Probiotics in Depression Management: Efficacy, Mechanisms and Future Directions

Progress In Microbes & Molecular Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 15, 2025

Depression affects approximately 280 million people worldwide, representing a significant public health burden. It is characterized by persistent sadness, anhedonia, fatigue, sleep disturbances, cognitive dysfunction, and in severe cases, suicidal ideation. The pathophysiology often attributed to neurotransmitter imbalances, hypothalamic-pituitary-adrenal (HPA) axis inflammation. Recently, the gut-brain has garnered attention for its role mood regulation, suggesting that probiotic supplementation may influence depressive symptoms through gut microbiome modulation. Therefore, this review examines recent findings research gaps regarding efficacy of probiotics managing clinically diagnosed depression. Emerging demonstrates daily from 3×109 CFU 9×1011 four eight weeks combination with antidepressants effective improving symptoms. Effective formulations commonly included Bifidobacteria, Lactobacilli, Lactococcus lactis, Streptococcus thermophilus. Nevertheless, remain, particularly concerning mechanistic pathways, comparative effectiveness, impact across different demographics probiotics. Furthermore, long-term effects use antidepressants, their reducing antidepressant side effects, combined psychotherapy are largely understudied. Addressing these standardized methodologies will enhance evaluations strains optimize microbiome-based treatment regimens, ultimately improve mental outcomes depression management. Graphical abstract. Summary future directions determine

Language: Английский

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Gut Microbiome and Symptom Burden in Obese and Non-Obese Women Receiving Chemotherapy for Breast Cancer

Biological Research For Nursing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Purpose: Obese women with breast cancer experience high symptom burden, poor quality of life, and increased mortality compared to non-obese cancer. Obesity-related changes the bacteria gut, GI microbiome, may be one such mechanism for these differences in outcomes. The purpose this work is report burden microbiome composition between obese identify potential microbial influences severity. Methods: 59 (26 obese, 33 non-obese) provided reports using Memorial Symptom Assessment Scale stool samples 16S analysis week after receiving chemotherapy. were summarized examined based on obesity. Fecal was groups alpha-diversity (Shannon index), beta-diversity (Principal Coordinate Analysis weighted UniFrac distances), LASSO abundance bacterial species. Results: While high, it did not differ obesity status. Alpha- find significant obesity, but identified eight significantly enriched participants: Collinsella aerofacien, Prevotella 7, Coprobacillus cateniformis, Ruminococcus torques group, Agathobacter, Frisingicoccus, Roseburia inulinivorans, Monoglobus pectinilyticus. Conclusions: Identifying biologic mechanisms driving symptoms necessary development therapies reduce cancer-related burden. alter influence cancer, effects outweighed by chemotherapy gut.

Language: Английский

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TphPMF: A microbiome data imputation method using hierarchical Bayesian Probabilistic Matrix Factorization

PLoS Computational Biology, Journal Year: 2025, Volume and Issue: 21(3), P. e1012858 - e1012858

Published: March 11, 2025

In microbiome research, data sparsity represents a prevalent and formidable challenge. Sparse not only compromises the accuracy of statistical analyses but also conceals critical biological relationships, thereby undermining reliability conclusions. To tackle this issue, we introduce machine learning approach for imputation, termed TphPMF. This technique leverages Probabilistic Matrix Factorization, incorporating phylogenetic relationships among microorganisms to establish Bayesian prior distributions. These priors facilitate posterior predictions potential non-biological zeros. We demonstrate that TphPMF outperforms existing imputation methods in accurately recovering missing taxon abundances. Furthermore, enhances efficacy certain differential abundance analysis detecting differentially abundant (DA) taxa, particularly showing advantages when used conjunction with DESeq2-phyloseq. Additionally, significantly improves precision cross-predicting disease conditions datasets pertaining type 2 diabetes colorectal cancer.

