iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111215 - 111215
Published: Oct. 19, 2024
Language: Английский
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(15), P. 17151 - 17192
Published: July 24, 2024
The advancement of precision medicine in modern biomedicine has been significantly propelled by the emergence micro/nanorobots. combination micro/nanorobots and offers unique advantages holds attractive potential for applications. It effectively addresses challenges encountered traditional robots areas such as driving, sensing, intelligence other aspects, especially application cancer cardiovascular diseases, which is a hot field interdisciplinary research recent years. This review succinctly delineates analyzes advancements First, achievements years are systematically classified introduced from four perspectives: manufacturing design, drive control, biomedical degradation. In particular, in-depth discussions were conducted regarding solutions each stage. Second, based on latest results applications, development direction industrial applications key technical aspects that need to be paid attention emphasized. Finally, we discuss opportunities future, it expected will become more sophisticated capable performing multiple medical functions tasks. They implemented vivo assist doctors diagnosing treating diseases. shows significant medicine.
Language: Английский
Citations
11
Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 2, 2025
Abstract Electrospinning is increasingly used as a staple technology for the fabrication of nano‐ and micro‐fibers different materials. Most processes utilize direct current (DC) electrospinning, multitude DC‐electrospinning tools ranging from research to commercial production systems currently available. Yet, there are numerous studies performed on electrospinning techniques utilizing non‐DC, periodic electric fields, or alternating (AC) electrospinning. Those demonstrate strong potential AC‐electrospinning sustainable various nanofibrous materials structures. Although tremendous progress achieved in development over last 10 years, this technique remains uncommon. This paper reviews concepts, instrumentation, technology. The main focus review most studied, “electric wind” driven tentatively named field (AFES). latter term emphasizes role AC field's confinement fiber‐generating electrode absence counter such an system. synopses AFES process parameters, spinneret designs, benefits obstacles, advancements electrospun nano/micro‐fibrous materials/structures their applications given, future directions discussed.
Language: Английский
Citations
1
Advanced Engineering Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 13, 2025
Electrospinning is a versatile technique for producing micro‐ and nanoscale fibers, offering vast potential to address critical market demands, particularly in biomedical engineering. However, the industrial adoption of electrospinning as manufacturing technology faces significant hurdles, notably achieving precise control over fiber properties ensuring reproducibility scalability. These challenges directly impact its viability creating advanced products. Bridging gap between material properties, end‐user requirements, process parameters essential unlocking full electrospinning. This work provides comprehensive review modalities, operational factors, modeling techniques, emphasizing their role optimizing process. The use strategies machine learning methods explored, showcasing enhance performance. highlights connection product performance electrospinning, well necessary conditions applications. In addition, identifies gaps unexplored areas, roadmap future innovation fabrication. By synergy intelligent design applications, this lays groundwork advancements, positioning cornerstone next‐generation technologies.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(5), P. 666 - 666
Published: May 16, 2024
Organ-on-a-chip technology is attracting growing interest across various domains as a crucial platform for drug screening and testing set to play significant role in precision medicine research. Lymph nodes, being intricately structured organs essential the body’s adaptive immune responses antigens foreign particles, are pivotal assessing immunotoxicity of novel pharmaceuticals. Significant progress has been made research on structure function lymphatic system. However, there still an urgent need develop prospective tools techniques delve deeper into its diseases’ pathological physiological processes corresponding immunotherapeutic therapies. Organ chips can accurately reproduce specific functional areas lymph nodes better simulate complex microstructure interactions between different cells, which convenient studying biological processes. This paper reviews existing node their design approaches. It discusses applications above systems modeling cell motility, cell–cell interactions, vaccine responses, testing, cancer Finally, we summarize challenges that current faces terms structure, source, extracellular matrix simulation provide outlook future direction integrated system chips.
