Asian Journal of Research in Chemistry,
Journal Year:
2022,
Volume and Issue:
unknown, P. 182 - 185
Published: April 9, 2022
In
this
review
we
explain
all
the
detailed
information
about
Microwave
assisted
synthesis.
Now
a
days
very
much
beneficial
in
to
synthesis
reaction
for
green
chemistry
work
by
various
reactions.
is
initially
used
save
energy
and
rate
of
fast.
capable
predicting
many
properties
fast
small
period
time
get
from
product.
type
chemical
also
done
microwave.
authors
words
on
their
subject
using
I
show
interest
into
microwave
because
performing
reaction.
principals
are
added
will
be
or
helpful
guide
scientist.
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(8), P. 5547 - 5565
Published: Jan. 1, 2024
Spiro
heterocycle
frameworks
are
a
class
of
organic
compounds
that
possesses
unique
structural
features
making
them
highly
sought-after
targets
in
drug
discovery
due
to
their
diverse
biological
and
pharmacological
activities.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(5), P. 3756 - 3828
Published: Jan. 1, 2025
Pyrazolo[1,5-
a
]pyrimidines
are
notable
class
of
heterocyclic
compounds
with
potent
protein
kinase
inhibitor
(PKI)
activity,
playing
critical
role
in
targeted
cancer
therapy.
Catalysts,
Journal Year:
2023,
Volume and Issue:
13(7), P. 1034 - 1034
Published: June 24, 2023
Multi-component
reactions
for
the
construction
of
heterocycles
have
been
fascinated
by
microwave
energy
as
an
alternative
technique
heating,
owing
to
advantages
over
traditional
reflux
methods.
The
heterogeneous
catalysts
contribute
significantly
towards
recycling,
harmless,
easy
filtration,
catalyst
preparation,
more
life
span,
abundance,
and
product
yields.
With
novel
creative
uses
in
organic
peptide
synthesis,
polymer
chemistry,
material
sciences,
nanotechnology,
biological
processes,
usage
has
rapidly
increased
during
past
20
years.
This
article
covers
multicomponent
involving
chromenes,
pyridines,
pyrroles,
triazoles,
pyrazoles,
tetrazoles,
trans
cis
julolidines
using
under
microwave.
It
provides
overview
contemporary
microwave-assisted
catalytic
reactions.
Microwave
chemistry
is
now
established
technology
with
several
regarding
reaction
rate
production
yield,
improving
savings
confirmed
many
applications.
Due
widespread
curiosity
medicinal
heterogeneously
catalysed
irradiation
explored
reduce
time
energy.
By
considering
various
aspects
economy,
eco-friendly,
user-friendly
factors,
this
review
focuses
on
recent
advances
multi-component
irradiation.
also
discusses
benefits
limitations
conditions
yields
from
literature
reports
five
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(24), P. 16091 - 16125
Published: Jan. 1, 2023
Pseudo-MCRs
are
domino-type
one-pot
processes
that
involve
combinations
of
at
least
three
reactants
(similarly
to
normal
MCRs)
but
in
which
one
them
is
stoichiometrically
duplicated
(or
more)
and
hence
takes
part
into
two
reaction
steps
more).
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
1308, P. 138104 - 138104
Published: March 21, 2024
In
an
attempt
towards
the
development
of
new
antimicrobials,
we
synthesized
by
microwave-assisted
multicomponent
reaction
(MCR)
enantiopure
(E,E)-3,5-bisarylidene-N-[(S)-(-)-methylbenzyl]-4-piperidones,
isatin
and
α-amino
esters
a
series
optically
active
tetracyclic
dispirooxindolopyrrolidine-piperidones.
The
beneficial
promising
features
this
protocol
such
as
simple
operational
procedure,
short
time
(10
min),
high
product
yields
(up
to
97%)
make
it
efficient
eco-friendly
approach
offering
powerful
mean
expand
structural
diversity
spirooxindoles.
This
appears
hugely
advantageous
for
high-throughput
screening
processes
in
drug
discovery
research.
addition,
crystallographic
parameters
inter-
intramolecular
interactions
occurring
spiropyrrolidine-fused
piperidone
derivative
4g
were
examined
through
single-crystal
XRD
analysis
allowing
determine
absolute
configuration
compound.
preliminary
biological
assessment
their
antimicrobial
activity
indicates
that
most
screened
products
display
higher
than
standard
reference
drugs
Ampicillin
Griseofulvin.
Some
them
exhibited
good
moderate
against
both
bacteria
fungi.
silico
molecular
docking
predictive
ADMET
studies
spirocompounds
carried
out.
Molecular
confirmed
binding
efficacy
candidates
4c
4l
low
score
energy
values
establishment
diverse
bonding
with
site
residues.
Finally,
profiling
spiroheterocycles
proved
remarkable
drug-like
pharmacokinetic
properties.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(9), P. 7103 - 7110
Published: Jan. 1, 2025
A
very
convenient
one-pot
method
for
the
synthesis
of
new
biologically
active
compounds,
spiro-4H-pyran
derivatives,
has
been
developed.
This
approach,
enables
incorporation
three
pharmacophoric
cores:
pyran,
pyridine
and
triazine
scaffolds,
within
a
single
molecular
skeleton
using
an
efficient
sequential
multicomponent
reaction.
The
starting
materials
include
ninhydrin,
cyanoacetohydrazide,
ethyl
cyanoacetate,
aromatic
aldehydes,
pyrazolone
malononitrile.
In
this
process,
spiropyran
derivatives
were
produced
with
high
efficiency
through
consecutive
reactions.
first
step
involves
1,6-diaminopyridinone
via
three-component
approach
readily
available
materials.
second
step,
pyridotriazine,
occurs
in
domino
way
without
need
to
separate
intermediate
product
step.
Finally,
third
offers
several
advantages,
including
fast
simple
purification
products,
use
safe
solvents,
no
metallic
toxic
catalysts,
atomic
economy
excellent
chemoselectivity
Beilstein Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
21, P. 564 - 595
Published: March 13, 2025
Formaldehyde
emerges
as
a
cornerstone
in
multicomponent
reactions,
mainly
prized
for
its
robust
reactivity.
Yet,
alongside
these
beneficial
traits,
this
highly
reactive
C1-building
block
raises
concerns,
primarily
regarding
toxicity.
One
notable
issue
is
the
challenge
of
controlling
formation
undesired
byproducts
during
reactions.
This
review
explores
alternative
blocks
that
serve
surrogates
formaldehyde,
aiming
to
mitigate
some
challenges
associated
with
use
By
identifying
alternatives,
toxicity
concerns
and
improved
reaction
control
can
be
addressed,
paving
way
more
efficient
sustainable
synthetic
methodologies.
