Clinical and immunological characteristics of COVID-19 in patients with disease dynamics DOI Creative Commons
Yana Aleksandrovna Safronova, Aleksandr Sergeevich Pankov,

Marya Alexandrovna Charkina

et al.

Science and Innovations in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

The aim is to study the clinical and immunological indicators of COVID-19 in dynamics disease with determination predictors development changes lungs. Materials methods. object was 35 patients aged 22 75 years acute period disease, divided into two groups according identified disorders. Markers cellular (CD-3, CD-4, CD-8, CD-19) humoral immunity, cytokines (IL-6,8, TGF-β, TNF-α), CEC were determined all examined patients. Statistical processing obtained results carried out using computer program Statistica 10.0. Results. It found that subjects retained during entire follow-up period, which indicates an ongoing disease. At same time, significant differences severity individuals revealed, taking account age presence chronic somatic pathology, expressed primarily violation parameters T-system immunity. In postcovoid lungs, characteristic features age. Conclusions. A detected immune system may indicate persistence virus, means a prolongation specific inflammatory response risk extensive tissue damage. Within three months after recovery, tendency towards formation immunity persists both groups, occurs by end 1 month continues throughout period. group for pneumofibrosis outcome new coronavirus infection, combination IL-8 TGF-β most optimal, despite their decrease compared

Language: Английский

Clinical and immunological characteristics of COVID-19 in patients with disease dynamics DOI Creative Commons
Yana Aleksandrovna Safronova, Aleksandr Sergeevich Pankov,

Marya Alexandrovna Charkina

et al.

Science and Innovations in Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 27, 2024

The aim is to study the clinical and immunological indicators of COVID-19 in dynamics disease with determination predictors development changes lungs. Materials methods. object was 35 patients aged 22 75 years acute period disease, divided into two groups according identified disorders. Markers cellular (CD-3, CD-4, CD-8, CD-19) humoral immunity, cytokines (IL-6,8, TGF-β, TNF-α), CEC were determined all examined patients. Statistical processing obtained results carried out using computer program Statistica 10.0. Results. It found that subjects retained during entire follow-up period, which indicates an ongoing disease. At same time, significant differences severity individuals revealed, taking account age presence chronic somatic pathology, expressed primarily violation parameters T-system immunity. In postcovoid lungs, characteristic features age. Conclusions. A detected immune system may indicate persistence virus, means a prolongation specific inflammatory response risk extensive tissue damage. Within three months after recovery, tendency towards formation immunity persists both groups, occurs by end 1 month continues throughout period. group for pneumofibrosis outcome new coronavirus infection, combination IL-8 TGF-β most optimal, despite their decrease compared

Language: Английский

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