Sensitization profile of adult patients with allergic bronchial asthma in the Rostov region
Molekulyarnaya Meditsina (Molecular medicine),
Journal Year:
2025,
Volume and Issue:
unknown, P. 31 - 39
Published: Feb. 13, 2025
Introduction.
Bronchial
asthma
is
a
heterogeneous
disease
involving
different
phenotypes.
The
allergic
phenotype
the
most
studied
model
of
asthma.
Identification
causally
significant
allergens
by
determining
allergen-specific
IgE
key
to
precision
medicine
in
allergy.
Microchip
technology
makes
it
possible
analyze
molecular
profiles
sensitization
patients
with
allergies,
identify
major
allergens,
and
develop
personalized
approaches
allergenic
immunotherapy.
Objective:
evaluate
profile
adult
bronchial
Rostov
region
southern
Russia
using
allergodiagnostics.
Material
methods.
In
an
open
multicenter
retrospective
cohort
non-randomized
study,
individual
maps
166
verified
diagnosis
who
underwent
allergodiagnostics
Allergy
Explorer
2
(ALEX2)
allergochip
method
were
analyzed.
Statistical
processing
results
was
carried
out
Microsoft
Office
Excel
2010
Statistica
10.0
for
Windows
software
package.
Results.
According
polysensitization
prevails
among
phenotype,
leading
value
pollen
has
been
established.
dominant,
clinically
100%
cases
are
weeds
(in
41.0%
examined),
which
allergen
ambrosia
Amb
1
(43.98%)
prevails,
followed
wormwood
Art
v
(23.49%).
cases,
tree
determines
subclinical
77.7%
only
22.3%.
high
frequency
cross-reactive
molecules
causes
IgE-mediated
reactions
plant
products
(fruits
[43.4%],
nuts
[30.7%]),
latex
[21.7%]).
Conclusion.
study
allowed
us
establish
spectrum
revealed
predominant
role
weed
development
seasonal
allergy
region,
determined
sensitization,
important
correct
selection
immunotherapy
future.
Language: Английский
Molecular analysis of sensitization by aeroallergens in adult patients with allergic bronchial asthma
Molekulyarnaya Meditsina (Molecular medicine),
Journal Year:
2025,
Volume and Issue:
unknown, P. 45 - 53
Published: April 7, 2025
Introduction.
Bronchial
asthma
is
an
inflammatory
disease
manifested
by
various
phenotypes.
The
most
studied
phenotype
of
allergic.
Molecular
allergodiagnostics
allergic
diseases
using
microchips
makes
it
possible
to
determine
the
molecular
profiles
sensitization
patients
with
asthma,
identify
priority
molecules
for
personalized
allergen-specific
immunotherapy.
Objective:
conduct
a
analysis
adult
bronchial
aeroallergens
in
Rostov
region
southern
Russia
Methods.
In
multicenter,
retrospective,
non-randomized
cohort
study,
data
from
Allergy
Explorer
2
(ALEX2)
allergy
chips
were
analyzed
166
asthma.
Statistical
processing
results
was
carried
out
Microsoft
Office
Excel
2010
and
Statistica
10.0
Windows
software
package.
Results.
showed
that
pollen
predominance
IgE-mediated
reaction
ragweed
common
–
increase
level
IgE
main
allergen
component
Amb
1
(pectate
lyase)
registered
73
(43.98%)
patients,
wormwood
Art
v
(defensin)
noted
39
(23.49%).
Sensitization
allergens
mold
yeast
fungi
recorded,
molecule
Alternaria
alternata
(Alt
1)
27
(16.27%),
less
often
enolase
protein
family
6)
(1.20%),
Cladosporium
herbarum
(Cla
h
8)
1.20%
(n=2),
rarely
Aspergillus
fumigatus,
superoxide
dismutase
(Asp
f
5
(3.01%)
examined
patients.
Among
fungi,
found
Malassezia
sympodialis:
(Mala
s
5)
(0.60%)
respectively.
Conclusion.
method
used
made
establish
not
only
spectrum
sensitization,
but
also
allergocomponents
play
causally
significant
role
development
simultaneous
period
flowering
herbs
sporulation
increases
antigenic
load,
which
contributes
Russia,
transformation
into
more
severe
forms,
expansion
mixed
sensitization.
Language: Английский