THE MOLECULAR MECHANISM, TYPES AND TREATMENT OF SCAR FORMATION DOI Open Access

Enver Tekin

Izmir Democracy University Health Sciences Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Wound healing and scar formation is a complex biological process that occurs as response to injury, characterized by the deposition of extracellular matrix components proliferation fibroblasts. The mechanisms underlying wound following can vary significantly depending on type scar, such hypertrophic scars keloids, are influenced various cellular molecular factors. Myofibroblasts, differentiated form fibroblasts, play pivotal role in due their contractile properties ability produce large amounts collagen other components. Scar involves interactions among cell types, including macrophages, endothelial cells, well Understanding these crucial for developing therapeutic strategies minimize pathological scarring, keloids. initial phase dominated inflammation, which essential initiating process. Inflammatory particularly orchestrating response. Fibroblasts primary effector cells formation, responsible synthesizing components, collagen. Scars be classified into several types based characteristics, mechanisms, clinical presentations. two most commonly discussed but there also atrophic scars, contracture acne each with distinct features implications treatment. aim this study explain mechanism, treatment formation.

Language: Английский

Stiffened fibre-like microenvironment based on patterned equidistant micropillars directs chondrocyte hypertrophy DOI Creative Commons
Mengmeng Duan, Shuang Xia, Yang Liu

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100682 - 100682

Published: May 27, 2023

Articular cartilage, composed of collagen type II as a major extracellular matrix and chondrocyte unique cell type, is specialized connective tissue without blood vessels, lymphatic vessels nerves. This distinctive characteristic articular cartilage determines its very limited ability to repair when damaged. It well known that physical microenvironmental signals regulate many behaviors such morphology, adhesion, proliferation communication even determine fate. Interestingly, with increasing age or progression joint diseases osteoarthritis (OA), the fibrils in become larger diameter, leading stiffening reducing resistance external tension, which turn aggravates damage diseases. Therefore, designing microenvironment closer real thus obtaining data cellular behaviour, then revealing biological mechanisms chondrocytes pathological states crucial importance for treatment OA disease. Here we fabricated micropillar substrates same topology but different stiffnesses mimic occurs transition from normal diseased cartilage. was first found responded stiffened by showing spreading area, stronger enhancement cytoskeleton rearrangement more stability focal adhesion plaques. The activation Erk/MAPK signalling detected response substrate. nuclear area at interface layer between cells top surfaces micropillars observed Finally, it substrate promoted hypertrophy. Taken together, these results revealed responses terms cytoskeleton, nuclei hypertrophy, may be beneficial understanding functional changes affected during state osteoarthritis.

Language: Английский

Citations

11
Molecular Mechanisms and Therapeutic Implications of Long Non‐coding RNAs in Cutaneous Biology and Disease DOI Open Access
Alessandro Zuccotti,

Farah Al‐Fatyan,

Giulia D. S. Ferretti

et al.

Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(2)

Published: Feb. 1, 2025

ABSTRACT Human skin is the largest organ of human body and accounts for approximately fifteen percent total bodyweight. Its main physiological role to protect against a wide range environmental factors including pathogens, ultraviolet light, injury. Importantly, can regenerate heal upon injury in large part by differentiation keratinocytes. Not surprisingly, dysregulation cutaneous self‐renewal result variety skin‐related pathologies, autoimmune disease cancer. Increasing evidence supports premise that long non‐coding RNAs (lncRNAs) act as critical mediators gene expression regulate important biological processes within skin. Notably, lncRNAs has been shown influence diverse pathological consequences. More recently, numerous reports have revealed new mechanistic insight on play homeostasis well their contribution pathogenesis disorders. Here, we review functions impact homeostasis. We also describe fundamental roles disorders, fibrotic, autoimmune, malignant diseases. Lastly, will highlight how better understanding at molecular level may reveal novel therapeutic approaches improvement

Language: Английский

Citations

0
Enhancement of Ndrg2 promotes hypertrophic scar fibrosis by regulating PI3K/AKT signaling pathway DOI

Boya Yu,

Yalei Cao,

Pianpian Lin

et al.

