Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125437 - 125437
Published: Dec. 1, 2024
Language: Английский
Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 120928 - 120928
Published: Jan. 1, 2025
Language: Английский
Citations
0
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 446 - 446
Published: Feb. 12, 2025
Background: Microplastics (MPs) are small plastic fragments with diameters less than 5 mm in size and prevalent everyday essentials consumables. Large global production has now led to a flooding of MPs our natural environment. Due their detrimental impacts on the planet's ecosystems potentially health, have emerged as significant public health concern. In this pilot study, we hypothesize that exposure will negatively affect gut microbiota composition function, which metabolic reprogramming plays an important role. Methods: Using vitro experiments, three bacterial strains (Escherichia coli MG1655, Nissle 1917, Lactobacillus rhamnosus) were selected investigate exposure. The individually cultured anaerobic chamber exposed 1 µm polystyrene at various concentrations (0, 10, 20, 50, 100, 500 µg/mL) culture medium. Results: reduced growth all dose-dependent manner. Liquid chromatography mass spectrometry (LC-MS)-based untargeted metabolomics revealed differences multiple pathways, such sulfur metabolism amino sugar nucleotide metabolism. addition, extracted from C57BL/6 mice, 16S rRNA sequencing results showed upregulation Lactobacillales reduction Erysipelotrichales due Furthermore, targeted corroborated alterations microbial tryptophan energy producing glycolysis/gluconeogenesis pentose phosphate pathway. Conclusions: These findings provide evidence causes comprehensive changes healthy microbiota, may also insights into mechanistic effects humans.
Language: Английский
Citations
0
Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(2), P. 39 - 39
Published: March 4, 2025
The plastic manufacturing industry has a crucial role in the global economy with significant impact wide range of fields. chemical risk to which workers are potentially exposed is difficult characterize and strictly related both products processes adopted. Among chemicals used, we can cite styrene, phenol, butadiene phthalates, but nano- microplastic particles also be released work environment. In this pilot study, present for first time an NMR-based metabolomic approach assessing urinary profiles employed company. Urine samples from twelve thirteen healthy volunteers were collected analyzed by NMR spectroscopy. Forty-six metabolites belonging different classes univocally identified quantified. dataset so obtained was then subjected multivariate statistical analysis each profile highlight any differences. An alteration some involved several pathways, such as amino acid metabolism NAD metabolism, found, strong on gut microflora speculated. Ultimately, our objective adding tile knowledge biological effects possibly occupational exposure even if it below threshold limit values.
Language: Английский
Citations
0
Published: April 4, 2025
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138225 - 138225
Published: April 1, 2025
Language: Английский
Citations
0
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 980, P. 179545 - 179545
Published: April 30, 2025
Micro- and nanoplastics (MNPLs) are emerging environmental pollutants that have garnered significant attention over the past few decades due to their detrimental effects on human health through various exposure pathways. This study investigates impact of MNPLs gut microbiota, utilizing Drosophila melanogaster as a model organism. was selected for its microbiota's similarities humans established role an accessible well-characterized system. To analyze full-length 16S rRNA gene sequencing performed using Nanopore platform, enabling comprehensive profiling microbial populations present in samples. As models MNPLs, two commercial polystyrene (PS-NPLs, 61.20 415.22 nm) one lab-made polylactic acid nanoplastic (PLA-NPLs, 463.90 were selected. positive control, zinc oxide nanoparticles (ZnO-NPs) used. The observed findings revealed induced notable alterations including reduction bacterial abundance shifts species composition. These results suggest can lead dysbiosis potential disruptions interaction, either with epithelial barrier or directly resident microorganisms.
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Nov. 25, 2024
Microplastics (MPs), defined as plastic particles smaller than 5 mm, are increasingly recognized environmental contaminants with potential health risks. These emerge breakdown products of larger plastics and omnipresent in marine, freshwater, terrestrial ecosystems. They primarily composed polymers such polyethylene, polypropylene, polystyrene, additives that enhance their performance. MPs also adsorb harmful chemicals like persistent organic pollutants heavy metals, posing risks to human health. Human exposure occurs mainly through ingestion inhalation, detected food products, water, even the air. have been shown accumulate gastrointestinal tract, disrupting gut microbiome, causing dysbiosis-a imbalance between beneficial bacteria. This disruption has linked various issues, including disorders, systemic inflammation, chronic diseases. Furthermore, gut-brain axis may be affected, neuroinflammatory consequences. As research continues unravel impacts MP exposure, understanding mechanisms accumulation broader implications on is crucial. review highlights effects health, emphasizing impact microbiome. We discuss connections cardiometabolic inflammatory diseases, disorders related Gut-Brain Axis. By synthesizing latest research, this work sheds light silent yet pervasive threat posed by underscores importance further studies understand fully.
Language: Английский
Citations
3
Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125437 - 125437
Published: Dec. 1, 2024
Language: Английский
Citations
0