Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3694 - 3694
Published: Nov. 1, 2024
: Adenocarcinomas of the esophagogastric junction and stomach present clinical entities with significant cancer-related morbidity mortality, often requiring multimodal treatments. Preoperative chemotherapy, mainly FLOT regimen, is increasingly being utilized in neoadjuvant setting for treatment these malignancies, varying degrees tumor response.
Language: Английский
Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 75 - 75
Published: Jan. 10, 2025
Recent developments in single-cell multi-omics technologies have provided the ability to identify diverse cell types and decipher key components of tumor microenvironment (TME), leading important advancements toward a much deeper understanding how heterogeneity contributes cancer progression therapeutic resistance. These are able integrate data from molecular genomic, transcriptomic, proteomics, metabolomics studies cells at resolution scale that give rise full cellular complexity TME. Understanding complex sometimes reciprocal relationships among cells, CAFs, immune ECs has led novel insights into their immense functions, which can consequences on behavior. In-depth uncovered evasion mechanisms, including exhaustion T metabolic reprogramming response hypoxia cells. Single-cell also revealed resistance such as stromal cell-secreted factors physical barriers extracellular matrix. Future examining specific pathways targeting approaches reduce TME will likely lead better outcomes with immunotherapies, drug delivery, etc., for treatments. incorporate data, spatial micro-environments, translation personalized therapies. This review emphasizes provide TME, revealing reprogramming, influences. aim guide development targeted therapies, highlighting role diversity shaping behavior treatment outcomes.
Language: Английский
Citations
6
Cells, Journal Year: 2025, Volume and Issue: 14(6), P. 403 - 403
Published: March 10, 2025
The tumor microenvironment is a dynamic and complex three-dimensional network comprising the extracellular matrix diverse non-cancerous cells, including fibroblasts, adipocytes, endothelial cells various immune (lymphocytes T B, NK dendritic monocytes/macrophages, myeloid-derived suppressor innate lymphoid cells). A constantly rapidly growing number of studies highlight critical role these in shaping cancer survival, metastatic potential therapy resistance. This review provides synthesis current knowledge on modulating cellular progression response to treatment.
Language: Английский
Citations
0
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: April 5, 2025
Abstract Gastrointestinal malignancies are responsible for approximately 35% of all cancer-related deaths, underscoring the critical need to explore pharmacologically active molecules chemoprevention. Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a natural compound derived from traditional Chinese and Japanese medicine, has recently garnered significant attention its potential anticancer properties. exerts chemoprotective effects through combination antioxidative, anti-inflammatory, anti-proliferative mechanisms. Research indicates that emodin inhibits cancer metastasis, disrupts cell cycle progression, impairs survival. These mediated activation p38 MAPK/JNK1/2 signaling pathway, upregulation pro-apoptotic factors such as Bax/Bcl-2 caspases, enhancement reactive oxygen species (ROS) levels (Supplementary Fig. 1). To optimize emodin’s therapeutic potential, it is crucial further investigate underlying mechanisms action develop advanced nano-targeted delivery systems enhance bioavailability. This review highlights promise chemopreventive agent gastrointestinal cancers emphasizes development into novel clinical formulation.
Language: Английский
Citations
0
World Journal of Experimental Medicine, Journal Year: 2024, Volume and Issue: 14(3)
Published: Aug. 28, 2024
Esophageal squamous cell carcinoma (ESCC) is a substantial global health burden. Immune escape mechanisms are important in ESCC progression, enabling cancer cells to the surveillance of host immune system. One key player this process Aryl Hydrocarbon Receptor (AhR), which influences multiple cellular processes, including proliferation, differentiation, metabolism, and regulation. Dysregulated AhR signaling participates development by stimulating carcinogenesis, epithelial-mesenchymal transition, escape. Targeting potential therapeutic approach for ESCC, with ligands showing efficacy preclinical studies. Additionally, modification combination therapies present new opportunities intervention. This review aims address knowledge gap related role pathogenesis
Language: Английский
Citations
1
Cancers, Journal Year: 2024, Volume and Issue: 16(21), P. 3694 - 3694
Published: Nov. 1, 2024
: Adenocarcinomas of the esophagogastric junction and stomach present clinical entities with significant cancer-related morbidity mortality, often requiring multimodal treatments. Preoperative chemotherapy, mainly FLOT regimen, is increasingly being utilized in neoadjuvant setting for treatment these malignancies, varying degrees tumor response.
Language: Английский
Citations
0