AlphaFold 3.0 Prediction Reveals Stronger Interaction between Oleic Acid and Colipase than Palmitic Acid DOI
Liyou Zheng, Xiaoting Zhou, Zhan Ye

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

The interaction between colipase and lipase is known to be crucial for lipid digestion, but the roles of other factors remain unclear. This study explores dynamics pancreatic hydrolysis facilitated by colipase, with a focus on regulatory fatty acids calcium ions. Using computational modeling, including insights from AlphaFold 3.0, we elucidate structural interactions essential activity. prediction highlights significant role ions in altering lipase–colipase complex, thereby changing catalytic efficiency. We further demonstrate that slower rates are associated stronger binding affinity oleic acid, as well occupation pocket acid presence predictions provide robust framework experimental validation potential applications. These findings offer deeper into dietary digestion highlight avenues interventions addressing malnutrition.

Language: Английский

NMR spectroscopy combined with chemometrics for quality assessment of common vegetable oils: A review DOI
Tao Shi,

Tenghui Dai,

Tao Zhang

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104889 - 104889

Published: Jan. 1, 2025

Language: Английский

Citations

1
Food inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food? DOI Creative Commons

Zhangtie Wang,

Changzheng Yuan,

Yansong Zhang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Food is a critical factor of chronic inflammation. Few studies tried to quantize inflammatory effects food. Moreover, the discrepancies in among foods within same food group are frequently ignored.

Language: Английский

Citations

4
Microwave‐assisted synthesis of 4,4‐dimethylsterol‐conjugated linoleic acid ester and its lipid‐lowering benefits evaluation DOI
Y. M. Xing, Yiwen Guo,

Dekun Cheng

et al.

Journal of Food Science, Journal Year: 2025, Volume and Issue: 90(4)

Published: April 1, 2025

Abstract 4,4‐Dimethylsterol (RST), rich in rice bran oil, is often considered to have good lipid‐lowering properties, and conjugated linoleic acid (CLA), a special fatty acid, also similar but the low solubility poor oxidation stability limits their application food industry. Typically, sterol esters better after esterification. However, it difficult esterify 4,4‐dimethylsterol for its additional methyl groups. Therefore, microwave‐assisted esterification of with CLA was developed this study, function 4,4‐dimethylsterol–CLA (RSE) evaluated high‐fat diet (HFD)‐induced mice model. The results showed that when reaction condition molar ratio RST 1:3 catalyzed 5% (mol%) p‐toluene sulfonic 25% dodecyl benzene maintained at microwave reactor 125 min 100°C, highest rate 93.63% acquired. Furthermore, HFD‐induced experiments demonstrated RSE could significantly reduce body weight, as well serum liver triglyceride (TG) levels, while exert hepatoprotective properties compared RST. Additionally, found affect appetite regulate expression lipid metabolism–related genes mice. These findings suggest holds potential field functional foods.

Language: Английский

Citations

0
4,4-Dimethylsterols Regulate Hepatic Lipophagy via AMPK Pathway: A Novel Perspective on the Lipid-Lowering Effects of Phytosterols DOI

Y. Z. Qian,

Yiwen Guo, Zhu Zhu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105983 - 105983

Published: Jan. 1, 2025

Language: Английский

Citations

0
Plant-based whipping cream: A promising sustainable alternative to dairy products DOI

Hua Xu,

Mingcui Huang,

Huilin Huan

et al.

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 103494 - 103494

Published: March 1, 2025

Language: Английский

Citations

0
Structural changes of potato starch and activity inhibition of starch digestive enzymes by anthocyanin from lingonberry (Vaccinium uliginosum L.) retarded starch digestibility DOI
Heng Zhou,

Shi-ming Peng,

Yongmin Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136673 - 136673

Published: Oct. 18, 2024

Language: Английский

Citations

2
AlphaFold 3.0 Prediction Reveals Stronger Interaction between Oleic Acid and Colipase than Palmitic Acid DOI
Liyou Zheng, Xiaoting Zhou, Zhan Ye

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

The interaction between colipase and lipase is known to be crucial for lipid digestion, but the roles of other factors remain unclear. This study explores dynamics pancreatic hydrolysis facilitated by colipase, with a focus on regulatory fatty acids calcium ions. Using computational modeling, including insights from AlphaFold 3.0, we elucidate structural interactions essential activity. prediction highlights significant role ions in altering lipase–colipase complex, thereby changing catalytic efficiency. We further demonstrate that slower rates are associated stronger binding affinity oleic acid, as well occupation pocket acid presence predictions provide robust framework experimental validation potential applications. These findings offer deeper into dietary digestion highlight avenues interventions addressing malnutrition.

Language: Английский

Citations

0