The Role of RAC2 and PTTG1 in Cancer Biology DOI Creative Commons
Katarzyna Rakoczy, Natalia Szymańska, Jakub Stecko

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 330 - 330

Published: Feb. 23, 2025

Several molecular pathways are likely involved in the regulation of cancer stem cells (CSCs) via Ras-associated C3 botulinum toxin substrate 2, RAC2, and pituitary tumor-transforming gene 1 product, PTTG1, given their roles cellular signaling, survival, proliferation, metastasis. RAC2 is a member Rho GTPase family plays crucial role actin cytoskeleton dynamics, reactive oxygen species production, cell migration, contributing to epithelial-mesenchymal transition (EMT), immune evasion, therapy resistance. also known as human securin, regulates key processes such cycle progression, apoptosis suppression, EMT, promoting metastasis enhancing survival. This article aims describe invasiveness, drug response through aiming clarify respective neoplastic process dependencies. Both proteins critical signaling pathways, including PI3K/AKT, TGF-β, NF-κB, which facilitate tumor progression by modulating CSC properties, angiogenesis, response. review highlights mechanisms PTTG1 influence tumorigenesis describes potential efficacy prognostic biomarkers therapeutic targets managing various neoplasms.

Language: Английский

The Role of RAC2 and PTTG1 in Cancer Biology DOI Creative Commons
Katarzyna Rakoczy, Natalia Szymańska, Jakub Stecko

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 330 - 330

Published: Feb. 23, 2025

Several molecular pathways are likely involved in the regulation of cancer stem cells (CSCs) via Ras-associated C3 botulinum toxin substrate 2, RAC2, and pituitary tumor-transforming gene 1 product, PTTG1, given their roles cellular signaling, survival, proliferation, metastasis. RAC2 is a member Rho GTPase family plays crucial role actin cytoskeleton dynamics, reactive oxygen species production, cell migration, contributing to epithelial-mesenchymal transition (EMT), immune evasion, therapy resistance. also known as human securin, regulates key processes such cycle progression, apoptosis suppression, EMT, promoting metastasis enhancing survival. This article aims describe invasiveness, drug response through aiming clarify respective neoplastic process dependencies. Both proteins critical signaling pathways, including PI3K/AKT, TGF-β, NF-κB, which facilitate tumor progression by modulating CSC properties, angiogenesis, response. review highlights mechanisms PTTG1 influence tumorigenesis describes potential efficacy prognostic biomarkers therapeutic targets managing various neoplasms.

Language: Английский

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