Efficacy and safety of low-dose tetracycline, amoxicillin quadruple therapy in Helicobacter pylori infection: A retrospective single center study DOI
Yiru Zhao, Xinjie Wang, Mengjia Zhu

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(39), P. 4295 - 4304

Published: Oct. 11, 2024

BACKGROUND Helicobacter pylori (H. ) eradication rates have declined with the rise of antibiotic-resistant strains in recent years. Although highly effective a low prevalence resistance, standard dose tetracycline is associated frequent adverse events. The efficacy and safety low-dose as part amoxicillin-containing bismuth quadruple therapy are not well described. AIM To compare compared to combined patients H. infection. METHODS Consecutive infection receiving tetracycline, amoxicillin, proton pump inhibitor, for 14 days at Sir Run Shaw Hospital (1/2022-6/2023) were evaluated. group received 500 mg twice daily (bid) while 750 bid or three times (tid). Primary endpoints rate treatment-related RESULTS mean age 218 was 48.7 ± 14.0 years, 120 (55%) male, 118 (54.1%) treatment primary therapy. Furthermore, 73 (33%) (500 bid) 145 (67%) including tid 74 71 (33%). On intention-to-treat analysis, 89% [95% confidence interval (CI): 82%-96%] group, 82% (95%CI: 74%-91%) 79% 69%-89%) without statistically significant difference (P = 0.25). incidence events lower (12.3% vs 31.1% 23.9%; P 0.02). CONCLUSION Low-dose amoxicillin achieved high fewer regimen

Language: Английский

Standardized Aqueous Extract of  Abutilon theophrasti Medic. Ameliorates Experimental Gastric Ulcer: A Bioinformatic and Pharmacological Study DOI
Hui Guo, Zihan Xu, Lili Zhu

et al.

Published: Jan. 1, 2025

Ethnopharmacological relevance: The herb Abutilon theophrasti Medic. (AT, Qingma in Chinese), a widely distributed medicinal plant various regions worldwide, is commonly used China for treating inflammatory diseases the gastrointestinal (GI) tract such as dysentery. However, pharmacological basis of this peptic ulcer, also an condition GI tract, remains insufficiently understood. Aim study: To investigate ameliorating effects and mechanism action standardized aqueous extract AT (ATAE) on experimental gastric ulcer (GU) rats using bioinformatic approaches.

Language: Английский

Citations

0
Helicobacter pylori infection and gastric microbiota: Insights into gastric and duodenal ulcer development DOI

Yan Pan,

Fuyong Jiao

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(7)

Published: Jan. 18, 2025

Helicobacter pylori (H. pylori) infection plays a critical role in gastric diseases, impacting the microbiota structure and duodenal ulcers. In their study, Jin et al utilized metagenomic sequencing to analyze mucosal samples from patients with ulcers healthy controls, revealing significant changes microbial diversity composition. This article reviews findings, emphasizing H. pylori's need for further research on its impact We evaluate study's strengths limitations, suggesting future directions enhance our understanding of contribution ulcerative diseases.

Language: Английский

Citations

0
ANÁLISE E ÓBITOS POR DECORRÊNCIA DE ÚLCERAS GÁSTRICAS NOS ÚLTIMOS DEZ ANOS (2014 – 2023) NO BRASIL DOI Creative Commons

Luana Barbosa Parente,

Emanuelly Bringel Batista Alencar,

Camila Alencar Ferreira Cavalcanti

et al.

Revista Contemporânea, Journal Year: 2024, Volume and Issue: 4(8), P. e5397 - e5397

Published: Aug. 12, 2024

O objetivo deste estudo foi analisar os óbitos decorrentes de úlceras gástricas no Brasil entre 2014 e 2023. Realizou-se um retrospectivo descritivo, utilizando dados secundários do DATASUS. Foram analisadas variáveis como sexo, faixa etária, raça/cor região geográfica. Os resultados mostraram 112.456 óbitos, com predominância masculina (65,27%). A etária mais afetada 50 a 59 anos (18,85%). Pessoas pardas representaram 35,65% dos óbitos. Sudeste apresentou o maior número seguida pelas regiões Nordeste Sul. discussão sugere que as disparidades regionais nos podem ser atribuídas diferenças acesso aos serviços saúde práticas uso medicamentos. alta mortalidade homens pode refletir exposição fatores risco tabagismo consumo álcool. As desigualdades também refletem qualidade saúde. É crucial investir em novas terapias vigilância epidemiológica para monitorar tendências eficácia das intervenções. Dados precisos atualizados são essenciais informar políticas pública estratégias clínicas visando redução da por Brasil.

Citations

0
Efficacy and safety of low-dose tetracycline, amoxicillin quadruple therapy in Helicobacter pylori infection: A retrospective single center study DOI
Yiru Zhao, Xinjie Wang, Mengjia Zhu

et al.

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(39), P. 4295 - 4304

Published: Oct. 11, 2024

BACKGROUND Helicobacter pylori (H. ) eradication rates have declined with the rise of antibiotic-resistant strains in recent years. Although highly effective a low prevalence resistance, standard dose tetracycline is associated frequent adverse events. The efficacy and safety low-dose as part amoxicillin-containing bismuth quadruple therapy are not well described. AIM To compare compared to combined patients H. infection. METHODS Consecutive infection receiving tetracycline, amoxicillin, proton pump inhibitor, for 14 days at Sir Run Shaw Hospital (1/2022-6/2023) were evaluated. group received 500 mg twice daily (bid) while 750 bid or three times (tid). Primary endpoints rate treatment-related RESULTS mean age 218 was 48.7 ± 14.0 years, 120 (55%) male, 118 (54.1%) treatment primary therapy. Furthermore, 73 (33%) (500 bid) 145 (67%) including tid 74 71 (33%). On intention-to-treat analysis, 89% [95% confidence interval (CI): 82%-96%] group, 82% (95%CI: 74%-91%) 79% 69%-89%) without statistically significant difference (P = 0.25). incidence events lower (12.3% vs 31.1% 23.9%; P 0.02). CONCLUSION Low-dose amoxicillin achieved high fewer regimen

Language: Английский

Citations

0