Impact of maternal COVID-19 infection on offspring immunity and maternal-fetal outcomes at different pregnancy stages: a cohort study

BMC Pregnancy and Childbirth, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 28, 2025

To investigate the impact of COVID-19 infection on maternal and neonatal outcomes immunity in pregnant women China. 283 with were included prospective observational cohort study divided into five groups based stage. Antibody levels measured plasma, umbilical cord blood, breast milk, combined clinical data 6-month follow-up results. We SARS-CoV-2 antibody using a chemiluminescence immunoassay analyzed Kruskal-Wallis test, χ2 or Fisher's exact test. No significant differences found age, BMI, weight change during pregnancy, incidence gestational hypertension, diabetes, hypothyroidism, intrahepatic cholestasis, transaminitis, preterm birth, small for NICU transfers, developmental delays, hearing damage among groups. The infants from mothers infected at different stages pregnancy was significantly lower than uninfected group (P < 0.05). Maternal blood showed higher IgG compared to median transplacental transfer ratio across all 1.15 (0.98–1.30), no between them. reinfection had IgA other adverse observed any stage infection. Antibodies milk may offer passive newborns 1–3 months. Reinfection extend this without raising risk outcomes.

Language: Английский

COVID-19 related liver injuries in pregnancy

World Journal of Clinical Cases, Journal Year: 2023, Volume and Issue: 11(9), P. 1918 - 1929

Published: March 16, 2023

While severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) quickly spread across the globe, our understanding of its pathogenic mechanisms evolved. Importantly, disease 2019 (COVID-19) is now considered a syndromic multisystem inflammatory involving not only system but also cardiovascular, excretory, nervous, musculoskeletal, and gastrointestinal systems. Moreover, membrane-bound form angiotensin-converting enzyme 2, entry receptor for SARS-CoV-2, expressed on surface cholangiocytes hepatocytes, suggesting potential COVID-19 to involve liver. With widespread distribution SARS-CoV-2 throughout population, infection during pregnancy no longer rare occurrence; however, little known about course hepatic injuries related outcomes in pregnant SARS-CoV-2-positive women. Thus, understudied topic COVID-related liver poses great challenge consulting gynecologist hepatologist. In this review, we aim describe summarize women with COVID-19.

Language: Английский

A Cross-sectional Assessment of Initial Liver Function Tests between Severe and Non-severe COVID-19 Patients and Its Correlation with In-hospital Outcomes: A Rural-based Single-center Study

Bengal Physician Journal, Journal Year: 2024, Volume and Issue: 11(3), P. 101 - 106

Published: Dec. 9, 2024

Language: Английский