Regenerative medicine reports ., Journal Year: 2024, Volume and Issue: 1(1), P. 59 - 75
Published: Sept. 1, 2024
Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are chronic gastrointestinal disorders characterized by relapsing intestinal inflammation. In addition to symptoms, patients with inflammatory diseases experience a disproportionately high prevalence of depression other neuropsychiatric comorbidities. The gut–brain axis, bidirectional communication system between the gut brain, has emerged as potential pathogenic link underlying this aberrant mind–gut interplay. This review synthesizes growing evidence implicating axis dysregulation central mechanism bridging inflammation development in diseases. Regenerative medicine offers promising new avenues for addressing these complex conditions. By focusing on regenerative therapies that target we explore approaches could repair or restore normal function both brain. These might alleviate proper signaling via neural, immune-mediated, endocrine, microbiome-related pathways, ultimately reversing neurochemical, structural, functional brain abnormalities implicated depressive neuropathology. Unraveling interactions disease-related through profound translational implications, paving way transformative diagnostic therapeutic paradigms address multisystemic burden debilitating conditions holistically.
Language: Английский