Hyperbaric Oxygen Boosts Antitumor Efficacy of Copper-Diethyldithiocarbamate Nanoparticles against Pancreatic Ductal Adenocarcinoma by Regulating Cancer Stem Cell Metabolism

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Cuproptosis-based cancer nanomedicine has received widespread attention recently. However, cuproptosis against pancreatic ductal adenocarcinoma (PDAC) is severely limited by stem cells (CSCs), which reside in the hypoxic stroma and adopt glycolysis metabolism accordingly to resist cuproptosis-induced mitochondria damage. Here, we leverage hyperbaric oxygen (HBO) regulate CSC overcoming tumor hypoxia augment elimination efficacy of polydopamine hydroxyethyl starch stabilized copper-diethyldithiocarbamate nanoparticles (CuET@PH NPs). Mechanistically, while HBO CuET@PH NPs inhibit oxidative phosphorylation, respectively, combination potently suppresses energy CSCs, thereby achieving robust inhibition PDAC elongating mice survival importantly. This study reveals novel insights into effects on suggests that with holds significant clinical translation potential for patients.

Language: Английский

---

Glutaminolysis inhibition boosts photodynamic therapy to eliminate cancer stem cells

Biomaterials, Journal Year: 2024, Volume and Issue: 306, P. 122497 - 122497

Published: Feb. 2, 2024

Language: Английский

---

pH/GSH dual-responsive nanoparticle for auto-amplified tumor therapy of breast cancer

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 10, 2024

Language: Английский

---

Photodynamic therapy with NIR-II probes: review on state-of-the-art tools and strategies

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(23), P. 5815 - 5842

Published: Jan. 1, 2024

The current state-of-the art on NIR-II-activated photosensitizers and their applications for the deep tumor treatment, as well recent efforts that combine NIR-II activated PDT with other complementary therapeutic routes.

Language: Английский

---

Engineering tumor-oxygenated nanomaterials: advancing photodynamic therapy for cancer treatment

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: March 13, 2024

Photodynamic therapy (PDT), a promising treatment modality, employs photosensitizers to generate cytotoxic reactive oxygen species (ROS) within localized tumor regions. This technique involves administering photosensitizer followed by light activation in the presence of (O 2 ), resulting ROS production. PDT’s spatiotemporal selectivity, minimally invasive nature, and compatibility with other modalities make it compelling therapeutic approach. However, hypoxic microenvironment (TME) poses significant challenge conventional PDT. To overcome this hurdle, various strategies have been devised, including in-situ O generation, targeted delivery, vasculature normalization, modulation mitochondrial respiration, photocatalytic generation. review aims provide comprehensive overview recent developments designing tumor-oxygenated nanomaterials enhance PDT efficacy. Furthermore, we delineate ongoing challenges propose improve clinical impact cancer treatment.

Language: Английский

---

CD133 significance in glioblastoma development: in silico and in vitro study

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: March 6, 2024

Abstract Background Glioblastoma multiform (GBM) is among the commonly diagnosed brain malignancies with poor prognosis. CD133 has been introduced as an oncogene in various cancers, like GBM. This study aimed to investigate significance of GBM development using silico and vitro techniques. Method The TCGA-GBM database was analyzed for correlational comparative studies. After selecting U87MG cell line, CD133-siRNA transfected into cells treated temozolomide. viability, cycle, migration, clonogenicity, apoptosis groups were investigated MTT, flow cytometry, wound-healing, colony formation, annexin V/PI assays. Using qRT-PCR method, mRNA expression levels MMP16 , SOX2 RAF1 MAP2K1 MAPK3 PIK3CA AKT3 mTOR CDK4 BCL2 studied. Results silencing improves rate, arrests cycle at sub-G1 phase, suppresses clonogenicity cells, inhibits PI3K/Akt MAPK pathways via downregulating expression. Besides, combining temozolomide treatment considerably migration compared monotherapy. Conclusion can regulate modulate apoptosis, Combining increases sub-G1, Graphical

