Establishment of a prognostic model for pancreatic cancer based on mitochondrial metabolism related genes DOI Creative Commons

Qinwen Ba,

Xiong Wang,

Yanjun Lu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 28, 2024

Pancreatic ductal adenocarcinoma (PAAD) is recognized as an exceptionally aggressive cancer that both highly lethal and unfavorable prognosis. The mitochondrial metabolism pathway intimately involved in oncogenesis tumor progression, however, much remains unknown this area. In study, the bioinformatic tools have been used to construct a prognostic model with metabolism-related genes (MMRGs) evaluate survival, immune status, mutation profile, drug sensitivity of PAAD patients.

Language: Английский

Identification and preliminary validation of biomarkers associated with mitochondrial and programmed cell death in pre-eclampsia DOI Creative Commons
Rong Lin, Xisheng Weng, Liang Lin

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 23, 2025

Background The involvement of mitochondrial and programmed cell death (mtPCD)–related genes in the pathogenesis pre-eclampsia (PE) remains inadequately characterized. Methods This study explores role mtPCD PE through bioinformatics experimental approaches. Differentially expressed were identified as potential biomarkers from GSE10588 GSE98224 datasets subsequently validated. Hub determined using support vector machine, least absolute shrinkage selection operator, Boruta based on consistent expression profiles. Their performance was assessed nomogram artificial neural network models. Biomarkers subjected to localization, functional annotation, regulatory analysis, drug prediction. Clinical validation conducted via real-time quantitative polymerase chain reaction (RT-qPCR), immunofluorescence, Western blot. Results Four [solute carrier family 25 member 5 ( SLC25A5 ), acyl-CoA synthetase 2 ACSF2 fission factor MFF phorbol-12-myristate-13-acetate–induced protein 1 PMAIP1 )] distinguishing normal controls. Functional analysis indicated their various biological pathways. Immune revealed associations between immune activity. A informed by biomarker database predictions, which KCNQ1OT1 modulates hsa-miR-200b-3p. Drug including clodronic acid, also proposed. Immunofluorescence, RT-qPCR, blot confirmed reduced SLC25A5, , PE, whereas significantly upregulated. Conclusion These four mtPCD-related may play a pivotal pathogenesis, offering new perspectives disease’s diagnostic mechanistic

Language: Английский

Citations

0
Targeted mitochondrial therapy for pancreatic cancer DOI
Xinya Zhao, Guoyu Wu,

Xufeng Tao

et al.

Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102340 - 102340

Published: March 5, 2025

Language: Английский

Citations

0
NLRP3 inflammasome-based therapies by natural products: a new development in the context of cancer therapy DOI
Hamza Abu Owida, Ahmed Abed, Farag M. A. Altalbawy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Language: Английский

Citations

0
Mitochondrial Dynamics Regulators in Cancer Metabolism and Progression DOI Creative Commons
Ahmed Shaaban,

Al-Hassan Soliman Wadan,

Mohamed El‐Sadek

et al.

Mitochondrial Communications, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Establishment of a prognostic model for pancreatic cancer based on mitochondrial metabolism related genes DOI Creative Commons

Qinwen Ba,

Xiong Wang,

Yanjun Lu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Aug. 28, 2024

Pancreatic ductal adenocarcinoma (PAAD) is recognized as an exceptionally aggressive cancer that both highly lethal and unfavorable prognosis. The mitochondrial metabolism pathway intimately involved in oncogenesis tumor progression, however, much remains unknown this area. In study, the bioinformatic tools have been used to construct a prognostic model with metabolism-related genes (MMRGs) evaluate survival, immune status, mutation profile, drug sensitivity of PAAD patients.

Language: Английский

Citations

0