A Constant Filgotinib Delivery Adhesive Platform Based on Polyethylene Glycol (PEG) Hydrogel for Accelerating Wound Healing via Restoring Macrophage Mitochondrial Homeostasis

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Skin wound healing is often hindered by disrupted mitochondrial homeostasis and imbalanced macrophage glucose metabolism, posing a critical challenge to improve patient outcomes. Developing new dressings capable of effectively regulating immune‐metabolic functions remains pressing issue. Herein, highly adhesive polyethylene glycol (PEG) hydrogel loaded with the Janus kinase 1 (JAK1) inhibitor Filgotinib (Fil@GEL) prepared modulate metabolic reprogramming restore normal function. Fil@GEL exhibits superior shear adhesion strength compared commercially available tissue binder products, providing adequate for skin closure. Additionally, capacity inhibit M1‐type polarization suppressing JAK‐STAT signaling pathway, induces shift in macrophages from aerobic glycolysis oxidative phosphorylation, which results decreased lactate production, reduced reactive oxygen species (ROS) levels, restoration homeostasis. The significantly accelerates control group, reduces intra‐wound inflammation, promotes collagen regeneration. In summary, this demonstrates exceptional performance as drug carrier, exerting immunometabolic modulation through firm sustained filgotinib release, underscoring its substantial potential an effective dressing.

Language: Английский

Ultra-small quercetin-based nanotherapeutics ameliorate acute liver failure by combatting inflammation/cellular senescence cycle

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 1035 - 1056

Published: Dec. 11, 2024

Language: Английский