The burden of metabolic dysfunction-associated steatotic liver disease and viral hepatitis in Saudi Arabia

Saudi Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(5), P. 310 - 318

Published: June 28, 2024

Globally, viral hepatitis is decreasing, but nonalcoholic fatty liver disease (NAFLD), now metabolic dysfunction-associated steatotic (MASLD), increasing. We assessed the burden and trends of MASLD in Saudi Arabia.

Language: Английский

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Biosocial Determinants of Health Among Patients with Chronic Liver Disease and Liver Cancer

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 844 - 844

Published: Feb. 28, 2025

Metabolic disorders and chronic liver disease (CLD) play crucial roles in the development progression of cancer (LC). Since ethnic minority population increasingly suffers from CLD LC, it is vital to understand biosocial factors contributing LC. The 'All Us' database, with significant participation populations, provides a valuable tool for studies different racial/ethnic groups. Using databases, including 'The Cancer Genome Atlas', this study aimed data, confounding like lack immunization, comorbidities, socioeconomic status (SES) barriers were analyzed cohort 33767 [non-alcoholic fatty disease, alcoholic Hepatitis B C] patients. Among 556 LC patients 92% had CLD. hypoxanthine known be increased urine patients, purine metabolic pathway genes using databases validated publicly available RNASeq data. We identified several associated Hispanic (HA) African American (AA) populations compared non-Hispanic White (NHW) populations. HA AA suffer high SES barriers. While most related upregulated xanthine dehydrogenase (XDH), which converts uric acid, showed downregulation tumor normal tissues. TCGA data among groups that only Asian (AN) tumors XDH expression was significantly lower NHW. decreased mRNA AN benign tissues further RNAseq datasets. Survival analysis confirmed poor overall survival their tumors. Our population. This also as critical alteration has clinical significance

Language: Английский

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Nanoparticle-based therapeutic strategies for chronic liver diseases: Advances and insights

Liver Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15212 - 15212

Published: Oct. 16, 2023

Liver diseases, characterized by high morbidity and mortality, represent a substantial medical problem globally. The current therapeutic approaches are mainly aimed at reducing symptoms slowing down the progression of diseases. Organ transplantation remains only effective treatment method in cases severe liver pathology. In this regard, development new stimulating regeneration, both activation organ’s own resources or different agents that trigger does not cease to be relevant. To date, many systematic reviews meta-analyses have been published confirming effectiveness mesenchymal stromal cell (MSC) diseases various severities etiologies. However, despite successful use MSCs clinical practice promising results animal models mechanisms their protective regenerative action remain poorly understood. Specifically, data about molecular produced these cells mediating fragmentary often contradictory. Since MSC-like found all tissues organs, it is likely key intercellular interactions within tissue niches dependent on MSCs. context, essential understand underlying communication between differentiated parenchymal each particular tissue. This important from perspective basic science for involving modulation activity resident With regard liver, research concentrated intercommunication hepatocytes under normal conditions during pathological process. goals review were identify factors crosstalk determine possible interaction two types stressful conditions. analysis hepatocyte–MSC showed carry out chaperone-like functions, including synthesis supportive extracellular matrix proteins; prevention apoptosis, pyroptosis, ferroptosis; support regeneration; elimination lipotoxicity ER stress; promotion antioxidant effects; donation mitochondria. suggest very close interdependence, even direct cytoplasm organelle exchange.

Language: Английский

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Research Progress of Chinese Medicine in Treating Chronic Liver Disease by Regulating Autophagy

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 29, 2024

In recent years, rising living standards and an accelerated lifestyle have led to increase in the incidence of chronic liver disease. Modern medicine has yet fully develop effective methods for preventing treating these conditions due their complex pathogenesis. Autophagy, a cellular process that maintains homeostasis by removing abnormal proteins, emerged as promising therapeutic target diseases. These diseases include fibrosis, cirrhosis, non-alcoholic steatohepatitis, hepatitis B, hepatocellular carcinoma. Chinese medicine, with its multi-component, multi-target, multi-pathway approach, offers unique advantages conditions, especially given unclear etiology Recent research demonstrates — comprising single herbs, herbal combinations, proprietary formulas can effectively regulate autophagy, thereby providing preventive benefits This paper reviews studies, categorizes various diseases, examines impact active ingredients compound from on autophagy. insights are crucial slowing progression pave way future application managing through autophagy modulation.

