Transitioning adolescents and young adults with asthma: insights from a severe asthma series DOI

Alessandro Dorato,

Rosa Buonagura,

Melissa Borrelli

et al.

Published: April 14, 2025

Thanks to improvements in asthma care and availability of new biologic treatments, a relatively novel population adolescents young adults (AYA) with severe (SA) is growing. Transition from pediatric adult represents critical phase the management SA. We herein describe clinical outcomes, therapeutic adjustments disease group SA patients transitioning center. This retrospective study which demographic (comorbidities, baseline treatment, number attacks, spirometry, airway inflammation [fractional exhaled nitric oxide (FeNO) measurements], patient’s compliance) data four during visits Pediatric center as well after transition into Adult Center, were retrospectively recollected. All transitioned at 18 years age. Clinical parameters, spirometry FeNO showed significant improvement following addition biologics regimen follow-up early phase. Several months two males experienced exacerbations voluntary discontinuation treatment. Symptom control was gained phenotype driven re-introduction drug regimen. Male less compliant independent than females setting. for can be effectively managed coordinated structured processes. While some maintain stable respiratory others risk lose control. A personalized approach supporting both independence adherence treatment requested successful long-term management.

Language: Английский

Transitioning adolescents and young adults with asthma: insights from a severe asthma series DOI

Alessandro Dorato,

Rosa Buonagura,

Melissa Borrelli

et al.

Published: April 14, 2025

Thanks to improvements in asthma care and availability of new biologic treatments, a relatively novel population adolescents young adults (AYA) with severe (SA) is growing. Transition from pediatric adult represents critical phase the management SA. We herein describe clinical outcomes, therapeutic adjustments disease group SA patients transitioning center. This retrospective study which demographic (comorbidities, baseline treatment, number attacks, spirometry, airway inflammation [fractional exhaled nitric oxide (FeNO) measurements], patient’s compliance) data four during visits Pediatric center as well after transition into Adult Center, were retrospectively recollected. All transitioned at 18 years age. Clinical parameters, spirometry FeNO showed significant improvement following addition biologics regimen follow-up early phase. Several months two males experienced exacerbations voluntary discontinuation treatment. Symptom control was gained phenotype driven re-introduction drug regimen. Male less compliant independent than females setting. for can be effectively managed coordinated structured processes. While some maintain stable respiratory others risk lose control. A personalized approach supporting both independence adherence treatment requested successful long-term management.

Language: Английский

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