Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 102(12), P. 1425 - 1450
Published: Oct. 2, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 270, P. 132367 - 132367
Published: May 13, 2024
Language: Английский
Citations
7
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135357 - 135357
Published: Sept. 6, 2024
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132909 - 132909
Published: June 6, 2024
Language: Английский
Citations
4
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 8, 2025
Monitoring wound infection and providing appropriate treatment are crucial for achieving favorable outcomes. However, the time-consuming nature of laboratory culture tests may delay timely intervention. To tackle this challenge, a simple yet effective HDG hydrogel, composed hydrogen peroxide (H₂O₂), dopamine, GelMA polymer, is developed ultrafast detection Staphylococcus aureus (SA) infections. The hydrogel detects SA by exploiting its secreted catalase to catalyze H₂O₂, producing oxygen, which in turn accelerates polymerization colorless dopamine into deep brown polydopamine (PDA). bacterial process takes only 10 min with high sensitivity, results can be readily recognized naked eye or quantified using cell phone-based digital analysis. Moreover, provides dual antibacterial mechanism through chemical photothermal therapies via generated PDA, significantly improving clearance. In animal experiments, demonstrated promising capabilities monitoring eliminating bacteria, enhancing collagen deposition, reducing inflammation, promoting healing infected wounds. This multifunctional design offers an enzyme-responsive strategy rapid assessment management infections, simplifying evaluation facilitating development advanced dressings.
Language: Английский
Citations
0
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Abstract In order to improve the disadvantages of traditional hydrogels such as low mechanical strength and lack responsiveness, different types nanoparticles or nanostructures are added into hydrogel network through in situ polymerization, self‐assembly techniques, other strategies, giving a variety special properties, stimulation sensitivity, optical electrical reversibility. With development nano materials synthesis technology, nanocomposite have shown great potential drug delivery, tissue engineering, motion detection, wastewater treatment, been extensively studied recent years. This review comprehensively elucidates state‐of‐the‐art preparation strategies underlying response mechanisms diverse stimulus‐responsive hydrogels, spanning temperature, pH, humidity, electrical, light responses. It systematically dissects their applications biomedicine, environmental remediation, flexible sensing, composite phase change materials. Moreover, it delves future prospects challenges, emphasizing need for continuous innovation unlock full emerging fields address existing limitations.
Language: Английский
Citations
0
Journal of Cluster Science, Journal Year: 2024, Volume and Issue: 35(6), P. 2019 - 2037
Published: May 20, 2024
Abstract The natural physiological response to skin injury is wound healing. However, restore continuity, healing a complicated process that involves the collaboration of variety cell types and other mediators. This ultimately results in tissue regeneration restoration barrier function. Hydrogels are appealing dosage forms for biomedical regenerative medicine since they composed 3D networks with high water content flexible rheological features. can self-heal particularly interesting treatment because autonomously their original functionalities repair structural damage. Recently, use self-healing hydrogels as materials has attracted increased interest. In this review, systems used regeneration, especially healing, will be explored. A focus on fabrication methods, characterization tests, mechanism introduced, along applications loaded conventional therapeutic biomaterials. addition, differences between discussed. Graphical
Language: Английский
Citations
3
Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101432 - 101432
Published: Dec. 28, 2024
Flap techniques are indispensable in modern surgery because of their role repairing tissue defects and restoring function. Ischemia-reperfusion oxidative stress-induced injuries the main causes flap failure. Oxidative stress exacerbates cell damage through accumulation reactive oxygen species (ROS), thereby affecting function survival. Effective management these factors is essential for improving survival post-operative recovery. In this study, we utilized hollow mesoporous cerium dioxide nanoparticles loaded with quercetin, which were later into a light-cured double cross-linked hydrogel (HQu@BC) injected site to activate macrophage reprogramming maintain local ROS homeostasis reduce inflammation. Quercetin scavenges reduces mitochondrial due its intrinsic reducing structures such as catechols, carbon-carbon bonds, hydroxyl synergistic nanoparticles, inhibits inflammation by suppressing M1 polarization. This system continuously regulates levels, kills bacteria ultimately inflammation, creating favorable microenvironment innovative injectable composite nanoparticle material has anti-inflammatory, antioxidant, antimicrobial, healing-promoting properties, providing new approach success surgery.
Language: Английский
Citations
3
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 268, P. 131874 - 131874
Published: April 30, 2024
Language: Английский
Citations
2
Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 102(12), P. 1425 - 1450
Published: Oct. 2, 2024
Language: Английский
Citations
1