Targeted drug delivery systems for atherosclerosis

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 23, 2025

Atherosclerosis is a complex cardiovascular disease driven by multiple factors, including aging, inflammation, oxidative stress, and plaque rupture. The progression of this often covert, emphasizing the need for early biomarkers effective intervention measures. In recent years, advancements in therapeutic strategies have highlighted potential targeting specific processes atherosclerosis, such as localization, macrophage activity, key enzymes. Based on this, review discusses role targeted drugs treatment atherosclerosis. It also focuses their clinical efficacy anti-atherosclerosis ability to provide more precise approaches. findings underscore that future research can concentrate exploring newer drug delivery systems further refine enhance long-term dynamic management

Language: Английский

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Dapagliflozin activates the RAP1B/NRF2/GPX4 signaling and promotes mitochondrial biogenesis to alleviate vascular endothelial ferroptosis

Cellular Signalling, Journal Year: 2025, Volume and Issue: 132, P. 111824 - 111824

Published: April 23, 2025

Language: Английский

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The Role of ROS in Atherosclerosis and ROS-Based Nanotherapeutics for Atherosclerosis: Atherosclerotic Lesion Targeting, ROS Scavenging, and ROS-Responsive Activity

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: May 23, 2025

Language: Английский

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Canagliflozin Inhibits Palmitic Acid-Induced Vascular Cell Aging In Vitro through ROS/ERK and Ferroptosis Pathways

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 831 - 831

Published: July 11, 2024

Vascular aging is one of the reasons for high incidence cardiovascular diseases nowadays, as vascular cells age due to various internal and external factors. Among them, fat an important inducer. Canagliflozin (CAN) SGLT2 inhibitors that has been shown have protective effects in addition lowering blood sugar, but specific mechanism not clear. This study first established a model using palmitic acid (PA), then tested effect CAN on PA-induced aging, finally examined CAN's anti-vascular via ROS/ERK ferroptosis pathways. We found alleviates cell by inhibiting activation signaling reveals new mechanisms lipid-induced inhibition from perspectives pathways, which expected provide ideas development related drugs future.

Language: Английский

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Acrolein-Triggered Ferroptosis and Protection by Intermittent Fasting via the AMPK/NRF2-CLOCK/BMAL1 Pathway

Toxics, Journal Year: 2025, Volume and Issue: 13(5), P. 369 - 369

Published: May 1, 2025

Environmental pollution significantly exacerbates various diseases, particularly those affecting the cardiovascular and respiratory systems. Our previous studies have shown that acrolein, an environmental pollutant, promotes atherosclerosis by downregulating circadian clock genes (CLOCK/BMAL1) disrupting rhythm. We also found intermittent fasting (IF), closely linked to clock, may mitigate induced acrolein. Ferroptosis, a newly identified form of regulated cell death, is associated with acceleration atherosclerotic development, but its relationship not well understood. In this study, we explored potential IF alleviate ferroptosis modulating clock. in vivo experiments revealed reversed upregulated CLOCK/BMAL1 APOE-/- mice. human umbilical vein endothelial cells (HUVECs), discovered acrolein-induced leads while short-term starvation (STS, model) effect. Acrolein suppressed expression AMP-activated protein kinase (AMPK), nuclear factor erythroid 2-related 2 (NRF2), CLOCK/BMAL1, which were restored subsequent STS treatments. Additionally, overexpression mitigated ferroptosis, consistent findings from CLOCK gene knockout experiments. Notably, AMPK/NRF2 be mutually regulated. Concurrently, AMPK NRF2 signaling pathways interdependent act concert. conclusion, our suggest modulates CLOCK/BMAL1-AMPK/NRF2 pathway offering strategy address health issues related pollution.

Language: Английский

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Reactive Oxygen Species and Mitochondrial Calcium's Roles in the Development of Atherosclerosis

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(23), P. 1812 - 1821

Published: May 28, 2024

In the last decade, there has been increasing evidence connecting mitochondrial dysfunction to onset and advancement of atherosclerosis. Both reactive oxygen species (ROS) disruption calcium (Ca

Language: Английский

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F-53B stimulated vascular smooth muscle cell phenotypic switch and vascular remodeling via ferroptosis-related pathway

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 954, P. 176565 - 176565

Published: Sept. 27, 2024

Language: Английский

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Isopropyl 3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoate Alleviates Palmitic Acid-Induced Vascular Aging in HUVEC Cells through ROS/Ferroptosis Pathway

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9278 - 9278

Published: Aug. 27, 2024

Vascular aging is an important factor leading to cardiovascular diseases such as hypertension and atherosclerosis. Hyperlipidemia or fat accumulation may play role in vascular disease. Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate (IDHP) has biological activity can exert protection, which be related ferroptosis. However, the exact mechanism remains undefined. We hypothesized that IDHP have a protective effect on blood vessels by regulating caused hyperlipidemia wall accumulation. The aim of this study investigate palmitic acid-induced human umbilical vein endothelial cells (HUVEC) based senescence found could delay aging, reduce degree ferrous ion lipid peroxidation, protect from injury. These effects achieved attenuating excessive reactive oxygen species (ROS) ferroptosis signaling pathways generated cells. In short, our identified one antioxidant agents slow down lipotoxicity-induced through ROS/ferroptosis pathway. new medicinal value provides therapeutic idea for delaying patients with dyslipidemia.

Language: Английский

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Inhibition of CTLA-4 accelerates atherosclerosis in hyperlipidemic mice by modulating the Th1/Th2 balance via the NF-κB signaling pathway

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37278 - e37278

Published: Aug. 31, 2024

Though an increased risk of atherosclerosis is associated with anti-CTLA-4 antibody therapy, the underlying mechanisms remain unclear.

Language: Английский

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Itchy E3 Ubiquitin Ligase-Mediated Ubiquitination of Ferritin Light Chain Contributes to Endothelial Ferroptosis in Atherosclerosis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13524 - 13524

Published: Dec. 17, 2024

This research seeks to investigate the function and fundamental mechanisms of Itchy E3 ubiquitin ligase (ITCH), a HECT (homologous E6AP carboxyl terminus)-type ligase, in endothelial ferroptosis, particularly context atherosclerosis, which has been underexplored. The levels ITCH protein aortas mice with atherosclerosis were analyzed. Constructs for RNA interference generated introduced into human aortic cells (HAECs). findings indicated that expression was elevated atherosclerotic HAECs exposed oxidized low-density lipoprotein (ox-LDL). downregulation significantly mitigated ox-LDL-induced injury dysfunction. Reducing inhibited ferroptosis. study also revealed mediates ubiquitin-dependent degradation ferritin light chain (FTL) HAECs. protective impact knockdown against ferroptosis reversed by FTL siRNA. Additionally, vivo experiments showed inhibiting reduced progression aorta, an associated increase mice. demonstrates interacts regulates stability via ubiquitin-proteasome system, contributing cell Targeting components ITCH-FTL pathway holds potential as therapeutic strategy atherosclerosis.

Language: Английский

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