Cellular Signalling, Journal Year: 2025, Volume and Issue: unknown, P. 111659 - 111659

Published: Feb. 1, 2025

Language: Английский

Citations

0
The widespread misuse of StringTie’s gene identifier tags as de facto gene symbols does not allow consistent gene identification in published research DOI
Liana Alves de Oliveira, Gabriela Canalli Kretzschmar,

Sara Cristina Lobo‐Alves

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149440 - 149440

Published: March 1, 2025

Language: Английский

Citations

0
HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8 DOI

Fang Ma,

Honglin Liu,

Tongtong Xia

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 1, 2023

Hypertrophic scar (HS) is one of the most common sequelae patients, especially after burns and trauma. The roles regulatory long noncoding RNAs (lncRNAs) in mediating HS remain underexplored. Human hypertrophic scar-derived fibroblasts (HSFBs) have been shown to exert more potent promoting effects on extracellular matrix (ECM) accumulation than normal skin-derived (NSFBs) are associated with enhanced formation. purpose this study search for lncRNAs enriched HSFBs investigate their mechanisms. LncRNA MSTRG.59347.16 highly expressed detected by lncRNA-seq qRT-PCR named as fibroblast-associated lncRNA (HSFAS). HSFAS overexpression significantly induces fibroblast proliferation, migration, myofibroblast trans-differentiation inhibits apoptosis HSFBs, while knockdown

Language: Английский

Citations

2
LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar DOI Creative Commons
Kai Wu,

Fang Ma,

Jiangyong Shen

et al.

Acta Biochimica et Biophysica Sinica, Journal Year: 2022, Volume and Issue: 54(12), P. 1854 - 1862

Published: Dec. 1, 2022

Long noncoding RNAs (lncRNAs) are increasingly being implicated as key regulators of cell proliferation, apoptosis, and differentiation. However, the molecular mechanisms specific lncRNAs in context hypertrophic scar remain largely unclear. Here, we find that lncRNA FPASL (fibroblast proliferation-associated LncRNA) is downregulated HS, reduces fibroblast proliferation colony formation blocks cycle progression. Using GO annotation enrichment analysis along with AZC (a inhibitor DNA methylation), identify methylation responsible for downregulating scar. Subsequent studies demonstrate high expression DNMT3b inhibits HS. Mechanistic study reveals a significant increase after transfection LNA-FPASL, which further inhibited by knockdown DNMT3b. Thus, our mediates hypermethylation promoter downregulation promotes

Language: Английский

Citations

4
Exploring the potential mechanism of WuFuYin against hypertrophic scar using network pharmacology and molecular docking DOI
Shuyang Zhang, Songxue Guo, Leilei Chen

et al.

World Journal of Clinical Cases, Journal Year: 2024, Volume and Issue: 12(18), P. 3505 - 3514

Published: June 18, 2024

Hypertrophic scar (HTS) is dermal fibroproliferative disorder, which may cause physiological and psychological problems. Currently, the potential mechanism of WuFuYin (WFY) in treatment HTS remained to be elucidated.

Language: Английский

Citations

0
Hypertrophic Scar Treatment: Current Status and Cutting-Edge Advances DOI

晨 杨

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(09), P. 347 - 353

Published: Jan. 1, 2024

Language: Английский

Citations

0
THE MOLECULAR MECHANISM, TYPES AND TREATMENT OF SCAR FORMATION DOI Open Access

Enver Tekin

Izmir Democracy University Health Sciences Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Wound healing and scar formation is a complex biological process that occurs as response to injury, characterized by the deposition of extracellular matrix components proliferation fibroblasts. The mechanisms underlying wound following can vary significantly depending on type scar, such hypertrophic scars keloids, are influenced various cellular molecular factors. Myofibroblasts, differentiated form fibroblasts, play pivotal role in due their contractile properties ability produce large amounts collagen other components. Scar involves interactions among cell types, including macrophages, endothelial cells, well Understanding these crucial for developing therapeutic strategies minimize pathological scarring, keloids. initial phase dominated inflammation, which essential initiating process. Inflammatory particularly orchestrating response. Fibroblasts primary effector cells formation, responsible synthesizing components, collagen. Scars be classified into several types based characteristics, mechanisms, clinical presentations. two most commonly discussed but there also atrophic scars, contracture acne each with distinct features implications treatment. aim this study explain mechanism, treatment formation.

Language: Английский

Citations

0