Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress

Molecules, Journal Year: 2022, Volume and Issue: 27(11), P. 3576 - 3576

Published: June 2, 2022

With increasing demand for customized commodities and the greater insight understanding of olfaction, synthesis fragrances with diverse structures odor characters has become a core task. Recent progress in organic catalysis enables rapid construction carbocycles heterocycles from readily available unsaturated molecular building blocks, increased selectivity, atom economy, sustainability product diversity. In this review, synthetic methods creating cyclic fragrances, including both natural ones, will be discussed, focus on key transformations alkenes, alkynes, dienes enynes. Several strategies cycloaddition, catalytic cyclization, ring-closing metathesis, intramolecular addition, rearrangement reactions. Representative examples featured olfactory investigations highlighted, along some perspectives future developments area.

Language: Английский

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Rapid gas–liquid reaction in flow. Continuous synthesis and production of cyclohexene oxide

Beilstein Journal of Organic Chemistry, Journal Year: 2022, Volume and Issue: 18, P. 660 - 668

Published: June 13, 2022

The enhanced reaction rate in the epoxidation of cyclohexene with air as an oxidant was discovered without any added catalyst utilizing a continuous flow reactor constructed readily available stainless steel parts and devices. This continuous-flow process demonstrates significant improvement time for highly selective epoxide production over batch due to efficient mass transfer between liquid phase air. operated continuously good operational stability, evaluated by constant high yield oxide, obtain desired product productivity.

Language: Английский

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Continuous‐Flow Synthesis of β‐Ketoesters and Successive Reactions in One‐Flow using Heterogeneous Catalysis

Advanced Synthesis & Catalysis, Journal Year: 2022, Volume and Issue: 364(19), P. 3389 - 3395

Published: Aug. 16, 2022

Abstract A continuous‐flow procedure for the synthesis of β‐ketoesters has been developed through Roskamp reaction between aldehydes and diazoesters in presence a Sn‐MCM‐41 catalyst. The viability this methodology was confirmed with range aromatic aliphatic provided good to excellent yields. Catalyst activity tested over three days (84 hours) operation, yield desired β‐ketoester maintained 73 89%. prepared were smoothly transformed into coumarin derivatives 5‐pyrazolone condensation reactions sequential flow. magnified image

Language: Английский

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What enables and blocks synthetic chemistry methods in becoming industrially significant?

Cell Reports Physical Science, Journal Year: 2023, Volume and Issue: 4(7), P. 101493 - 101493

Published: July 1, 2023

What factors will play a role in the decision process when looking at reasons for certain reactions being adopted large-scale industrial applications? An examination reveals that there are several parameters have power to be influential this regard, either on their own or combination, all dependent circumstances. Seen from pharmaceutical manufacturing point of view, only structural motifs interest in-depth investigations and, hence, demand synthetic methodologies allowing preparation quantities beyond what sensibly is achieved by ordinary laboratory procedures. This inevitably leads many and even reaction types fall wayside. A further criterion fulfill given synthesis must perform robust consistent manner, irrespective scale. Many methods used demanding but can handled controlled scientists well-versed art organic synthesis. On scale-up, such could behave capricious way, example under influence issues with heat transfer stirring efficiency, sensitivity trace amounts water, exposed non-inert atmosphere, which lead various levels problems complete failure. Another significant aspect key performance indicator medicinal chemistry capability make novel chemical compounds amenable patent protection. "race" into unknown discovery development unprecedented methodologies, eventually prove capabilities larger Finally, times where green sustainability top-rated criteria any process, bound major reluctance apply procedures cannot guarantee highest level environmental concern both ethical legal reasons.

Language: Английский

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Development of an amine transaminase-lipase cascade for chiral amide synthesis under flow conditions

Green Chemistry, Journal Year: 2023, Volume and Issue: 25(15), P. 6041 - 6050

Published: Jan. 1, 2023

An amine transaminase and a lipase have been immobilised in separated reactors containing EziG polymer-coated controlled porosity glass carrier materials to transform 1-phenoxypropan-2-one into the corresponding ( R )-acetamide organic solvent.

Language: Английский

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