Molecular Targets of Minor Cannabinoids in Breast Cancer: In Silico and In Vitro Studies
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(9), P. 1245 - 1245
Published: Sept. 21, 2024
Background:
Breast
cancer
therapy
has
been
facing
remarkable
changes.
Classic
treatments
are
now
combined
with
other
therapies
to
improve
efficacy
and
surpass
resistance.
Indeed,
the
emergence
of
resistance
demands
development
novel
therapeutic
approaches.
Due
key
estrogen
signaling,
receptor-positive
(ER+)
breast
treatment
always
focused
on
aromatase
inhibition
ER
modulation.
Lately,
effects
phytocannabinoids,
mainly
Δ9-tetrahydrocannabinol
(THC)
cannabidiol
(CBD),
have
evaluated
in
different
cancers,
including
breast.
However,
Cannabis
sativa
contains
more
than
120
phytocannabinoids
less
researched
understood.
Methods:
Here,
we
evaluated,
both
silico
vitro,
ability
129
modulate
important
molecular
targets
ER+
cancer:
aromatase,
ER,
androgen
receptor
(AR).
Results:
In
results
suggested
that
some
cannabinoids
may
inhibit
act
as
ERα
antagonists.
Nine
selected
showed,
potential
either
antagonists
inverse
agonist
properties,
or
agonists.
Moreover,
these
were
considered
weak
inhibitors
AR
action.
Conclusions:
Overall,
present,
for
first
time,
a
comprehensive
analysis
actions
tumors,
pointing
out
their
diseases.
Language: Английский
New Cannabinoids and Chlorin-Type Metabolites from the Flowers of Cannabis sativa L.: A Study on Their Neuroblastoma Activity
Nguyễn Quốc Tuấn,
No information about this author
Hee Sung Park,
No information about this author
Sung-Hoon Choi
No information about this author
et al.
Pharmaceuticals,
Journal Year:
2025,
Volume and Issue:
18(4), P. 521 - 521
Published: April 3, 2025
Background/Objectives:
Cannabis
sativa
has
been
utilized
for
medical
purposes
thousands
of
years.
It
continues
to
be
recognized
as
a
plant
with
an
extensive
variety
medicinal
and
nutraceutical
uses
today.
In
this
study,
chemical
investigation
the
flowers
C.
isolated
by
using
chromatographic
techniques
led
isolation
eleven
compounds.
These
purified
compounds
were
evaluated
antitumor
activity
against
SK-N-SH
neuroblastoma
cells.
Methods:
The
techniques.
Their
structures
identified
examination
spectroscopic
methods,
including
1D
(1H,
13C,
DEPT)
2D
(COSY,
HSQC,
HMBC,
NOESY)
nuclear
magnetic
resonance
(NMR)
spectra
mass
spectrum,
together
comparison
those
reported
previously
in
literature.
evaluation
toxicity
on
cells
was
performed
MTT
method.
Results:
Eleven
from
sativa,
two
new
compounds,
namely
cannabielsoxa
(1),
132-hydroxypheophorbide
c
ethyl
ester
(2),
six
known
cannabinoids
(6–11),
first
chlorin-type
compounds:
pyropheophorbide
A
(3),
b
(4),
ligulariaphytin
(5)
plant.
results
also
demonstrated
that
cannabinoid
had
stronger
inhibitory
effects
than
Conclusions:
biological
activities
showed
4–10
could
considered
potential
neuroblastomas.
This
is
highlighted
docking
analysis.
Additionally,
study
suggest
these
have
developed
into
antineuroblastoma
products.
Language: Английский