Cu‐Catalyzed Reaction of Trifluoromethylated β‐Keto Diazos and Nitriles Proceeding via H2O Addition to Nitrile Ylides DOI
Haibo Mei,

Youlong Du,

Qian Wang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(16), P. 3443 - 3449

Published: May 22, 2024

Abstract A Cu‐catalyzed multi‐component reaction of trifluoromethylated β‐amino ketones and nitriles using tert ‐butyl nitrite as a diazotization reagent has been developed. Under the optimized conditions, N ‐trifluoroalkyl amides were obtained with yields up to 87%. Control experiments computational studies reveal that proceeds through generation diazo, in situ formation nitrile ylide, water addition final enol tautomerism. This approach features mild wide substrate tolerance, scale‐up applicability, which provides an efficient practical strategy for amide synthesis.

Language: Английский

Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles DOI Creative Commons
Ramin Javahershenas, Ata Makarem, Karel D. Klika

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(8), P. 5547 - 5565

Published: Jan. 1, 2024

Spiro heterocycle frameworks are a class of organic compounds that possesses unique structural features making them highly sought-after targets in drug discovery due to their diverse biological and pharmacological activities.

Language: Английский

Citations

26
Copper Catalyzed Formation of Carbon–Silicon Bond: A Review DOI
Rafid Jihad Albadr,

Waam Mohammed Taher,

Mariem Alwan

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

4
Recent achievements in synthesis of anthracene scaffolds catalyzed transition metals DOI Creative Commons
Fadhil Faez Sead, Vicky Jain,

R. Roopashree

et al.

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: March 3, 2025

In the last 10 years, synthesis of anthracene scaffolds has attracted considerable interest because their distinctive electronic characteristics and various uses in organic electronics, photovoltaics, therapeutics. Anthracene, a polycyclic aromatic hydrocarbon, is valued for its lightweight, stability, electron transport capabilities, making it key building block advanced materials. Traditional methods often face challenges such as low selectivity harsh conditions. However, recent advancements transition metal-catalyzed reactions have transformed field, offering more efficient versatile approaches. This review examines methodologies utilizing metal catalysts like palladium, zinc, indium, cobalt, gold, iridium, rhodium ruthenium, which enabled novel synthetic pathways selective formation substituted anthracenes through cross-coupling reactions. The function ligands, including phosphines N-heterocyclic carbenes, improving reaction efficiency also examined. shift towards greener noted, with focus on minimizing waste reducing toxic reagents. Several case studies demonstrate successful application these techniques, highlighting structural diversity functional potential derivatives applications.

Language: Английский

Citations

3
Transition‐Metal‐Catalyzed Reactions Involving Trifluoro Diazo Compounds and Their Surrogates DOI
Yeming Wang, Chaoqun Zhang,

Shizhe Li

et al.

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(27)

Published: May 22, 2024

Abstract Fluorinated organic compounds represent an important and growing family of active ingredients in various fields, including material science, pharmaceutical chemistry biological science. Developing efficient synthetic methods toward fluorinated have attracted much attention. In recent years, transition‐metal catalyzed reaction trifluoro diazo were a powerful convenient approach to afford trifluoromethyl‐ difluoromethyl‐substituted value. this review, the progress on transition‐metal‐catalyzed reactions involving their surrogates via trifluoromethylated carbene complex is described sequence 2,2,2‐trifluorodiazoethane as precursor, ethyl 3‐trifluoro‐2‐diazo‐propionate trifluoroethylamine hydrochloride or amines CF 3 CHN 2 surrogate well aldehydes/ketones N‐sulfonylhydrazones surrogate.

Language: Английский

Citations

3
Cu‐Catalyzed Reaction of Trifluoromethylated β‐Keto Diazos and Nitriles Proceeding via H2O Addition to Nitrile Ylides DOI
Haibo Mei,

Youlong Du,

Qian Wang

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(16), P. 3443 - 3449

Published: May 22, 2024

Abstract A Cu‐catalyzed multi‐component reaction of trifluoromethylated β‐amino ketones and nitriles using tert ‐butyl nitrite as a diazotization reagent has been developed. Under the optimized conditions, N ‐trifluoroalkyl amides were obtained with yields up to 87%. Control experiments computational studies reveal that proceeds through generation diazo, in situ formation nitrile ylide, water addition final enol tautomerism. This approach features mild wide substrate tolerance, scale‐up applicability, which provides an efficient practical strategy for amide synthesis.

Language: Английский

Citations

0