Combating antibiotic resistance: mechanisms, challenges, and innovative approaches in antibacterial drug development DOI Creative Commons

Aiswarya Rajesh,

Sunita Pawar,

Kruthi Doriya

et al.

Published: Jan. 26, 2025

Antibiotic resistance is a significant threat to public health and drug development, driven largely by the overuse misuse of antibiotics in medical agricultural settings. As bacteria adapt evade current drugs, managing bacterial infections has become increasingly challenging, leading prolonged illnesses, higher healthcare costs, increased mortality. This review explores critical role fighting mechanisms that enable resist them. Key discussed include carvacrol, dalbavancin, quinolones, fluoroquinolones, zoliflodacin, each with unique actions against pathogens. Bacteria have evolved complex strategies, such as enzyme production neutralize modifying targets, using efflux pumps remove antibiotics, significantly reducing efficacy. Additionally, examines challenges antibiotic including declining discovery rate novel drugs due high costs regulatory complexities. Innovative approaches, structure-based design, combination therapies, new delivery systems, are highlighted for their potential create compounds enhanced action resistant strains. provides valuable insights researchers developers aiming combat advance development robust antibacterial therapies future security.

Language: Английский

Combating antibiotic resistance: mechanisms, challenges, and innovative approaches in antibacterial drug development DOI Creative Commons

Aiswarya Rajesh,

Sunita Pawar,

Kruthi Doriya

et al.

Published: Jan. 26, 2025

Antibiotic resistance is a significant threat to public health and drug development, driven largely by the overuse misuse of antibiotics in medical agricultural settings. As bacteria adapt evade current drugs, managing bacterial infections has become increasingly challenging, leading prolonged illnesses, higher healthcare costs, increased mortality. This review explores critical role fighting mechanisms that enable resist them. Key discussed include carvacrol, dalbavancin, quinolones, fluoroquinolones, zoliflodacin, each with unique actions against pathogens. Bacteria have evolved complex strategies, such as enzyme production neutralize modifying targets, using efflux pumps remove antibiotics, significantly reducing efficacy. Additionally, examines challenges antibiotic including declining discovery rate novel drugs due high costs regulatory complexities. Innovative approaches, structure-based design, combination therapies, new delivery systems, are highlighted for their potential create compounds enhanced action resistant strains. provides valuable insights researchers developers aiming combat advance development robust antibacterial therapies future security.

Language: Английский

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