Potential of Chlorogenic Acid in the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Animal Studies and Clinical Trials—A Narrative Review

Metabolites, Journal Year: 2024, Volume and Issue: 14(6), P. 346 - 346

Published: June 20, 2024

Chlorogenic acid (CGA) is a natural polyphenol found in coffee, tea, vegetables, and fruits. It exhibits strong antioxidant activity possesses several other biological properties, including anti-inflammatory effects, antimicrobial activity, insulin-sensitizing properties. Moreover, it may improve lipid glucose metabolism. This review summarizes the available information on therapeutic effect of CGA metabolic dysfunction-associated steatotic liver disease (MASLD). As literature search engine, browsers PubMed, Scopus, Web Science databases, ClinicalTrials.gov register were used. Animal trials clinical studies suggest that has promising potential treating MASLD hepatic steatosis. Its mechanisms action include antioxidant, anti-inflammatory, anti-apoptotic effects via activation Nrf2 signaling pathway inhibition TLR4/NF-κB cascade. Furthermore, alleviation by also involves important molecules such as AMPK physiological processes intestinal barrier gut microbiota. Nevertheless, specific target cell key molecule to which directed remain unidentified require further study.

Language: Английский

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Flaxseed-derived peptide, Ile-Pro-Pro-Phe (IPPF), ameliorates hepatic cholesterol metabolism to treat metabolic dysfunction-associated steatotic liver disease by promoting cholesterol conversion and excretion

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

IPPF ameliorates hepatic cholesterol metabolism to treat MASLD.

Language: Английский

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Hepatic-specific vitamin D receptor downregulation alleviates aging-related metabolic dysfunction-associated steatotic liver disease

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(14)

Published: April 9, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by the abnormal lipid deposition in hepatocytes. The prevalence of MASLD significantly increased elderly population, suggesting that aging may be related to occurrence MASLD. Emerging evidences suggest vitamin D receptor (VDR) implicated progression Therefore, additional researches are warranted elucidate whether VDR plays a role aging-related To investigate relationship between and explore mechanisms Cellular senescence models were established, phenotype telomerase RNA component knockout mice was validated. These then used as model for subsequent studies. Changes expression livers examined. knockdown models, including cell hepatic-specific mice, constructed, established these models. Additionally, (VD)-supplemented senescent lines constructed. steatosis cells more severe than normal (P < 0.05). Moreover, hepatic pronounced compared control group when successfully induced we concluded aggravated steatosis. after aging. alleviated When stimulated with VD, cellular However, VD supplementation had no effect on mice. Aging can lead steatosis, could serve potential molecular target

Language: Английский

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Quercetin: A Promising Candidate for the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5245 - 5245

Published: Nov. 6, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a chronic disease. The development of MASLD is influenced by multitude diseases associated with modern lifestyles, including but not limited to diabetes mellitus, hypertension, hyperlipidaemia and obesity. These conditions are often consequences the adoption unhealthy habits, namely sedentary lifestyle, lack physical activity, poor dietary choices excessive alcohol consumption. treatment primarily based on modifying patient's lifestyle pharmacological intervention. Despite absence FDA-approved agents for MASLD, several potential therapeutic modalities have demonstrated efficacy in reversing histopathological features Among botanical ingredients belonging flavonoid group quercetin (QE). QE has been possess number beneficial physiological effects, anti-inflammatory, anticancer antifungal properties. Additionally, it functions as natural antioxidant. Preclinical evidence indicates that may play role reducing damage improving metabolic health. Early human studies also suggest be an effective due its antioxidant, lipid-regulating This review aims summarize available information effects MASLD.

Language: Английский

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Use of Metabolic Scores and Lipid Ratios to Predict Metabolic Dysfunction-Associated Steatotic Liver Disease Onset in Patients with Inflammatory Bowel Diseases

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 2973 - 2973

Published: April 25, 2025

Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly recognized in inflammatory bowel (IBD) patients due to chronic inflammation and metabolic disturbances. However, reliable non-invasive biomarkers for MASLD prediction this population are lacking. This study evaluated the predictive value of scores lipid ratios onset IBD patients. Methods: An observational retrospective was conducted on 358 at “Renato Dulbecco” Teaching Hospital Catanzaro, Italy, a period between 1 January 2021 31 December 2024. Clinical laboratory data, including ratios, were analyzed using chi-square Kruskal–Wallis tests as appropriate. Post hoc comparisons Dunn’s test. Receiver operating characteristic analysis assessed their accuracy MASLD. p < 0.05 considered significant. Results: IBD-MASLD had significantly higher body mass index (BMI, 27 ± 4 vs. 22 2 kg/m2; 0.001), waist circumference (100 11 85 cm; other anthropometric parameters, scores, than IBD-only The score insulin resistance [METS-IR, area under curve (AUC = 0.754)] 0.754) exhibited highest accuracy, followed by accumulation product (LAP, AUC 0.737), BMI 0.709), triglyceride/high-density lipoprotein (TG/HDL, 0.701). Insulin homeostasis model assessment 0.680) triglyceride-glucose 0.674), moderate use. visceral adiposity 0.664) low-density lipoprotein/high-density 0.656) showed lower discriminative ability, while fibrosis-4 0.562) weakest diagnostic performance. Conclusions: Our findings suggest that primarily driven cardiometabolic dysfunction. introduction METS-IR, LAP, TG/HDL into clinical assessments could prove useful preventing cardiovascular complications setting.

Language: Английский

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Regular exercise suppresses steatosis‐associated liver cancer development by degrading E2F1 and c‐Myc via circadian gene upregulation

Genes to Cells, Journal Year: 2024, Volume and Issue: 29(11), P. 1012 - 1025

Published: Oct. 2, 2024

Abstract Regular exercise is believed to suppress cancer progression. However, the precise molecular mechanisms by which prevents development remain unclear. In this study, using a steatosis‐associated liver mouse model, we found that regular at speed of 18 m/min for 20 min daily suppressed development. To explore underlying mechanisms, examined gene expression profiles in livers and non‐exercise groups. The expressions circadian genes, such as Per1 Cry2, were upregulated group. As rhythm disruption known cause various diseases, including cancer, improving through could contribute prevention. We further series E2F1 c‐Myc target genes directly affect proliferation cells was downregulated transcriptionally unchanged but degraded post‐translational level exercise. regulated Skp1‐Cul1‐FBXL3 (SCF FBXL3 ) ubiquitin ligase complex binding FBXL3, can form with c‐Myc, think mechanism degrade them. Our study revealed previously unknown

Language: Английский

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Biological aging accelerates hepatic fibrosis: Insights from the NHANES 2017–2020 and genome-wide association study analysis.

Annals of Hepatology, Journal Year: 2024, Volume and Issue: 30(2), P. 101579 - 101579

Published: Oct. 18, 2024

Language: Английский

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