Therapeutic Controlled Release Strategies for Human Osteoarthritis

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract Osteoarthritis is a progressive, irreversible debilitating whole joint disease that affects millions of people worldwide. Despite the availability various options (non‐pharmacological and pharmacological treatments therapy, orthobiologics, surgical interventions), none them can definitively cure osteoarthritis in patients. Strategies based on controlled release therapeutic compounds via biocompatible materials may provide powerful tools to enhance spatiotemporal delivery, expression, activities candidate agents as means durably manage pathological progression affected joints upon convenient intra‐articular (injectable) delivery while reducing their clearance, dissemination, or side effects. The goal this review describe current knowledge advancements treat osteoarthritis, from basic principles applications vivo using recombinant molecules drugs more innovatively gene sequences, providing degree confidence patients close future.

Language: Английский

Localized Hydrogel Microspheres for Osteoarthritis Treatment: Recruitment and Differentiation of Stem Cells

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Osteoarthritis (OA) represents a common degenerative joint disorder marked by progressive cartilage degradation, necessitating innovative therapeutic approaches beyond symptom management. Here, this study introduces novel strategy leveraging the regenerative capabilities of mesenchymal stem cells (MSCs) utilizing bioactive extracellular matrix (ECM) derived from IFN-γ-stimulated MSCs, encapsulated within aldehyde- and methacrylic anhydride-modified hyaluronic acid hydrogel microspheres (AH). This engineered scaffold effectively mimics native microenvironment, promoting targeted adhesion retention at damaged sites via spontaneous Schiff base reactions. Notably, IFN-γ-ECM@AH facilitate localized release key chemokines, such as CXCL12, enhancing endogenous cell recruitment, factors (e.g., TGF-βI TGF-β3) to drive chondrogenic differentiation. Additionally, possesses binding for cellular integrins, further augmenting potential cells. Collectively, approach presents dual-action mechanism that supports efficient repair regeneration, positioning microenvironment promising avenue OA potentially other conditions.

Language: Английский

Lesion-localized hydrogels functionalized with engineered extracellular matrix restore cellular homeostasis by enhancing mitochondrial energy metabolism for osteoarthritis therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 155662 - 155662

Published: Sept. 13, 2024

Language: Английский