Graphene-Based Nanocomposites against Hepatocellular Carcinoma via Chemo/Photothermal/Photodynamic Synergistic Therapy DOI
Guohua Yang, Qiaowen Wang, Guolong Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(24), P. 28541 - 28552

Published: Dec. 10, 2024

Single chemotherapy (CT) has difficulty meeting the clinical needs of patients with intermediate and advanced hepatocellular carcinoma (HCC). To solve this problem, graphene-based nanocomposites (DOX/IR820@GNPs) were prepared used to combat HCC through combined photothermal therapy (PTT), photodynamic (PDT), CT by using membrane-penetrating peptide (tLyp-1) hyaluronic acid as tumor-targeting materials IR820@GQDs doxorubicin hydrochloride (DOX) photosensitizer chemotherapeutic drug. The well dispersed in water particle size 98–145 nm zeta −6.0 ∼ −12.8 mV have absorption UV, visible, near-infrared (NIR) regions. Therefore, DOX/IR820@GNPs not only capability fluorescence imaging but also produce reactive oxygen species effects under NIR irradiation. In addition, are biocompatible, can be internalized into HepG2 cells enriched at tumor site dual targeting, accelerate release DOX microacid environment. Importantly, due above properties, PTT PDT kill tumors directly Meanwhile, effect is enhanced high-temperature environments. Finally, optimal anti-HCC was achieved synergistic sensitization PTT/PDT CT.

Language: Английский

Graphene-Based Nanocomposites against Hepatocellular Carcinoma via Chemo/Photothermal/Photodynamic Synergistic Therapy DOI
Guohua Yang, Qiaowen Wang, Guolong Zhang

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(24), P. 28541 - 28552

Published: Dec. 10, 2024

Single chemotherapy (CT) has difficulty meeting the clinical needs of patients with intermediate and advanced hepatocellular carcinoma (HCC). To solve this problem, graphene-based nanocomposites (DOX/IR820@GNPs) were prepared used to combat HCC through combined photothermal therapy (PTT), photodynamic (PDT), CT by using membrane-penetrating peptide (tLyp-1) hyaluronic acid as tumor-targeting materials IR820@GQDs doxorubicin hydrochloride (DOX) photosensitizer chemotherapeutic drug. The well dispersed in water particle size 98–145 nm zeta −6.0 ∼ −12.8 mV have absorption UV, visible, near-infrared (NIR) regions. Therefore, DOX/IR820@GNPs not only capability fluorescence imaging but also produce reactive oxygen species effects under NIR irradiation. In addition, are biocompatible, can be internalized into HepG2 cells enriched at tumor site dual targeting, accelerate release DOX microacid environment. Importantly, due above properties, PTT PDT kill tumors directly Meanwhile, effect is enhanced high-temperature environments. Finally, optimal anti-HCC was achieved synergistic sensitization PTT/PDT CT.

Language: Английский

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