CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin DOI Creative Commons
Mohammed G. Maslub, Nur Aizati Athirah Daud, Mahasen A. Radwan

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 10, 2024

A single nucleotide polymorphism (SNP) is a variation in the DNA sequence that results from alteration of genome. Atorvastatin used to treat hypercholesterolemia. It belongs class drugs called statins, which lower elevated levels total cholesterol (TC) and low-density lipoprotein (LDL-C). Research findings on associations between response atorvastatin genetic polymorphisms CYP3A4 CYP3A5 are inconclusive. The effects CYP3A4*1B (rs2740574 C/T) CYP3A5*3 (rs776746 T/C) therapy have not been previously studied among Egyptians.

Language: Английский

Efficacy and safety of inclisiran versus PCSK9 inhibitor versus statin plus ezetimibe therapy in hyperlipidemia: a systematic review and network meta-analysis DOI Creative Commons
Suyi Zhang, Lei Sun, Xinyu Xu

et al.

BMC Cardiovascular Disorders, Journal Year: 2024, Volume and Issue: 24(1)

Published: Nov. 9, 2024

Hyperlipidemia plays a crucial role in increasing the risk of cardiovascular diseases such as atherosclerosis. Recent studies have established that inclisiran positively influences lipid regulation. Nevertheless, its effectiveness comparison to conventional treatments is still questionable. Hence, methodical assessment and safety required. This research evaluates efficacy inclisiran, PCSK9 inhibitors, combination statins with ezetimibe treatment hyperlipidemia via network meta-analysis randomized controlled trials (RCTs). We performed an extensive search English-language publications PubMed, Medline, Embase, Cochrane Library databases until April 2024. conducted web-based reported accordance guidelines. selected percentage change low-density lipoprotein cholesterol (LDL-C), total (TC), triglycerides (TG), high-density (HDL-C) evaluation metrics incidence adverse events for analysis comparison. incorporated 33 involving 23,375 patients, evaluating three interventions regarding their effects on LDL-C, TC, TG, HDL-C, events. All improved over placebo. Inclisiran significantly reduced LDL-C compared (mean − 15.21, 95% CI [-25.19, -5.23]) but showed no significant difference from statin + ezetimibe. Surface under cumulative ranking curve (SUCRA) rankings placed highest reduction (26.2%). The was most efficacious triglyceride 17.2, [10.22, 24.19]; mean 15.61, [16.87, 24.35]). profiles were comparable across treatments. superior low frequency administration, appears promising treatment, particularly patients adherence issues or side other medications. CRD42024550852

Language: Английский

Citations

2
Role of Statins in Oral and Maxillofacial Surgery: A Literature Review DOI Open Access

S. Kanabar,

Deepankar Shukla, Nitin Bhola

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

In recent years, there has been a notable increase in interest the use of statins oral and maxillofacial surgery. The purpose this literature review was to look into effectiveness area. Using set keywords, thorough search electronic databases carried out, including PubMed, Scopus, Web Science, Excerpta Medica database (EMBASE), ProQuest. papers considered were just those published English language between January 2012 2024. Only human studies taken consideration; involving animals not. For final analysis that assessed dentistry, total 30 chosen. designs, sample sizes, materials employed experiments varied. According research, improve bone regeneration, have antiviral antibacterial qualities, work well as therapeutic adjuvant for treatment periodontal disease. indicates may be beneficial treating disease, promoting improving health context Nevertheless, more investigation is required completely comprehend function domain.

Language: Английский

Citations

1
Hypertension-Mediated Organ Damage in Relation to Severity of Chronic Low Back Pain in Hypertensive Patients DOI Creative Commons

Maciej Skrzypek,

Rafał Kolec,

Michał Słaboszewski

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2024, Volume and Issue: 11(9), P. 266 - 266

Published: Aug. 28, 2024

Chronic pain triggers a stress response, which results in increased blood pressure (BP). We investigated whether chronic low back (cLBP) hypertensive patients is associated with an risk of hypertension-related organ damage.

Language: Английский

Citations

0
CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin DOI Creative Commons
Mohammed G. Maslub, Nur Aizati Athirah Daud, Mahasen A. Radwan

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 10, 2024

A single nucleotide polymorphism (SNP) is a variation in the DNA sequence that results from alteration of genome. Atorvastatin used to treat hypercholesterolemia. It belongs class drugs called statins, which lower elevated levels total cholesterol (TC) and low-density lipoprotein (LDL-C). Research findings on associations between response atorvastatin genetic polymorphisms CYP3A4 CYP3A5 are inconclusive. The effects CYP3A4*1B (rs2740574 C/T) CYP3A5*3 (rs776746 T/C) therapy have not been previously studied among Egyptians.

Language: Английский

Citations

0