Language: Английский

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Mortality related to HCV and other chronic liver diseases in Veneto (Italy), 2008–2021: Changes in trends and age‐period‐cohort effects

Liver International, Journal Year: 2023, Volume and Issue: 44(2), P. 559 - 565

Published: Nov. 30, 2023

Abstract Background and Aims The objective of this study was to assess the impact COVID‐19 pandemic direct‐acting antiviral (DAA) agents on mortality related chronic liver diseases (CLD). Methods Age‐standardized rates were computed based CLD as underlying cause death (UCOD) any mention in certificates (multiple causes death‐MCOD). Time trends age‐standardized investigated using generalized estimation equation models. Additionally, we conducted age, period, birth cohort (APC) analyses CLD‐related associated with alcohol hepatitis C virus (HCV). Results Between 2008 2021, among residents Veneto region (Northeastern Italy) aged ≥35 years, there 20 409 deaths UCOD 30 069 MCOD from all CLD. We observed a 4% annual decline MCOD‐based throughout 2008–2021, minor peaks corresponding epidemic waves. Starting 2016, HCV‐related accelerated further ( p < .001). A peak 1963–1967 observed, which levelled off by end period. Mortality alcoholic disease declined at slower pace, becoming most common aetiology mentioned certificates. Conclusions demonstrates significant decrease population level Italy introduction DAAs. Continuous monitoring data is warranted determine if favourable trend will continue. Further studies utilizing additional health records are needed clarify role other etiologies.

Language: Английский

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COVID-19, Possible Hepatic Pathways and Alcohol Abuse—What Do We Know up to 2023?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2212 - 2212

Published: Feb. 12, 2024

The pandemic period due to coronavirus disease 2019 (COVID-19) revolutionized all possible areas of global health. Significant consequences were also related diverse extrapulmonary manifestations this pathology. liver was found be a relatively common organ, beyond the respiratory tract, affected by severe acute syndrome coronavirus-2 (SARS-CoV-2). Multiple studies revealed essential role chronic (CLD) in general outcome infection. Present concerns field are direct hepatic caused COVID-19 and pre-existing disorders as risk factors for course Which mechanism has key phenomenon—previously existing disorder or failure SARS-CoV-2—is still not fully clarified. Alcoholic (ALD) constitutes another elucidated context Should toxic effects ethanol already developed cirrhosis its perceived causative triggering factor impairment patients? In face these discrepancies, we decided summarize whole picture infection, paying special attention ALD focusing on pathological pathways COVID-19, toxicity cirrhosis.

Language: Английский

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Targeting Long Non-Coding RNA H19 as a Therapeutic Strategy for Liver Disease.

Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

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Outcomes of Pregnancy in Patients With Chronic Liver Disease

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Background and objectives Chronic liver disease (CLD), due to its increased prevalence, is a global public health concern. With improved care of CLD patients nowadays, more with cirrhosis or are getting pregnant. Pregnancy in the setting associated significant maternal fetal complications. The this study were determine outcomes pregnancy ascertain association between outcomes. Materials methods This retrospective was conducted at Gastroenterology Department Hayatabad Medical Complex, Peshawar, after approval from hospital's ethical committee. A total 91 pregnant included. Data these retrieved hospital information management system. Baseline parameters clinical participants recorded. Maternal noted. analyzed using IBM SPSS Statistics for Windows, Version 25 (Released 2017; Corp., Armonk, New York, United States). Inferential statistics, including univariate logistic regression analysis, used various factors influencing fetomaternal p-value ≤0.05 considered statistically significant. Results mean age 30.85±6.20 years, gestational 29.66±4.15 weeks, duration 27.65±9.481 months. Viral hepatitis most frequent etiology (62.6%). Fifty-four (59.3%) noted have fertility medications. Regarding outcomes, 13 (14.3%) had preterm labor, 47 (51.6%) cesarean section as mode delivery, post-partum hemorrhage (PPH) observed patients. In terms low birth weight 29 (31.9%) babies, intrauterine death (IUD) babies 27 (29.7%) Apgar scores birth. significantly delivery (p<0.001). Similarly, (p=0.049), body mass index (p=0.017), decompensated (p=0.030) high likelihood IUD. score (p=0.013). Conclusion an risk complications (preterm labor PPH) (IUD, weight, score). age, index,

Language: Английский

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Combination of melt-electrospun poly-ε-caprolactone scaffolds and hepatocyte-like cells from footprint-free hiPSCs to create 3D biohybrid constructs for liver tissue engineering

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 13, 2023

The liver is a vital organ with numerous functions, including metabolic detoxification, and the synthesis of secretory proteins. increasing prevalence diseases requires development effective treatments, models, regenerative approaches. field tissue engineering represents significant advance in overcoming these challenges. In this study, 3D biohybrid constructs were created by combining hepatocyte-like cells (HLCs) derived from patient-specific footprint-free human induced pluripotent stem (hiPSCs) melt-electrospun poly-ε-caprolactone (PCL) scaffolds. First, differentiation procedure was established to obtain autologous HCLs hiPSCs reprogrammed renal epithelial using self-replicating mRNA. obtained expressed hepatocyte-specific markers exhibited important hepatocyte such as albumin synthesis, cytochrome P450 activity, glycogen storage, indocyanine green metabolism. Biocompatible PCL scaffolds fabricated melt-electrospinning seeded pre-differentiated hepatoblasts, which uniformly attached fibers successfully matured into HLCs. use patient-specific, hiPSC-derived HLCs promising cell source for personalized regeneration strategies. combination biocompatible scaffolds, innovative approach has broader range applications spanning engineering, drug testing discovery, disease modeling.

Language: Английский

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