Cited by Emerging Therapeutic Frontiers in Prostate Health: Novel Molecular Targets and Classical Pathways in comparison with BPH and Prostate Cancer

CDCA genes as prognostic and therapeutic targets in Colon adenocarcinoma DOI

Zongquan Zhao,

Xinwei Feng,

Bo Chen

et al.

Hereditas, Journal Year: 2025, Volume and Issue: 162(1)

Published: Feb. 10, 2025

Abstract Objectives The study investigates the role of Cell Division Cycle Associated (CDCA) genes in colorectal cancer (COAD) by analyzing their differential expression, epigenetic alterations, prognostic significance, and functional associations. Methodology This employed a detailed silico vitro experiments-based methodology. Results RT-qPCR assays reveal significantly elevated mRNA levels CDCA2, CDCA3, CDCA4, CDCA5, CDCA7, CDCA8 COAD cell lines compared to controls. Bisulfite sequencing indicates reduced promoter methylation CDCA gene promoters lines, suggesting an regulatory mechanism. Analysis large TCGA datasets confirms increased expression tissues. Survival analysis using cSurvival database demonstrates negative correlations between patient overall survival. Additionally, Lasso regression-based models predict survival outcomes patients. Investigating immune modulation, inversely correlates with infiltration modulators. miRNA-mRNA network identifies miRNAs targeting genes, validated showing up-regulation has-mir-10a-5p has-mir-20a-5p Drug sensitivity suggests resistance specific drugs patients expression. Furthermore, crucial states COAD, including “angiogenesis, apoptosis, differentiation, hypoxia, inflammation, metastasis.” Additional experiments revealed that CDCA2 CDCA3 knockdown SW480 SW629 cells proliferation colony formation while enhancing migration. Conclusion Overall, elucidates multifaceted progression, providing insights into potential diagnostic, prognostic, therapeutic implications.

Language: Английский

Citations

PolarBytes: Advancing Polar Research with a Centralized Open-Source Data Sharing Platform DOI

Nur Haznirah Hazman,

Rohaizaazira Mohd Zawawi,

Ainin Sofia Jusoh

et al.

Environmental Modelling & Software, Journal Year: 2025, Volume and Issue: unknown, P. 106325 - 106325

Published: Jan. 1, 2025

Language: Английский

Citations

Formulation and development of ACUPA-targeting PEGylated nanoliposomes for treatment of prostate cancer DOI

Seyedeh Alia Moosavian,

M. Amin, Seyedeh Hoda Alavizadeh

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: 95, P. 102830 - 102830

Published: March 4, 2025

Language: Английский

Citations

Developing a Predictive Model for Significant Prostate Cancer Detection in Prostatic Biopsies from Seven Clinical Variables: Is Machine Learning Superior to Logistic Regression? DOI

Juan Moróte, Berta Miró,

Patricia Hernando

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(7), P. 1101 - 1101

Published: March 25, 2025

Objective: This study compares machine learning (ML) and logistic regression (LR) algorithms in developing a predictive model for sPCa using the seven variables from Barcelona (BCN-MRI) model. Method: A cohort of 5005 men suspected having PCa who underwent MRI targeted and/or systematic biopsies was used training, testing, validation. feedforward neural network (FNN)-based SimpleNet (GMV) regression-based (BCN) were developed. The models evaluated discrimination ability, precision-recall, net benefit, clinical utility. Both demonstrated strong performance. Results: GMV achieved an area under curve 0.88 training 0.85 test cohorts (95% CI: 0.83-0.90), while BCN reached 0.84 0.82-0.87), respectively (p > 0.05). exhibited higher recall, making it more suitable scenarios prioritizing sensitivity, whereas precision specificity, optimizing reduction unnecessary biopsies. provided similar benefit over biopsying all men, reducing procedures by 27.5-29% 27-27.5% prostate at 95% Conclusions: Our findings suggest that both ML LR offer high accuracy detection, with exhibiting superior recall specificity. These results highlight need selection based on priorities.

Language: Английский

Citations

Exploring TGF-β signaling in benign prostatic hyperplasia: from cellular senescence to fibrosis and therapeutic implications DOI

Abida Khan,

Hayat Alzahrani, Shatha Ghazi Felemban

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 30, 2025

Language: Английский

Citations

Enhancing the anticancer effects of rosmarinic acid in PC3 and LNCaP prostate cancer cells using titanium oxide and selenium-doped graphene oxide nanoparticles DOI

Maryam Ranjbar, Elham Einafshar, Hossein Javid

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 4, 2025

Prostate cancer remains a significant health concern due to its high mortality rate, emphasizing the need for innovative therapeutic approaches. This study aims explore potential anticancer effects of drug nanocomplex containing rosmarinic acid in treatment prostate cancer, aiming contribute development safer and more effective options patients. Nanocomposite Graphene Oxide was synthesized following Hummers' method. The resulted product dissolved deionized water with prepare final product. To investigate acid@Se-TiO2-GO, PC3, LNCaP, normal (HFF-1) cell lines were treated varying concentrations (7.8, 15.6, 31.2, 62.5, 125, 250, 500 µg/ml) nanocomplex. Cell viability assessed using Resazurin test, while levels reactive oxygen species (ROS), gene expression (Bcl-2 Bax), total antioxidant capacity measured both cancerous cells. Se-TiO2-GO nanoparticles demonstrated entrapment efficiency loading acid. IC50 values after 24 48 h RA significantly greater than those recorded treatments involving acid@Se-TiO2-GO. Treatment acid@Se-TiO2-GO decreased increased apoptosis PC3 LNCaP cells, showing no inhibitory on line at toxic Additionally, dose-dependent increase ROS levels, decrease capacity, elevated Bax expression, reduced Bcl-2 observed cells cytotoxic appear be mediated through generation oxidative stress induction apoptosis. unique formulation these holds promise future strategies.

Language: Английский

Citations

Thiazolidine Derivatives as Promising Prostate Cancer Agents: Design, Synthesis, In Vitro Evaluation, DFT, ADME, POM, Docking, and Toxicity Studies DOI

Hamsa Hussein Al-Hujaj,

Ahmed A. Majed,

Qeaser R. Abdalzahra

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142544 - 142544

Published: April 1, 2025

Language: Английский

Citations

Robotic Ultrasound Scanning End-effector with Adjustable Constant Contact Force DOI

Zehao Wu, Xianli Wang, Yuning Cao

et al.

Cyborg and Bionic Systems, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 1, 2025

In modern medical treatment, ultrasound scanning provides a radiation-free imaging method for the diagnosis of soft tissues via skin contact. However, exerted contact force heavily relies on skill and experience operator, which poses great inspection instability. This article reports robotic system with constant-force end-effector. Its uniqueness is introduction hybrid active-passive control approach to maintaining constant between probe continually changing surface. particular, passive mechanism strong buffering variation. The active improves flexibility long-stroke positioning. Experimental tests both silicone models human volunteers demonstrate capability proposed obtaining qualified images high repeatability. Moreover, ease operation US verified. work promising assist doctors in conducting better cushier imaging.

Language: Английский

Citations

Emerging Therapeutic Frontiers in Prostate Health: Novel Molecular Targets and Classical Pathways in comparison with BPH and Prostate Cancer DOI

Muhammad Sajjad Hassan,

Hafiz Muhammad Irfan,

Alamgeer

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104590 - 104590

Published: Dec. 1, 2024

Language: Английский

Citations