Language: Английский
Citations
5
Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24
Published: Feb. 18, 2025
The science of Bone tissue engineering (TE) is quickly progressing. Engineering bone usually applications a synthetic extracellular matrix, cells or osteoblasts that can convert to osteoblasts, and adjusting causes boost adhesion, distinction, mineralized construction cells. Extremely porous scaffolds perform an important character in cell planting, propagation, fresh 3D-tissue construction. Reformative medicine track multi-disciplinary approach for the novel substances' development appliance, various defects therapy. presentation polyhedral oligomeric silsesquioxane (POSS) bio-polymeric scaffold has been shown develop biotic attributes hybrid combinations. This review focuses on influence POSS within Chitosan (CS), Hydroxyapatite (HA), zeolite matrixes, drawing, advantages limitations materials mentioned bone.
Language: Английский
Citations
0
Materials Horizons, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The growing plastic pollution crisis demands novel approaches, with innovative materials that mimic robotic behaviors emerging as a promising solution.
Language: Английский
Citations
0
BMEMat, Journal Year: 2025, Volume and Issue: unknown
Published: March 26, 2025
Abstract Effectively controlling deep non‐compressible bleeding remains a major challenge. In this study, by mimicking nanofiber structure and netting blood cells function of fibrin network in clots, we develop novel bioinspired quaternized chitosan sponge with distinct filtration plasma absorption bifunction for rapid hemostasis. The possesses unique gradient pore small pores on the outer surface large inner part. effectively capture efficiency as high 91.7%, while endow an ultrahigh liquid capacity (93 g/g), surpassing previously reported literature records. demonstrates hemostasis time 2.5 times faster than that commercial gelatin® hemostatic when treating rat liver defect (noncompressible hemorrhage model). When applied to rabbit arterial injury (lethal model), achieves control within only 61.6 s, both collagen® fail stop even after 240 s. This derived from physiological coagulation process may hold great potential pre‐hospital battlefield first aid.
Language: Английский
Citations
0
Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown
Published: April 7, 2025
Abstract Cardiac patches, typically made from non‐conductive polymers, are a promising treatment for myocardial infarction (MI). Introducing electroconductive fibres in these patches improves clinical outcomes, but current production methods limited. This study aims to design and manufacture polymeric cardiac scaffolds that closely match native tissue, using pressurised gyration (PG) conductive polymers (CP). In this study, the first time, polypyrrole (PPy) with polycaprolactone (PCL) chloroform Poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulfonate) (PEDOT:PSS) polyethylene oxide (PEO) water, pressure spun varying CP concentrations (5–10% w/v) applied pressures (0–0.2 MPa). SEM shows resemble thickness uniformity of natural fibres, as PEDOT:PSS 5%, 0 MPa matched endomysium, 10%, aligned perimysium, PPy 7.5%, mimicked epimysium diameters 0.38, 1.02, 3.88 µm, respectively. Four‐point probe testing reveals closest electrical conductivity measurement reported chambers values is 0.22 S m −1 , achieved by 0.2MPa. FTIR verified absence residual solvent, confirming due polymer bonds. The confirms produced have ideal physicochemical properties tissue engineering, demonstrating PG's potential scalable technique manufacturing, advancing patch development MI treatment.
Language: Английский
Citations
0
Journal of Sol-Gel Science and Technology, Journal Year: 2024, Volume and Issue: 111(1), P. 202 - 215
Published: June 11, 2024
Language: Английский
Citations
2
Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101296 - 101296
Published: Oct. 9, 2024
Programmable biomaterials are distinguished by their ability to adjust properties and functions on demand, in a periodic, reversible, or sequential manner. This contrasts with traditional biomaterials, which undergo irreversible, uncontrolled changes. review synthesizes key advances programmable examining design principles, functionalities applications bone regeneration. It charts the transition from emphasizing enhanced precision, safety control, critical clinical biosafety standpoints. We then classify into six types: dynamic nucleic acid-based electrically responsive bioactive scaffolds properties, nanomaterials for targeted regeneration, surface-engineered implants regeneration stimuli-responsive release materials. Each category is analyzed its structural impact tissue engineering. Finally, further concludes highlighting challenges faced suggests integrating artificial intelligence precision medicine enhance application other biomedical fields.
Language: Английский
Citations
2