Nanomaterials evoke pyroptosis boosting cancer immunotherapy DOI Creative Commons
Zhenhua Li,

Ziyue Xi,

Chuanyong Fan

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 852 - 875

Published: Nov. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Language: Английский

Precision Pore Structure Optimization of Additive Manufacturing Porous Tantalum Scaffolds for Bone Regeneration : A proof-of-concept study DOI
Jiale Jin, Dongyu Wang, Hu Qian

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 313, P. 122756 - 122756

Published: Aug. 15, 2024

Language: Английский

Citations

9
Single-cell technology for cell-based drug delivery and pharmaceutical research DOI

Huihui Hu,

Yunlong Fan, Jiawen Wang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113587 - 113587

Published: March 1, 2025

Language: Английский

Citations

0
Imaging‐Guided Microscale Photothermal Stereolithography Bioprinting DOI Creative Commons
Jingyu Sun,

Tianqi Fang,

Yuze Zhang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Stereolithography bioprinting relies heavily on costly photoinitiators for polymerization, limiting its potential further technical advancement to meet growing needs in tissue engineering and regenerative medicine. Thermal initiators, contrast, are low cost, rapid growth of the photothermal conversion field offers a wide range materials tools convert light into heat. However, high-resolution stereolithography remains unattainable due difficulty confining heat an aqueous environment. Here, this challenge has been fully addressed by establishing imaging-guided microscale (ImPSB). This technique is achieved through building novel system that provides depth-resolved visualization printing dynamics, creating unique initiator second near-infrared window, developing new bioink seeing controlling gelation process. ImPSB achieves resolution ≈47 µm generates smooth lines arbitrarily designed shapes with cross-sectional diameter as small ≈104 µm, representing unprecedented scale from stereolithography. Its cellular biocompatibility both bioscaffold cell-laden hydrogel demonstrated, feasibility transdermal also shown. work sets path where vast resources can be utilized.

Language: Английский

Citations

0
Preserving the Immune‐Privileged Niche of the Nucleus Pulposus: Safeguarding Intervertebral Discs from Degeneration after Discectomy with Synthetic Mucin Hydrogel Injection DOI Creative Commons
Huan Wang, Song Chen, Zhao Liu

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(43)

Published: Aug. 29, 2024

Abstract Intervertebral disc (IVD) herniation is a prevalent spinal disorder, often necessitating surgical intervention such as microdiscectomy for symptomatic relief and nerve decompression. IVDs comprise gel‐like nucleus pulposus (NP) encased by an annulus fibrosus (AF), their avascular nature renders them immune‐privileged. Microdiscectomy exposes the residual NP to immune system, precipitating cell infiltration attack that exacerbates IVD degeneration. While many efforts in tissue engineering field are directed toward regeneration, inherently limited regenerative capacity due low‐cellularity of challenging mechanical environment spine impedes success. This study, aiming prevent degeneration post‐microdiscectomy, utilizes mucin‐derived gels (Muc‐gels) form gel at site, inspired natural mucin coating on living organisms evade reorganization. It shown type I macrophages present severely degenerated human discs. Encapsulating within Muc‐gels prevents fibrous encapsulation macrophage mouse subcutaneous model. The injection rat tail model up 24 weeks post‐operation. Mechanistic investigations indicate attenuate into NPs, offering durable protection against post‐microdiscectomy.

Language: Английский

Citations

1
The anti-oxidation related bioactive materials for intervertebral disc degeneration regeneration and repair DOI

Yingjie Mai,

Siying Wu, Penghui Zhang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 19 - 40

Published: Nov. 9, 2024

Language: Английский

Citations

1
Nanomaterials evoke pyroptosis boosting cancer immunotherapy DOI Creative Commons
Zhenhua Li,

Ziyue Xi,

Chuanyong Fan

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 852 - 875

Published: Nov. 23, 2024

Cancer immunotherapy is currently a very promising therapeutic strategy for treating tumors. However, its effectiveness restricted by insufficient antigenicity and an immunosuppressive tumor microenvironment (ITME). Pyroptosis, unique form of programmed cell death (PCD), causes cells to swell rupture, releasing pro-inflammatory factors that can enhance immunogenicity remodel the ITME. Nanomaterials, with their distinct advantages different techniques, are increasingly popular, nanomaterial-based delivery systems demonstrate significant potential potentiate, enable, augment pyroptosis. This review summarizes discusses emerging field nanomaterials-induced pyroptosis, focusing on mechanisms pyroptosis pathways strategies activate or specific Additionally, we provide perspectives development this field, aiming accelerate further clinical transition.

Language: Английский

Citations

0