Macranthoidin B restrains the epithelial-mesenchymal transition through COX-2/PGE2 pathway in endometriosis DOI Creative Commons
Yi Ding, Xiaoqian Yang,

Qinghua Wei

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Introduction Macranthoidin B is one of the primary and unique triterpenoid saponin metabolites from Lonicera macranthoides Hand. –Mazz, which used to treat endometriosis (EMS) in traditional Chinese medicine. However, effect macranthoidin remains unknown EMS. This study aimed elucidate mechanism Methods Using rat autograft EMS model, volume ectopic endothelium, histopathology, serum E 2 PROG were evaluated after B’s treatment. In endometriotic stromal HEC1-B cells, invasion metastasis assessed by scratch wound Transwell tests. The epithelial-mesenchymal transition COX-2/PGE pathway examined vivo vitro . combined with LPS or celecoxib. Results a suppressed lesion volume, improved histopathological morphology, regulated estradiol (E2) progesterone (PROG) levels. Additionally, inhibited cells cells. Mechanistically, both LPS, COX-2/PGE2 activator, showed promotion transition, metastasis. exhibited antagonistic effects against LPS. Celecoxib, inhibitor, restrained celecoxib was enhanced B. Discussion prevents through It will facilitate development broaden its potential application.

Language: Английский

The role and clinical significance of tumor-associated macrophages in the epithelial–mesenchymal transition of lung cancer DOI Creative Commons

Liao Lei,

Yingxia Wang,

Susu Fan

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: April 15, 2025

Lung cancer remains the leading cause of cancer-related mortality worldwide. Tumor-associated macrophages (TAMs) and epithelial-mesenchymal transition (EMT) are key drivers lung metastasis drug resistance. M2-polarized TAMs dominate immunosuppressive tumor microenvironment (TME) promote EMT through cytokines such as TGF-β, IL-6, CCL2. Conversely, EMT-transformed cells reinforce TAM recruitment M2 polarization immunomodulatory factors CCL2 ZEB1, thereby establishing a bidirectional interplay that fuels progression. Current evidence on this interaction fragmented, comprehensive review TAM-EMT regulatory network its therapeutic implications is lacking. This systematically integrates mechanisms between EMT, highlighting their roles in It also summarizes emerging strategies targeting process, emphasizing potential for clinical translation. study fills gap systematic reviews providing theoretical foundation future research development novel therapies.

Language: Английский

Citations

0
Targeting oxygenases could be a viable anti-metastatic approach in cancer therapy DOI
Pengfei Shi, Jie Xu,

Hongjuan Cui

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143375 - 143375

Published: April 1, 2025

Language: Английский

Citations

0
Macranthoidin B restrains the epithelial-mesenchymal transition through COX-2/PGE2 pathway in endometriosis DOI Creative Commons
Yi Ding, Xiaoqian Yang,

Qinghua Wei

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Introduction Macranthoidin B is one of the primary and unique triterpenoid saponin metabolites from Lonicera macranthoides Hand. –Mazz, which used to treat endometriosis (EMS) in traditional Chinese medicine. However, effect macranthoidin remains unknown EMS. This study aimed elucidate mechanism Methods Using rat autograft EMS model, volume ectopic endothelium, histopathology, serum E 2 PROG were evaluated after B’s treatment. In endometriotic stromal HEC1-B cells, invasion metastasis assessed by scratch wound Transwell tests. The epithelial-mesenchymal transition COX-2/PGE pathway examined vivo vitro . combined with LPS or celecoxib. Results a suppressed lesion volume, improved histopathological morphology, regulated estradiol (E2) progesterone (PROG) levels. Additionally, inhibited cells cells. Mechanistically, both LPS, COX-2/PGE2 activator, showed promotion transition, metastasis. exhibited antagonistic effects against LPS. Celecoxib, inhibitor, restrained celecoxib was enhanced B. Discussion prevents through It will facilitate development broaden its potential application.

Language: Английский

Citations

0