Advances in Oral Solid Drug Delivery Systems: Quality by Design Approach in Development of Controlled Release Tablets DOI Creative Commons

Prachi Atre,

Syed A. A. Rizvi

BioChem, Journal Year: 2025, Volume and Issue: 5(2), P. 9 - 9

Published: April 25, 2025

Oral solid drug delivery continues to be the gold standard in pharmaceutical formulations, owing its cost-effectiveness, ease of administration, and high patient compliance. Tablets, most widely used dosage form, are favored for their precise dosing, simplicity, economic advantages. Among these, controlled release (CR) tablets stand out ability maintain consistent levels, enhance therapeutic efficacy, reduce dosing frequency, thereby improving adherence treatment outcomes. A well-designed CR system ensures a sustained targeted supply, optimizing performance while minimizing side effects. This review delves into latest advancements with particular focus on hydrophilic matrix systems, which regulate through mechanisms such as swelling, diffusion, erosion. These systems rely variety polymers drug-retarding agents achieve tailored profiles. Recent breakthroughs crystal engineering polymer science have further enhanced solubility bioavailability, addressing critical challenges associated poorly soluble drugs. In terms manufacturing, direct compression has emerged efficient method producing tablets, streamlining production ensuring release. The integration Quality by Design framework been instrumental product systematically linking formulation process variables patient-centric quality attributes. advent cutting-edge technologies artificial intelligence 3D printing is revolutionizing field formulations. AI enables predictive modeling data-driven optimization profiles, facilitates development personalized medicines highly customizable kinetics. innovations paving way more patient-specific therapies. However, regulatory hurdles, patent constraints, need robust vivo validation remain significant barriers widespread adoption these advanced technologies. succinct underscores synergistic traditional emerging strategies tablets. It highlights potential co-crystal particularly those produced via compression, improve adherence, deliver superior By bridging gap between established practices innovative approaches, this poised address unmet clinical needs advance future oral delivery.

Language: Английский

Revolutionizing Prostate Cancer Therapy: Artificial intelligence – based Nanocarriers for Precision Diagnosis and Treatment DOI
Moein Shirzad,

Afsaneh Salahvarzi,

Sobia Razzaq

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104653 - 104653

Published: Feb. 1, 2025

Language: Английский

Citations

3
Natural drug delivery systems for the treatment of neurodegenerative diseases DOI
Greta Kaspute, Arūnas Ramanavičius,

Urtė Prentice

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Feb. 10, 2025

Language: Английский

Citations

1
Engineering Polymers: From Biodegradable Platforms to Intelligent Drug Carriers DOI

Jasleen Kaur Minhas,

V. D. Aher, Sushmitha Bujji

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: April 4, 2025

Language: Английский

Citations

0
Advances in Oral Solid Drug Delivery Systems: Quality by Design Approach in Development of Controlled Release Tablets DOI Creative Commons

Prachi Atre,

Syed A. A. Rizvi

BioChem, Journal Year: 2025, Volume and Issue: 5(2), P. 9 - 9

Published: April 25, 2025

Oral solid drug delivery continues to be the gold standard in pharmaceutical formulations, owing its cost-effectiveness, ease of administration, and high patient compliance. Tablets, most widely used dosage form, are favored for their precise dosing, simplicity, economic advantages. Among these, controlled release (CR) tablets stand out ability maintain consistent levels, enhance therapeutic efficacy, reduce dosing frequency, thereby improving adherence treatment outcomes. A well-designed CR system ensures a sustained targeted supply, optimizing performance while minimizing side effects. This review delves into latest advancements with particular focus on hydrophilic matrix systems, which regulate through mechanisms such as swelling, diffusion, erosion. These systems rely variety polymers drug-retarding agents achieve tailored profiles. Recent breakthroughs crystal engineering polymer science have further enhanced solubility bioavailability, addressing critical challenges associated poorly soluble drugs. In terms manufacturing, direct compression has emerged efficient method producing tablets, streamlining production ensuring release. The integration Quality by Design framework been instrumental product systematically linking formulation process variables patient-centric quality attributes. advent cutting-edge technologies artificial intelligence 3D printing is revolutionizing field formulations. AI enables predictive modeling data-driven optimization profiles, facilitates development personalized medicines highly customizable kinetics. innovations paving way more patient-specific therapies. However, regulatory hurdles, patent constraints, need robust vivo validation remain significant barriers widespread adoption these advanced technologies. succinct underscores synergistic traditional emerging strategies tablets. It highlights potential co-crystal particularly those produced via compression, improve adherence, deliver superior By bridging gap between established practices innovative approaches, this poised address unmet clinical needs advance future oral delivery.

Language: Английский

Citations

0