollution and waste management by exploring valorization chicken bone biomass in native (NBio) calcined (CBio) forms as biosorbents for dye removal. Basic fuchsine (BF) methylene blue (MB) were selected model pollutants, adsorption was assessed under varying operational conditions. Characterization using Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) showed that calcination improved crystallinity, eliminated organic impurities, increased surface area (247 m2/g NBio vs. 370 CBio). Adsorption tests revealed higher performance CBio, with maximum capacities 100 mg/g 142.85 based on Langmuir isotherm, while 111 111.11 followed Freundlich model. kinetics indicated pseudo-second-order behavior, suggesting chemisorption. The possible interactions between dyes biosorbent are hydrogen bonding, electrostatic interactions, Lewis acid–base interactions. Thermodynamic analysis highlighted exothermic behavior endothermic, entropy-driven both processes being spontaneous. A decision tree Least Squares Boosting (DT_LSBOOST) provided accurate predictions (R2 = 0.9999, RMSE < 0.003) integrating key parameters. These findings promote a cost-effective, sustainable biosorbent, offering promising potential wastewater treatment environmental remediation.

Language: Английский

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Approximation of Oxygen Transfer Efficiency of Solid Jet Aerator Having Circular Opening with Kernel Function-Based Models and Random Forest Models

Iranian Journal of Science and Technology Transactions of Civil Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

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