Triggerable Patches for Medical Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 11, 2024

Medical patches have garnered increasing attention in recent decades for several diagnostic and therapeutic applications. Advancements material science, manufacturing technologies, bioengineering significantly widened their functionalities, rendering them highly versatile platforms wearable implantable Of particular interest are triggerable designed drug delivery tissue regeneration purposes, whose action can be controlled by an external signal. Stimuli-responsive particularly appealing as they may enable a high level of temporal spatial control over the therapy, allowing precision possibility to adjust treatment according specific clinical personal needs. This review aims provide comprehensive overview existing extensive literature on patches, emphasizing potential diverse applications highlighting strengths weaknesses different triggering stimuli. Additionally, current open challenges related design use efficient such tuning mechanical adhesive properties, ensuring acceptable trade-off between smartness biocompatibility, endowing with portability autonomy, accurately controlling responsiveness stimulus maximizing efficacy, reviewed.

Language: Английский

Locomotion control of Cyborg insects by using ultra-thin, self-adhesive electrode film on abdominal surface

npj Flexible Electronics, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 13, 2025

Abstract Cyborg insects are living organisms combined with artificial systems, allowing flexible behavioral control while preserving biological functions. Conventional methods often electrically stimulate sensory organs like antennae and cerci but these invasive can impair vital This study shows a minimally approach using flexible, ultra-thin electrodes on the cockroach’s abdomen, avoiding contact primary organs. Using liquid evaporation for film adhesion provides biocompatible process excellent adhesive strength electrical durability. Body surface stimulating component structures formed by utilizing an insect’s natural movement showed higher stability than conventional methods. These enable effective of both turning straight-line movements. method maintains behavior enhancing cyborg functionality, extending potential applications.

Language: Английский

Enhancing Regeneration and Functionality of Excitable Tissues via Integrating Bioelectronics and Bioengineered Constructs

International Journal of Extreme Manufacturing, Journal Year: 2024, Volume and Issue: 7(2), P. 022004 - 022004

Published: Nov. 15, 2024

Abstract The inherent complexities of excitable cardiac, nervous, and skeletal muscle tissues pose great challenges in constructing artificial counterparts that closely resemble their natural bioelectrical, structural, mechanical properties. Recent advances have increasingly revealed the beneficial impact bioelectrical microenvironments on cellular behaviors, tissue regeneration, therapeutic efficacy for tissues. This review aims to unveil mechanisms by which electrical enhance regeneration functionality cells tissues, considering both endogenous cues from electroactive biomaterials exogenous stimuli external electronic systems. We explore synergistic effects these microenvironments, combined with structural guidance, using engineering scaffolds. Additionally, emergence micro/nanoscale bioelectronics has significantly broadened this field, facilitating intimate interactions between implantable across cellular, tissue, organ levels. These enable precise data acquisition localized modulation cell functionalities through intricately designed components according physiological needs. integration promises optimal outcomes, highlighting a growing trend developing living construct-bioelectronic hybrids restoring monitoring damaged Furthermore, we envision critical next-generation hybrids, focusing integrated fabrication strategies, development ionic conductive biomaterials, convergence biosensors.

Language: Английский