Biomarkers as Beacons: Illuminating Sepsis-Associated Hepato-Renal Injury DOI Open Access
M Pasare,

Cristian Sorin Prepeliuc,

M Grigoriu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4825 - 4825

Published: May 18, 2025

Sepsis, defined as a dysregulated host response to infection, is one of the leading causes mortality worldwide. It unleashes in organism cascade molecules, cytokines, and proteins which leads an inflammatory storm. If this infection uncontrolled, any organ susceptible damage. Acute kidney injury (AKI) most frequent dysfunctions septic patients, while it can be reversible, its presence higher burden morbidity mortality. While serum creatinine essential evaluating function, pathophysiology AKI not completely elucidated, plethora novel biomarkers have been studied hope early diagnosis fast treatment. liver affected by sepsis, plays important role guardian providing acute-phase proteins, activating neutrophils, controlling iron balance. failure (ALF) could impair organism’s capacity contain eliminate pathogens. Some molecules associated with either or ALF, although specific for dysfunction are difficult validate. The aim review understand several sepsis their clinical ability diagnosing predicting sepsis-induced hepato-renal dysfunction.

Language: Английский

Biomarkers as Beacons: Illuminating Sepsis-Associated Hepato-Renal Injury DOI Open Access
M Pasare,

Cristian Sorin Prepeliuc,

M Grigoriu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4825 - 4825

Published: May 18, 2025

Sepsis, defined as a dysregulated host response to infection, is one of the leading causes mortality worldwide. It unleashes in organism cascade molecules, cytokines, and proteins which leads an inflammatory storm. If this infection uncontrolled, any organ susceptible damage. Acute kidney injury (AKI) most frequent dysfunctions septic patients, while it can be reversible, its presence higher burden morbidity mortality. While serum creatinine essential evaluating function, pathophysiology AKI not completely elucidated, plethora novel biomarkers have been studied hope early diagnosis fast treatment. liver affected by sepsis, plays important role guardian providing acute-phase proteins, activating neutrophils, controlling iron balance. failure (ALF) could impair organism’s capacity contain eliminate pathogens. Some molecules associated with either or ALF, although specific for dysfunction are difficult validate. The aim review understand several sepsis their clinical ability diagnosing predicting sepsis-induced hepato-renal dysfunction.

Language: Английский

Citations

0