Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus DOI Creative Commons
Irina Vasilieva, Maria Vasilieva, Ilie Vasiliev

et al.

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2024, Volume and Issue: 2(4)

Published: May 22, 2024

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores role Acute Vascular Distress Syndrome (AVDS) in development MIS both adults (MIS-A) and children (MIS-C), providing a comprehensive overview modern research treatment approaches for severe coronavirus infections. Methods Materials: synthesizes findings from multiple studies clinical reports analyze mechanisms SARS-CoV-2 induces AVDS subsequently MIS. Key materials molecular cellular data, case studies, protocols. Diagnostic tools such as PCR serological testing, well various biomarkers like neurofilament light chain galectin-3, are discussed elucidate their roles identifying managing cases. Results: interaction between host endothelial cells, mediated ACE2 receptors, triggers cascade responses leading AVDS. is characterized dysfunction, cytokine storms, mitochondrial distress, collectively contribute pathogenesis Clinical evidence indicates that critical factor severity COVID-19, with widespread implications organ systems, including central peripheral nervous systems. Conclusion: Understanding offers valuable insights into pathophysiology COVID-19. Effective management requires multifaceted approach, combining antiviral therapies, immunomodulators, supportive treatments extracorporeal membrane oxygenation (ECMO). Future should focus on targeted therapies mitigate damage improve patient outcomes

Language: Английский

Role Of Acute Vascular Distress Syndrome In The Development Of Multisystem Inflammatory Syndrome In Sars-Cov-2 And Modern Views On The Research And Treatment Of Critical Coronavirus DOI Creative Commons
Irina Vasilieva, Maria Vasilieva, Ilie Vasiliev

et al.

Special journal of the Medical Academy and other Life Sciences, Journal Year: 2024, Volume and Issue: 2(4)

Published: May 22, 2024

Background: The COVID-19 pandemic, caused by SARS-CoV-2, has highlighted the complex pathology of virus, which extends beyond respiratory symptoms to include multisystem inflammatory syndrome (MIS). This review explores role Acute Vascular Distress Syndrome (AVDS) in development MIS both adults (MIS-A) and children (MIS-C), providing a comprehensive overview modern research treatment approaches for severe coronavirus infections. Methods Materials: synthesizes findings from multiple studies clinical reports analyze mechanisms SARS-CoV-2 induces AVDS subsequently MIS. Key materials molecular cellular data, case studies, protocols. Diagnostic tools such as PCR serological testing, well various biomarkers like neurofilament light chain galectin-3, are discussed elucidate their roles identifying managing cases. Results: interaction between host endothelial cells, mediated ACE2 receptors, triggers cascade responses leading AVDS. is characterized dysfunction, cytokine storms, mitochondrial distress, collectively contribute pathogenesis Clinical evidence indicates that critical factor severity COVID-19, with widespread implications organ systems, including central peripheral nervous systems. Conclusion: Understanding offers valuable insights into pathophysiology COVID-19. Effective management requires multifaceted approach, combining antiviral therapies, immunomodulators, supportive treatments extracorporeal membrane oxygenation (ECMO). Future should focus on targeted therapies mitigate damage improve patient outcomes

Language: Английский

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