Factors influencing the incidence of early gastric cancer: a bayesian network analysis

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 21, 2025

This study aims to establish a Bayesian network risk prediction model for gastric cancer using data mining methods. It explores both direct and indirect factors influencing the incidence of reveals interrelationships among these factors. Data were collected from early screenings conducted at People's Hospital Lincang between 2022 2023. Initial variable selection was performed Least Absolute Shrinkage Selection Operator (Lasso) Sliding Windows Sequential Forward (SWSFS), screened variables demographic characteristics features used as constructing (BN) model. Subsequently, performance models evaluated, optimal selected mapping inference best The rate in this region's high-risk population determined be 7.09%. BN constructed set consisting Lasso's had better performance. A total 12 incorporated into form structure 13 nodes 18 edges. shows that age, gender, ethnicity, current address, upper gastrointestinal symptoms (nausea, acid reflux, vomiting), alcohol consumption, smoking, SGIM gastritis, family history are important development. provides an intuitive framework understanding contributing onset cancer, elucidating Furthermore, demonstrates satisfactory predictive performance, which may facilitate detection enhance levels diagnosis treatment populations.

Language: Английский

Controversy regarding the risk of autoimmune gastritis on gastric adenocarcinoma

Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Language: Английский

Streptococcus anginosus: the potential role in the progression of gastric cancer

Journal of Cancer Research and Clinical Oncology, Journal Year: 2025, Volume and Issue: 151(4)

Published: April 19, 2025

Gastric cancer (GC) is among the most common and aggressive malignancies worldwide, characterized by a poor prognosis. Research on its pathogenesis progression continues to evolve. Streptococcus anginosus (S. anginosus, SA) Gram-positive coccus commonly found in oral cavity upper respiratory tract, serving as commensal bacterium oral, gastrointestinal, genitourinary tracts. It frequently associated with abscess formation various organs tissues, well other purulent infections. In recent years, S. has gained increasing attention for role GC progression, potentially leading chronic gastric inflammation precancerous lesions, ultimately promoting development of GC. Emerging evidence indicates strong association between malignant unfavorable prognosis This review summarizes underlying mechanisms proposes that plays pivotal initiation underscoring potential therapeutic significance.

Language: Английский