Herbal medicine as a potential treatment for non-alcoholic fatty liver disease

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(9)

Published: Feb. 18, 2025

Non-alcoholic fatty liver disease (NAFLD) has emerged as a global public health concern, affecting over one-quarter of the population. It is closely associated with prevalence obesity and metabolic syndrome. Current treatment options for NAFLD are limited often have side effects. Traditional Chinese medicine (TCM) offers promising alternative its holistic approach use multi-component herbal formulations. A recent study explored potential TCM formula, "Fanlian Huazhuo Formula (FLHZF)", to alleviate high-fat diet-induced by regulating autophagy lipid synthesis signaling pathways. shown advantages in prevention due efficacy minimal However, complex multicomponent multitarget characteristics formulas such FLHZF present challenges research. Future studies should focus on utilizing modern techniques deepen our understanding mechanisms action active ingredients medicines, thereby promoting their modernization.

Language: Английский

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Potential of traditional Chinese medicine in the treatment of nonalcoholic fatty liver disease: A promising future

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(43), P. 4597 - 4601

Published: Oct. 31, 2024

In this editorial, we provide insights into the publication by Niu et al featured in latest edition of World Journal Gastroenterology . Specifically, our focus was on exploring potential traditional Chinese medicine (TCM) treating nonalcoholic fatty liver disease (NAFLD) induced a high-fat diet through various mechanisms. NAFLD is common condition, affecting approximately 25% world's population. It closely linked to metabolic syndrome, insulin resistance, excessive body weight, and irregular lipid processing, leading fat accumulation liver, as well oxidative stress inflammation. While maintaining healthy active lifestyle are essential for managing NAFLD, treatment options limited due undefined pathogenesis lack specific medications. TCM, rooted practices, presents promising alternative its "syndrome differentiation treatment" principles, enhancing metabolism, reducing inflammation, addressing fibrosis. Certain herbs, such Poria cocos , Puaria lobata Salvia miltiorrhiza have shown significant efficacy deposition improving function. Due systematic research analysis mechanisms, TCM anticipated yield new approaches prevent treat increasing clinical application.

Language: Английский

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Fanlian Huazhuo Formula: A promising herbal preparation for metabolic liver disease

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(46), P. 4964 - 4968

Published: Nov. 19, 2024

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) has increased significantly in recent decades and is projected to increase further due the rising obesity rates. MASLD patients are at higher risk developing advanced diseases "cirrhosis hepatocellular carcinoma" as well liver- or cardiovascular-related mortality. Existing lipid-lowering therapies failed reduce mortality these patients. Therefore, there an urgent need for pharmacotherapies that can control even reverse this disease. Fanlian Huazhuo Formula (FLHZF) a combination herbal preparation, its various individual constituents regulate hepatic lipid metabolism, adipose tissue inflammation, gut microbiota. Despite, useful effects, limited information available on benefits diet-induced hepatosteatosis. In article, we discuss research findings recently published about therapeutic effects FLHZF suppressing development underlying mechanisms. Utilizing series

Language: Английский

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Gut microbiota in gastrointestinal diseases: Insights and therapeutic strategies

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(39), P. 4329 - 4332

Published: Oct. 11, 2024

Considering the bidirectional crosstalk along gut-liver axis, gut-derived microorganisms and metabolites can be released into liver, potentially leading to liver injury. In this editorial, we comment on several studies published in recent issue of World Journal Gastroenterology . We focus specifically roles gut microbiota selected gastrointestinal (GI) diseases that are prevalent, such as inflammatory bowel disease, metabolic dysfunction-associated steatotic hepatitis B virus-related portal hypertension. Over past few decades, findings from both preclinical clinical have indicated an association between compositional changes pathogenesis aforementioned GI disorders. However, elucidating mechanisms underlying host-microbiota interactions remain limited. The purpose editorial is summarize current provide insights regarding context-specific microbiota. Ultimately, discovery microbiome-based biomarkers may facilitate disease diagnosis development personalized medicine.

Language: Английский

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Fanlian Huazhuo formula: A promising therapeutic approach for metabolic associated steatotic liver disease

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 31(1)

Published: Dec. 9, 2024

This article reviews the study, “Fanlian huazhuo formula alleviates high-fat-diet-induced nonalcoholic fatty liver disease by modulating autophagy and lipid synthesis signaling pathway” published in World Journal of Gastroenterology . The study explores therapeutic potential Fanlian Huazhuo (FLHZF) treating metabolic-associated steatotic (MASLD), demonstrating that FLHZF reduces accumulation, oxidative stress, injury MASLD models key pathways involved metabolism autophagy. editorial emphasizes as a treatment for calls further research to verify its clinical efficacy.

Language: Английский

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