Phytochemical analysis, bioactivity, and molecular docking studies of Myrtus communis L. seeds and fruit peel extracts demonstrating antioxidant and anti-tyrosinase properties

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 15, 2025

Myrtus communis L, is an edible medicinal plant with fruit berries used to manufacture liquors, aromatise wine, and sweet foods, beside several folk-medicinal uses. The also endemic Libya, holds promise for its properties, including anti-inflammatory, antioxidant, wound healing, appetising effects. This work aims explore the phytoconstituents present in seeds peels of L by GC-MS LC-ESI-MS analysis, respectively. demonstrated vitro silico antioxidant anti-tyrosinase activities extracts. analysis indicated presence 11 fatty acids myrtle representing 78.61% total seeds' acid contents, where unsaturated linolenic (C18:3) was major (23.11%). Moreover, seven anthocyanins were identified relative percentage 59.84% related peaks area positive ion mode chromatogram. Among compounds, petunidin 3-O-glucoside Malvidin 3-O-rutinoside most abundant at 12.48% and11.87%, Antioxidant assay showed that ethanolic extract exhibited higher DPPH-free radical scavenging compared chloroform (6.89 ± 0.12 2.65 0.03, respectively). Similarly, induced ferric reducing power (FRAP) (4.87 1.02 2.10 0.9, greatest inhibitory effect against tyrosinase enzyme IC50 126.35 0.92 activity 135.27 1.23. tested extracts displayed lower level inhibition standard arbutin (IC50 76.9 0.0). results molecular docking simulations suggest anthocyanins, particularly Cyanidin-3-O-rutinoside, exhibit significant binding affinity could potentially serve as effective natural inhibitors. These compounds may interfere enzyme's catalytic interacting key residues active site.

Language: Английский

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A phytotherapeutic approach to hinder the resistance against clindamycin by MRSA: in vitro and in silico studies

Future Science OA, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 2, 2025

Aims This study investigates the potential effects of essential oils (EOs) in enhancing efficacy clindamycin against Methicillin-resistant Staphylococcus aureus (MRSA) using vitro and computer simulations. The research seeks to identify that exhibit synergistic activity with determine their key active components.

Language: Английский

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Design and synthesis of novel substituted s‐triazines tethered benzenesulfonamides as potential antimicrobial candidates: Antibiofilm and bacterial protein permeability assessments

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract New s ‐triazine hydrazone hybrids ( 4a – 4r ) were designed and synthesized as promising microbial DNA gyrase inhibitors. This was done by taking the lead inhibitor (AstraZeneca arylaminotriazine) a reference. The novel samples subsequently tested antimicrobial agents against certain pathogenic bacteria unicellular fungi. antibiofilm potential membrane leakage test used to determine mechanism of response. minimum inhibitory concentration (MIC) values 4g , 4i between 62.5 250.0 µg/mL. MIC for candidate Staphylococcus aureus, Candida albicans, Enterobacter agglomerans Klebsiella pneumonia are 62.5, 125.0, µg/mL, respectively. Conversely, compound µg/mL C. albicans E. 125.0 S. aureus K. . Besides, molecular docking study performed validate both binding affinity mode newly analogs candidates toward bacterial receptors. nanocomposites had potentials, which encouraging their use in biomedical applications. Consequently, afforded compounds can be employed future optimization.

Language: Английский

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Production of sustainable adsorbent of crosslinked chitosan-oxalate and modified mango (Mangifera indica L.) seed for highly efficient adsorption of crystal violet dye: Water treatment and biomass valorization

Biomass and Bioenergy, Journal Year: 2025, Volume and Issue: 199, P. 107889 - 107889

Published: April 19, 2025

Language: Английский

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Green vegetable waste composited with chitosan as a bioadsorbent for effective removal of methylene blue dye from water: Insight into physicochemical and adsorption characteristics

Biomass and Bioenergy, Journal Year: 2024, Volume and Issue: 193, P. 107528 - 107528

Published: Dec. 5, 2024

Language: Английский

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Novel biocomposite of ionic cross-linked chitosan and acid-treated potato (Solanum tuberosum L.) peel agro-waste for highly efficient removal of methylene blue dye from water

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138742 - 138742

Published: Dec. 15, 2024

Language: Английский

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Tackling Biofilm Resistance of Gram-Positive and Gram-Negative Bacteria Against Levofloxacin via Nanotechnology and Essential Oils

Journal of Pharmaceutical Innovation, Journal Year: 2024, Volume and Issue: 20(1)

Published: Dec. 24, 2024

Abstract Introduction The generation of biofilms by bacteria has become a major factor in the rise antibiotic resistance. Lipid nano-capsules (LNCs) have recently emerged as an innovative platform for drug delivery, due to their unique properties and ability carry wide array therapeutic chemical compounds. Objectives objective this research was create, optimize, evaluate antibiofilm efficacy peppermint oil emulsion (o/w) containing levofloxacin against resistant via biofilm formation. Methods Essential oils, particularly known its antifungal properties, were employed instead traditional medium chain triglycerides formulate lipid nanocarriers, utilizing alternating surfactant types (Solutol HS 15 Cremophor EL) differing ratios (2:1 1:1). LFX-LNCs formula, with 2:1 ratio, selected further investigation physical including particle size, zeta potential, transmission electron microscopy, polydispersity index. antibacterial efficiency evaluated, revealing eradicate established Gram-negative pathogens, Escherichia coli (E. coli) Pseudomonas aeruginosa (P. aeruginosa), well Gram-positive strains such Staphylococcus aureus (S. aureus). Results mean size varied from 30.86 ± 0.54 nm 68.36 0.56 nm, demonstrating narrow distribution, negative potential (-1.56 0.24 -20.2 2.15 mV), index (PDI) ranging 0.062 0.006 0.26 0.002. nanocapsules generally exhibit spherical morphology within nanometric range when analyzed microscopy (TEM). antimicrobial activity assessment revealed that EL exhibited most significant efficacy, characterized reduced inhibition zone measuring up (2.43 cm), promising results several pathogenic strains, P. , S. E. . Conclusion This study illustrates treatment non-healing wounds infected biofilm-forming bacteria. Graphical

Language: Английский

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Preparation and Evaluation of Complexed Ubiquinone (Coenzyme Q10) Antiaging Hyaluronic Acid–Vitamin C Serum for Skin Care

Journal of Cosmetic Dermatology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 30, 2024

Coenzyme Q10 (CoQ10) is widely recognized for its powerful antioxidant properties, sparking considerable interest in application within skincare treatments. However, inherently poor water solubility has posed a major challenge formulating effective products.

Language: Английский

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