Vaccines,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1271 - 1271
Published: July 21, 2023
The
hepatitis
A
virus
(HAV)
is
still
a
leading
cause
of
viral
worldwide.
After
long
incubation
period,
the
clinical
manifestations
range
from
asymptomatic
infection
to
acute
liver
failure.
severity
disease
increases
with
age
and
pre-existing
disease.
transmission
mainly
via
person-to-person
contact
or
ingestion
contaminated
food
water.
Food
contamination
can
occur
at
any
step
chain,
especially
when
infected
people
handle
not-heated
otherwise-treated
food.
HAV
endemic
in
low-income
countries
because
poor
sanitary
sociodemographic
conditions.
populations
developed
are
highly
susceptible,
large
outbreaks
introduced
due
globalization,
travel,
movement
foodstuffs.
prevention
includes
hygiene
practices,
immunoglobulins,
vaccination.
Safe
effective
inactivated
live
attenuated
vaccines
available
provide
long-term
protection.
vaccine
targets
children
subjects
increased
risk
exposure
serious
outcomes.
This
review
discusses
critical
role
handlers
spread
opportunity
for
industry
employers
consider
handler
immunization
tool
manage
both
safety
compliance
HACCP
principles
operators'
biologic
risk.
Journal of Clinical and Translational Hepatology,
Journal Year:
2023,
Volume and Issue:
11(7), P. 1542 - 1552
Published: Nov. 15, 2023
Peroxisome
proliferator-activated
receptors
(PPARs)
are
a
superfamily
of
nuclear
transcription
receptors,
consisting
PPARα,
PPARγ,
and
PPARβ/δ,
which
highly
expressed
in
the
liver.
They
control
modulate
expression
large
number
genes
involved
metabolism
energy
homeostasis,
oxidative
stress,
inflammation,
even
apoptosis
Therefore,
they
have
critical
roles
pathophysiology
hepatic
diseases.
This
review
provides
general
insight
into
role
PPARs
liver
diseases
some
their
agonists
clinic.
Human Vaccines & Immunotherapeutics,
Journal Year:
2025,
Volume and Issue:
21(1)
Published: Jan. 16, 2025
While
Hepatitis
A
Virus
(HAV)
vaccination
in
global
immunization
programs
has
shown
a
virtual
elimination
of
the
disease
within
few
years
program,
changing
epidemiological
landscape
India
underscores
need
for
evidence-based,
updated
guidance
on
practices.
In
May
2024,
panel
15
distinguished
opinion
leaders
and
an
organizing
committee
convened
intensive,
face-to-face
advisory
board
meeting
high
burden
HAV
infection
among
adults,
increased
mortality
rate
adolescents,
symptomatic
presentation
children,
evolving
globally
India.
Extensive
comparable
deliberations
long-term
follow-up
data
from
country
origin
advocated
immunogenicity,
tolerability,
protective
effects
single-dose
live
attenuated
vaccine
children.
Finally,
consensus
was
achieved
recognition
attention
toward
prevention
through
coverage.
The
single
dose
important
outcome
this
meeting.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(3), P. 348 - 348
Published: Jan. 21, 2025
Chronic
liver
diseases,
such
as
those
encountered
with
obesity,
chronic/abusive
alcohol
consumption
or
viral
infections,
represent
not
only
major
public
health
concerns
limited
therapeutic
options
but
also
important
risk
factors
for
the
onset
of
hepatocellular
carcinoma
(HCC).
Deciphering
molecular
traits
underlying
these
disorders
is
high
interest
designing
new
and
effective
treatments.
The
tristetraprolin
(TTP)
family
members
are
particular
importance
given
their
ability
to
control
expression
a
wide
range
genes
involved
in
metabolism,
inflammation
carcinogenesis
at
post-transcriptional
level.
This
regulation
can
occur
within
small
cytoplasmic
granules,
namely,
processing
bodies
(P-bodies),
where
mRNA
degradation
occurs.
Increasing
evidence
indicates
that
TTP
P-bodies
development
chronic
diseases
cancers.
In
this
review,
we
discuss
role
regulatory
mechanism
metabolic-dysfunction-associated
steatotic
disease
(MASLD),
alcohol-related
(ALD),
hepatic
infections
HCC.
