Iodine(III)-Containing Reagents in Photo-Assisted and Photo-Catalyzed Organic Synthesis

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 784 - 784

Published: Feb. 8, 2025

Iodine(III) reagents have become a highly relevant tool in organic synthesis due to their great versatility as strong but green oxidants. Several transformations involving cyclizations well functionalization of different cores been broadly described and reviewed. Herein, the participation these photochemical exclusively by direct irradition or photoredox cycles using some transition metals, will be briefly plausible further that potentially can developed.

Language: Английский

Synthesis and Biological Evaluation of Strong Cytotoxic Maleimide Derivatives with Potential Multidrug Resistance Reversal Activity in the Breast Cancer Therapy

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(13)

Published: April 1, 2025

Abstract Maleimide core is a broadly used chemical‐based scaffold for natural and new compounds synthesis. Several of them show anticancer multidrug resistance (MDR) reversal activity. A family twelve 3,4‐substituted N ‐benzyl ‐methyl maleimides were synthesized in two‐step sequence consisting bromination Suzuki cross‐coupling or bromination–thiolation. We able to obtain two groups maleimide derivatives which tested determining their cytotoxicity. Following our previous work, the biological activity these as MDR agents was with cancerous cell line MCF‐7 that has been exposed chronically etoposide achieve MDR. resistant (MCF‐7R), treated combination synthetized compounds. The results presented strong effects 20 , 21 22 23 24, 25 no cells, IC 50 values proliferation inhibition ranged from 1.8–30.8 µM. between shows increase most except compound 15 where it shown low reversion degree. These findings suggest this work can be tumorigenic cancer cells before after acquiring resistance. should evaluated considering an undesirable effect caused due increase.

Language: Английский

Iodine(III) Reagents for the Aromatic Functionalization with Inorganic Groups

Tetrahedron, Journal Year: 2024, Volume and Issue: 166, P. 134203 - 134203

Published: Aug. 28, 2024

Language: Английский