Language: Английский

---

Rhodium–Rhenium Alloy Nanozymes for Non-inflammatory Photothermal Therapy

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 21653 - 21664

Published: April 22, 2024

Analogous to thermal ablation techniques in clinical settings, cell necrosis induced during tumor photothermal therapy (PTT) can provoke an inflammatory response that is detrimental the treatment of tumors. In this study, we employed a straightforward one-step liquid-phase reduction process synthesize uniform RhRe nanozymes with average hydrodynamic size 41.7 nm for non-inflammatory therapy. The obtained showed efficient near-infrared (NIR) light absorption effective PTT, coupled remarkable capability scavenge reactive oxygen species (ROS) anti-inflammatory treatment. After laser irradiation, 4T1 tumors were effectively ablated without obvious recurrence within 14 days, along no increase pro-inflammatory cytokine levels. Notably, these demonstrated high biocompatibility normal cells and tissues, both

Language: Английский

---

Glutathione‐Sensitive Photosensitizer–Drug Conjugates Target the Mitochondria to Overcome Multi‐Drug Resistance in Cancer

Advanced Science, Journal Year: 2024, Volume and Issue: 11(30)

Published: June 19, 2024

Abstract Multi‐drug resistance (MDR) is a major cause of cancer therapy failure. Photodynamic (PDT) promising modality that can circumvent MDR and synergize with chemotherapies, based on the generation reactive oxygen species (ROS) by photosensitizers. However, overproduction glutathione (GSH) cells scavenges ROS restricts efficacy PDT. Additionally, side effects normal tissues are unavoidable after PDT treatment. Here, to develop organic systems deliver effective anticancer chemotherapy simultaneously very little effects, three GSH‐sensitive photosensitizer‐drug conjugates (CyR‐SS‐L) designed synthesized. CyR‐SS‐L localized in mitochondria then cleaved into CyR‐SG SG‐L parts reacting consuming high levels intracellular GSH. Notably, generates tumor instead be exploited for part used chemotherapy. inhibits better inhibitory activity than indocyanine green, photosensitizer (PS) clinical applications. The results appear first show may as an alternative agent more against cancers without obvious damaging combination PDT, GSH depletion,

Language: Английский

---

Engineered Cell Membrane Coating Technologies for Biomedical Applications: From Nanoscale to Macroscale

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Cell membrane coating has emerged as a promising strategy for the surface modification of biomaterials with biological membranes, serving cloak that can carry more functions. The cloaked inherit diverse intrinsic biofunctions derived from different cell sources, including enhanced biocompatibility, immunity evasion, specific targeting capacity, and immune regulation regenerative microenvironment. characteristics biomimicry biointerfacing have demonstrated versatility technology on variety biomaterials, thus, furthering research into wide range biomedical applications clinical translation. Here, preparation coatings is emphasized, sizes coated nanoscale to macroscale well engineering strategies introduce additional are summarized. Subsequently, utilization biomimetic membrane-cloaked in discussed, drug delivery, imaging phototherapy, cancer immunotherapy, anti-infection detoxification, implant modification. In conclusion, latest advancements preclinical studies, along multiple benefits membrane-coated nanoparticles (NPs) systems, elucidated.

Language: Английский

---

Breaking the Resistance: Photodynamic Therapy in Cancer Stem Cell-Driven Tumorigenesis

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 559 - 559

Published: April 24, 2025

Cancer stem cells (CSCs) are essential for the growth of malignancies because they encourage resistance to cancer therapy and make metastasis relapse easier. To effectively tackle obstacles presented by CSCs, novel therapeutic approaches required. Photodynamic (PDT) is a promising treatment option cells, which uses light-sensitive medications that activated light wavelengths. This review investigates use PDT overcome driven CSCs have innate mechanisms. works causing tumor accumulate photosensitizers (PSs) selectively. The reactive oxygen species (ROS), kill released these PSs when stimulated light. According recent developments in PDT, its efficacy may go beyond traditional providing viable remedy shown CSCs. Researchers want improve targeted elimination selective targeting combining with new customized delivery systems. Studies emphasize how affects as well bulk cells. studies, not only limits CSC but also modifies their microenvironment, lowers possibility recovery. Additionally, studies being conducted on utilization immunotherapeutic techniques inherent In conclusion, strategy treating carcinogenesis By applying most advancements technologies recognizing it interacts this has potential surpass mechanisms future patients. Clinical preclinical highlight CSC-targeted current limitations. Future efforts should focus clinical validation, optimizing PS use, developing effective combination strategies target

Language: Английский

---