Unlocking the adenosine receptor mechanism of the tumour immune microenvironment

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: June 27, 2024

The suppressive tumour microenvironment significantly hinders the efficacy of immunotherapy in treating solid tumors. In this context, stromal cells, such as tumour-associated fibroblasts, undergo changes that include an increase number and function immunosuppressive cells. Adenosine, a factor promotes growth, is produced from ATP breakdown markedly elevated microenvironment. It acts through specific binding to adenosine receptors, with A2A A2B receptor being primary drivers immunosuppression. This paper presents roles various receptors different microenvironments. review focus on cells non-cellular components Additionally, we summarize discuss recent advances potential trends using antagonists combined immunotherapy.

Language: Английский

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PD-L1/PD-1 Expression in the Treatment of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders: An Overview of Reviews

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 126 - 126

Published: March 25, 2025

Objective: In this overview, we present compelling evidence from multiple systematic reviews and meta-analyses (SRMAs) examine the prognostic role of PD-L1/PD-1 axis, as well potential personalized treatment strategies targeting in patients with oral squamous cell carcinoma (OSCC) potentially malignant disorders (OPMDs). Methods: Six databases were searched to retrieve review meta-analysis studies. The population interest was OSCC OPMDs whom expression PD-L1 PD-1 had been investigated. At least one following outcomes reported, along at clinicopathological feature: overall survival, disease-free or disease-specific survival. All studies assessed for risk bias using AMSTAR 2 tool. Results: A total 195 found through initial search, after duplicate removal, 97 screened by title abstract. Finally, five fit our inclusion criteria included review. Conclusions: Based on two published reviews, study revealed a lack value improving survival cancer patients. However, it showed correlation specific features such sex, lymph node metastasis, HPV status.

Language: Английский

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The role of monoclonal antibodies in the treatment of pancreatic and colon cancers

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 389 - 412

Published: Jan. 1, 2025

Language: Английский

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Recent Insights and Applications of Nanocarriers-Based Drug Delivery Systems for Colonic Drug Delivery and Cancer Therapy: An Updated Review

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104646 - 104646

Published: Feb. 1, 2025

Language: Английский

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Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 186, P. 118014 - 118014

Published: March 31, 2025

Language: Английский

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Molecular and Immunological Mechanisms Associated with Diesel Exhaust Exposure

Targets, Journal Year: 2025, Volume and Issue: 3(2), P. 14 - 14

Published: April 21, 2025

Air pollution, particularly from vehicular emissions, has emerged as a critical environmental health concern, contributing to global estimated 7 million premature deaths annually. Diesel exhaust, major component of urban air contains fine particulate matter and gases that evade respiratory filtration, penetrating deep into the lungs triggering oxidative stress, inflammation, immune dysregulation. Epidemiological in vitro studies have linked diesel exhaust exposure diseases such asthma, chronic obstructive pulmonary disease, fibrosis, lung cancer, with immunological mechanisms playing central role. particles induce impair macrophage phagocytosis, skew T-cell polarization toward pro-inflammatory Th2 Th17 responses, exacerbating inflammation tissue damage. Despite these insights, significant gaps remain understanding precise immunomodulatory pathways long-term systemic effects exposure. While animal models provide valuable data, they often fail capture complexity human responses. Further research is needed elucidate underlying exhaust-induced dysregulation, vulnerable populations pre-existing conditions. This review focuses on summarizing current knowledge identifying are essential for developing targeted interventions policies mitigate adverse impacts improve outcomes globally.

Language: Английский

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Photo-activated microtubule targeting drugs: Advancing therapies for colorectal cancer

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(26), P. 3257 - 3260

Published: July 9, 2024

Over the years immunotherapy has demonstrably improved field of cancer treatment. However, achieving long-term survival for colorectal (CRC) patients remains a significant unmet need. Combination immunotherapies incorporating targeted drugs like MEK or multi-kinase inhibitors have offered some palliative benefit. Nevertheless, substantial gaps remain in current therapeutic armamentarium CRC. In recent years, there been surge interest exploring novel treatment strategies, including application light-activated conjunction with optical devices. This approach holds promise localized and delivery cytotoxic agents, such as microtubule-targeting drugs, directly to cancerous cells within colon.

Language: Английский

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Editor-in-Chief articles of choice and comments from January to June 2024

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(34), P. 3875 - 3882

Published: Sept. 8, 2024

As the Editor-in-Chief of

Language: Английский

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