Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: July 7, 2022

Abstract Molecular oxygen (O 2 ) is essential for most biological reactions in mammalian cells. When the intracellular content decreases, it called hypoxia. The process of hypoxia linked to several processes, including pathogenic microbe infection, metabolic adaptation, cancer, acute and chronic diseases, other stress responses. mechanism underlying cells respond changes mediate subsequent signal response central question during Hypoxia-inducible factors (HIFs) sense regulate expressions a series downstream genes expression, which participate multiple processes cell metabolism, growth/death, proliferation, glycolysis, immune response, tumorigenesis, metastasis. Importantly, signaling also interacts with cellular pathways, such as phosphoinositide 3-kinase (PI3K)-mammalian target rapamycin (mTOR) signaling, nuclear factor kappa-B (NF-κB) pathway, extracellular signal-regulated kinases (ERK) endoplasmic reticulum (ER) stress. This paper systematically reviews mechanisms activation, control HIF function human health diseases. In addition, therapeutic targets involved balance diseases are summarized highlighted, would provide novel strategies design development drugs.

Language: Английский

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STIMULI-RESPONSIVE SUPRAMOLECULAR HYDROGELS FOR PACLITAXEL DELIVERY: PROGRESS AND PROSPECTS

Aspects of Molecular Medicine, Journal Year: 2025, Volume and Issue: 5, P. 100062 - 100062

Published: Jan. 5, 2025

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Molecular mechanisms behind ROS regulation in cancer: A balancing act between augmented tumorigenesis and cell apoptosis

Archives of Toxicology, Journal Year: 2022, Volume and Issue: 97(1), P. 103 - 120

Published: Nov. 28, 2022

Language: Английский

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The Promise of Nanoparticles-Based Radiotherapy in Cancer Treatment

Cancers, Journal Year: 2023, Volume and Issue: 15(6), P. 1892 - 1892

Published: March 22, 2023

Radiation has been utilized for a long time the treatment of cancer patients. However, radiotherapy (RT) many constraints, among which non-selectivity is primary one. The implementation nanoparticles (NPs) with RT not only localizes radiation in targeted tissue but also provides significant tumoricidal effect(s) compared to alone. NPs can be functionalized both biomolecules and therapeutic agents, their combination significantly reduces side effects RT. NP-based destroys cells through multiple mechanisms, including ROS generation, turn damages DNA other cellular organelles, inhibiting double-strand damage-repair system, obstructing cell cycle, regulating tumor microenvironment, killing stem cells. Furthermore, such combined treatments overcome radioresistance drug resistance chemotherapy. Additionally, have shown synergistic benefit(s) enhanced window. phototherapy, i.e., photodynamic therapy photothermal RT, phototoxicity offers excellent benefits. Moreover, using promise outcomes clinical trials. Therefore, extensive research this field will pave way toward improved treatment.

Language: Английский

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Synthesized Gold Nanoparticles with Moringa Oleifera leaf Extract Induce Mitotic Arrest (G2/M phase) and Apoptosis in Dalton’s Lymphoma Cells

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(2), P. 1043 - 1059

Published: May 2, 2024

Language: Английский

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Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 502 - 502

Published: Feb. 23, 2024

The fact that the Mediterranean diet could represent a source of natural compounds with cancer-preventive and therapeutic activity has been object great interest, especially regard to mechanisms action polyphenols found in olive oil leaves. Secoiridoid oleuropein (OLE) its derivative hydroxytyrosol (3,4-dihydroxyphenylethanol, HT) have demonstrated anti-proliferative properties against variety tumors hematological malignancies both vivo vitro, measurable effects on cellular redox status, metabolism, transcriptional activity. With this review, we aim summarize most up-to-date information potential use OLE HT for cancer treatment, making important considerations about bioavailability, OLE- HT-mediated drug dual as pro- antioxidants, likely hampering their clinical routine. Also, focus details available nutritionally relevant concentrations cell viability, homeostasis, inflammation order evaluate if be considered agents or new chemotherapy drugs whenever only is represented by diet.

Language: Английский

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Evaluation of regulatory T-cells in cancer immunotherapy: therapeutic relevance of immune checkpoint inhibition

Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)

Published: Jan. 18, 2024

Language: Английский

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Interweaving catalysis and cancer using Ru- and Os-arene complexes to alter cellular redox state: A structure-activity relationship (SAR) review

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 491, P. 215230 - 215230

Published: June 2, 2023

Language: Английский

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Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(17), P. 2571 - 2599

Published: May 5, 2023

Hepatocellular carcinoma (HCC) is one of the most lethal malignant tumours worldwide. The mortality-to-incidence ratio up to 91.6% in many countries, representing third leading cause cancer-related deaths. Systemic drugs, including multikinase inhibitors sorafenib and lenvatinib, are first-line drugs used HCC treatment. Unfortunately, these therapies ineffective cases due late diagnosis development tumour resistance. Thus, novel pharmacological alternatives urgently needed. For instance, immune checkpoint have provided new approaches targeting cells system. Furthermore, monoclonal antibodies against programmed cell death-1 shown benefits patients. In addition, drug combinations, treatment immunotherapy, as well repurposing, promising therapeutic alternatives. Here, we review current fight HCC. Preclinical studies, approved ongoing clinical trials for liver cancer treatment, discussed. opportunities analysed here should lead significant improvement therapy.

Language: Английский

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Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment

Molecules, Journal Year: 2023, Volume and Issue: 28(14), P. 5305 - 5305

Published: July 10, 2023

Breast cancer (BC) is a complex and heterogeneous disease, oxidative stress hallmark of BC. Oxidative characterized by an imbalance between the production reactive oxygen species (ROS) antioxidant defense mechanisms. ROS has been implicated in BC development progression inducing DNA damage, inflammation, angiogenesis. Antioxidants have shown to scavenge protect cells from thereby regulating signaling pathways involved cell growth, survival, death. Plants contain antioxidants like ascorbic acid, tocopherols, carotenoids, flavonoids, which found regulate PCD Combining different promise enhancing effectiveness treatment. Antioxidant nanoparticles, when loaded with antioxidants, can effectively target breast enhance their cellular uptake. Notably, these nanoparticles promising results sensitizing chemotherapy, even cases where resistance observed. This review aims explore how nanotechnology modulate cancer. By summarizing current research, it underscores potential properties for treatment

Language: Английский

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