Nanosonosensitizer Optimization for Enhanced Sonodynamic Disease Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 23, 2024

Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.

Language: Английский

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MOF‐818 Nanozyme Suppresses Calcium Oxalate Kidney Stones by Alleviating Oxidative Stress and Inflammatory Injury

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 22, 2024

Abstract There remains a lack of effective drugs to alleviate the kidney stones caused by oxidative stress and inflammatory damage. The MOF‐818 nanozyme is utilized lessen generation reactive oxygen species (ROS) effectively, restore membrane potential mitochondria, regulate cell cycle, decrease death, hinder recruitment macrophages, mitigate release factors in macrophages. These effects are attributed nanozyme's ability mimic enzyme properties catalase (CAT) superoxide dismutase (SOD). It demonstrated that this can reduce calcium oxalate crystal deposition reducing renal injury high concentration oxalate, upregulate expression levels SOD CAT tissues, downregulate adhesion proteins factor IL‐6 TNF‐α, promote polarization macrophages from M1 M2 phenotype rat model induced ethylene glycol. Overall, has effectively suppress harm hence lowering likelihood stone formation. also expected be used as an alternative drug for treatment provide experimental theoretical basis development new nanomedicines.

Language: Английский

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Copper-based metal–organic frameworks for antitumor application

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 22, 2025

It is urgent to exploit multifunctional materials and combined approaches for efficient antitumor effects. Copper-based metal–organic frameworks (Cu-MOFs) have excellent performances in catalysis, biocompatibility, photothermal conversion, regulate metabolism, which make them attract more attention application. Therefore, this review, representative ligands, synthetic methods, mechanism, applications of Cu-MOFs were provided. Special emphasis placed on the recent drug carriers, therapy, tumor imaging, theranostic, are summarized with examples. Finally, we presented dilemma faced by offered a new perspective future Hopefully, review may serve as reference further development application Cu-MOFs.

Language: Английский

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Kaixuan Qibi granules attenuate myocardial fibrosis through BRD4 blockade regulated by the NF-κB/NLRP3 signaling pathway

Journal of Traditional and Complementary Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Polypyrrole/iron-glycol chitosan nanozymes mediate M1 macrophages to enhance the X-ray-triggered photodynamic therapy for bladder cancer by promoting antitumor immunity

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135608 - 135608

Published: Sept. 1, 2024

Language: Английский

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Ultrasound-responsive heterojunction sonosensitizers for multifunctional synergistic sonodynamic therapy

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110777 - 110777

Published: Dec. 1, 2024

Language: Английский

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