Language: Английский

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The Role of Beneficial Microbiota in COVID-19: Insights from Key Bacterial Genera

Microorganisms, Journal Year: 2025, Volume and Issue: 13(5), P. 1029 - 1029

Published: April 29, 2025

The COVID-19 pandemic has highlighted the need for a comprehensive understanding of factors influencing disease severity and progression. Emerging research indicates that human microbiota, particularly beneficial bacteria, significantly impacts immune responses health outcomes in patients. While existing studies provide general insights into relationship between microbiota probiotics with COVID-19, they often lack detailed exploration how specific bacterial taxa might be used as adjunctive treatments. This review aims to address this gap by focusing on ten key genera discussing their roles evaluating potential prevention treatment. covers impact these microbes health, population alterations patients, interactions other viral infections. Among microbes, several exhibit distinct patterns abundance highlighting infection dynamics. In populations Akkermansia, Ruminococcus, Roseburia are consistently reduced, while those Faecalibacterium show significant decline more severe cases. Bacteroides presents varying effects depending species involved. Alterations Blautia Lachnospiraceae associated increased inflammation severity. Likewise, depletion Lachnospira Coprococcus populations, both linked anti-inflammatory effects, may exacerbate symptom Oscillospira, though less studied, is connected overall could have implications synthesizes current highlight importance maintaining healthy alleviate contribute development novel therapeutic strategies involving modulation.

Language: Английский

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Microbiome Markers in Gastrointestinal Disorders: Inflammatory Bowel Disease, Colorectal Cancer, and Celiac Disease

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4818 - 4818

Published: May 17, 2025

Intestinal microbiota and the host’s immune system form a symbiotic alliance that sustains normal development function in human gut. Changes such as dietary habits among societies developed countries have led to of unbalanced microbial populations gut, likely contributing dramatic increase inflammatory diseases last few decades. Recent advances DNA sequencing technologies tremendously helped characterize microbiome associated with disease, both identifying global alterations discovering specific biomarkers potentially contribute disease pathogenesis, evidenced by animal studies. Beyond bacterial alterations, non-bacterial components fungi, viruses, metabolites been implicated these diseases, influencing responses gut homeostasis. Multi-omics approaches integrating metagenomics, metabolomics, transcriptomics offer more comprehensive understanding microbiome’s role paving way for innovative diagnostic therapeutic strategies. Unraveling metagenomic profiles may facilitate earlier diagnosis intervention, well personalized effective This review synthesizes recent relevant research studies aimed at characterizing signatures bowel colorectal cancer, celiac disease.

Language: Английский

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Genomic features and prevalence of Ruminococcus species in humans are associated with age, lifestyle, and disease

Cell Reports, Journal Year: 2024, Volume and Issue: 43(12), P. 115018 - 115018

Published: Nov. 29, 2024

Language: Английский

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Navigating the Role and Approach of Gut Microbiota in Addressing Alzheimer's Disease Pathogenesis

Progress In Microbes & Molecular Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Nov. 29, 2024

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by amyloid beta plaques and tau protein neurofibrillary tangles, leading to cognitive decline. The lack of effective treatments compounds the significant human financial burdens AD poses. Despite extensive research, exact mechanisms remain elusive. Recent studies have shown promise in using anti-Aβ antibodies reduce accumulation slow dementia progression. However, diversifying therapeutic strategies crucial for making meaningful progress. In recent years, research has increasingly focused on microbiota-gut-brain axis AD. Mounting evidence suggests that changes gut microbiota composition are linked progression, implicating various pathways. Dysregulation taxa can trigger systemic inflammation increasing permeability, ultimately neural damage neurodegeneration. Poor dietary habits aging exacerbate dysbiosis, worsening pathology. investigations this area still their early stages, with many aspects awaiting exploration understanding. A thorough comprehension complex interactions within microbiota-AD relationship essential refining approaches. Interventions targeting microbiota, such as adjustments, probiotics, faecal transplantation, offer potential therapeutics. This review highlights detrimental role dysbiosis AD, offering insights into enhancing avenues disease. Graphical abstract: bidirectional interaction between brain through neuroendocrine, immune, metabolic Created BioRender.com

Language: Английский

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In Silico Analysis of Probiotic Bacteria Changes Across COVID-19 Severity Stages

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2353 - 2353

Published: Nov. 18, 2024

The gut microbiota plays a crucial role in modulating the immune response during COVID-19, with several studies reporting significant alterations specific bacterial genera, including

Language: Английский

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