METTL Family in Healthy and Disease

Molecular Biomedicine, Journal Year: 2024, Volume and Issue: 5(1)

Published: Aug. 19, 2024

Abstract Transcription, RNA splicing, translation, and post-translational protein modification are fundamental processes of gene expression. Epigenetic modifications, such as DNA methylation, play a crucial role in regulating The methyltransferase-like (METTL) family, constituent the 7-β-strand (7BS) methyltransferase subfamily, is broadly distributed across cell nucleus, cytoplasm, mitochondria. Members METTL through their S-adenosyl methionine (SAM) binding domain, can transfer methyl groups to DNA, RNA, or proteins, thereby impacting replication, transcription, mRNA participate maintenance normal function promote disease development. This review primarily examines involvement family differentiation, mitochondrial function, its association with tumor formation, nervous system, cardiovascular diseases. Notably, intricately linked cellular particularly regulation translation factors. represent important molecules development associated patient immunity tolerance radiotherapy chemotherapy. Moreover, future research directions could include drugs antibodies targeting structural domains, utilizing nanomaterials carry miRNA corresponding mRNA. Additionally, precise mechanisms underlying interactions between factors remain be clarified.

Language: Английский

RNA m6A Methylation and Alzheimer's Disease: Current Evidence and Future Perspectives

Human Brain, Journal Year: 2024, Volume and Issue: 3(1)

Published: March 15, 2024

Background: Alzheimer’s disease (AD) is the most common neurodegenerative characterized by pathological accumulation of b-amyloid and neurofibrillary tangles. Despite substantial progress in both basic clinical research on AD, detailed mechanism AD pathogenesis still elusive. RNA N6-methyladenosine methylation (m6A) predominant post-transcriptional modification eukaryotic mRNA, prominently enriched mammalian brain. Notably, m6A-modified showed significant changes during development indicating an important role this pathogenesis. Aim: In study, we aim to provide a summary recent advances highlighting indispensable m6A Result: From perspective modification, review our current understanding association between machinery risk factors as well its involvement various pathophysiological hallmarks AD. We also discuss main obstacles studies about corresponding caveats solutions them. Conclusion: This emphasizes significance investigating context highlights considerable potential for emerge novel therapeutic target

Language: Английский