Circulating Interleukin-6 Mediates PM2.5-induced Ovarian Injury by Suppressing the PPARγ Pathway

Research, Journal Year: 2024, Volume and Issue: 7

Published: Jan. 1, 2024

Exposure to airborne fine particulate matter (PM 2.5 ) is strongly associated with poor fertility and ovarian damage. However, the mechanism underlying this remains largely unclear. Here, we found that PM markedly impaired murine reserve, decreased hormone levels, aggravated inflammation. Circulating interleukin-6 (IL-6) was elevated in -exposed mice further confirmed mediate damage by IL-6 recombinant protein intervention. exposure led increased alveolar macrophage infiltration lungs. clearance clodronate liposomes could not fully reverse levels injury, suggesting macrophages were probably only source of circulating IL-6. Further experiments indicated mainly targeted theca–interstitial cells testosterone synthesis via suppressing peroxisome proliferator-activated receptor γ (PPARγ) pathway. In addition, apoptosis granulosa restriction follicular growth observed co-cultures IL-6-treated cells, which be reversed PPARγ agonist. Moreover, IL-6-neutralizing antibodies ameliorated -induced Notably, premature aging patients inversely their function. summary, our findings offer a mechanistic explanation for dysfunction verify as biomarker potential therapeutic target.

Language: Английский

The microbiome’s influence on obesity: mechanisms and therapeutic potential

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский