Exploring HTRA1-Autosomal Dominant Disease: Literature Review of Clinical Features and Molecular Mechanisms DOI Creative Commons
Yijuan Li, Yi‐Cheng Zhu, Ming Yao

et al.

Human Brain, Journal Year: 2023, Volume and Issue: 2(2)

Published: May 20, 2023

Heterozygous HTRA1-autosomal dominant disease is a gradually recognized hereditary cerebral small vessel (cSVD) characterized by debilitating conditions and extensive white matter hyperintensities (WMHs), but doubts remain on the underlying mechanisms of this disease. This review summarizes clinical, MRI, molecular genetics features heterozygous in combination with two better-studied cSVDs. A total 31 mutations cases documented between 2020 2023 were also reviewed, characterizing mutation clinical manifestations. aims to gain better insight into unique characteristics its correlations other

Language: Английский

Alzheimer’s Disease Detection Using Deep Learning on Neuroimaging: A Systematic Review DOI Creative Commons
Mohammed Alsubaie, Suhuai Luo, Kamran Shaukat

et al.

Machine Learning and Knowledge Extraction, Journal Year: 2024, Volume and Issue: 6(1), P. 464 - 505

Published: Feb. 21, 2024

Alzheimer’s disease (AD) is a pressing global issue, demanding effective diagnostic approaches. This systematic review surveys the recent literature (2018 onwards) to illuminate current landscape of AD detection via deep learning. Focusing on neuroimaging, this study explores single- and multi-modality investigations, delving into biomarkers, features, preprocessing techniques. Various models, including convolutional neural networks (CNNs), recurrent (RNNs), generative are evaluated for their performance. Challenges such as limited datasets training procedures persist. Emphasis placed need differentiate from similar brain patterns, necessitating discriminative feature representations. highlights learning’s potential limitations in detection, underscoring dataset importance. Future directions involve benchmark platform development streamlined comparisons. In conclusion, while learning holds promise accurate refining models methods crucial tackle challenges enhance precision.

Language: Английский

Citations

38
Cultural adaptation and psychometric evaluation of the fear and avoidance of memory loss scale in a Chinese context DOI
Huohuo Dai, Chao Sun,

Shuyi Xu

et al.

Aging & Mental Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: Jan. 17, 2025

To cross-culturally adapt the Fear and Avoidance of Memory Loss (FAM) scale assess psychometric properties in Chinese cultural context. Following Beaton's guidelines, FAM was translated adapted. A cross-sectional study assessed its properties, including internal consistency (coefficient omega, Cronbach's alpha), test-retest reliability (intraclass correlation coefficients), criterion content validity. Construct validity through exploratory factor analysis (EFA) using principal axis factoring with direct oblimin rotation, optimal number factors determined by Kaiser parallel analysis. The version showed satisfactory consistency, reliability, EFA revealed a two-factor solution scale, leading to refined 17-item after excluding item 15 for low loading. adapted can be used as reliable effective tool evaluate fear avoidance specific memory loss among middle-aged older adults. removal suggests potential influences on coping mechanisms behaviors, indicating need further research.

Language: Английский

Citations

1
2023 China Alzheimer’s disease: facts and figures DOI Creative Commons

Jinwen Xiao,

Jianping Li, Jintao Wang

et al.

Human Brain, Journal Year: 2023, Volume and Issue: 2(3)

Published: Dec. 7, 2023

In China, the aging population and increasing incidence of Alzheimer's disease (AD) other dementias have emerged as major medical concerns. Extensive research new technologies on AD provided possibilities for early intervention, including emerging biomarkers detection drugs with disease-modifying therapy. This report includes a large amount facts figures to describe understanding patients their families about disease, discuss problems they encounter in current environment, outline potential difficulties clinical diagnosis treatment status. Furthermore, people’s concerns, overall effect caregivers, development are presented this report. Overall, increase public awareness suggests detection, screening, intervention while calling all sectors work together help patients.

Language: Английский

Citations

16
A comprehensive view of the molecular features within the serum and serum EV of Alzheimer's disease DOI
Jiayi Zhang, Xiaoqin Cheng, Anqi Hu

et al.

The Analyst, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

By harnessing the unique properties of both serum and EVs, we offer a comprehensive molecular insight into AD pathology, paving way for development non-invasive biomarkers diagnosis.

Language: Английский

Citations

0
Exploring the Mechanism by Which Zexie Tang Regulates Alzheimer's Disease: Insights from Multi-Omics Analysis DOI
Shijie Su, Kongli Huang, Han Cai

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 139, P. 156453 - 156453

Published: Feb. 7, 2025

Language: Английский

Citations

0
Factors associated with dementia risk reduction lifestyle in mild cognitive impairment: a cross-sectional study of individuals and their family caregivers DOI Creative Commons
Hong Chen,

Yongmei Deng,

Xuan Li

et al.

BMC Neurology, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 17, 2025

A healthy lifestyle has been shown to mitigate cognitive decline in patients with mild impairment, family caregivers playing a pivotal role the patients' management. Exploring level of dementia risk reduction and influencing factors at both patient caregiver levels impairment is crucial for identifying strategies improve lifestyles delay disease progression. Using convenience sampling method, 302 their admitted neurology departments four tertiary care hospitals China, from December 2024 February 2025 were recruited surveyed using general information questionnaire, Dementia Risk Reduction Lifestyle Scale (DRRLS), Motivation Change Health Behaviors scale (MCLHB-DRR), Perceived Social Support (PSSS), Mutuality (MS). Multiple linear regression was used analyze patients. DRRLS score 83.61 ± 16.13, multiple showed that patient's monthly individual income, presence chronic disease, health beliefs, social support independent influences on lifestyle. Furthermore, mutuality also The final model explained 75.5% variance Patients have characteristics collectively influence Healthcare providers should conduct early dyadic assessments develop targeted intervention based help them

Language: Английский

Citations

0
Patterns and trends in the burden of Alzheimer’s disease and related dementias in China (1990–2021) and predictions to 2040 DOI

Hui Min Chen,

Kuo Shen,

Ling Ji

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Background The epidemiology of Alzheimer's disease and related dementias (ADRD) in China is understudied as compared to global levels. Objective aim this study was examine the trend dementia from 1990 2021 provide predictions for next two decades. Methods Global Burden Disease (GBD) were used analyze prevalence, incidence, mortality, disability-adjusted life years (DALYs) rates due ADRD globally. Joinpoint regression analysis epidemiological trends 2021. A forecast prevalence conducted utilizing Autoregressive Integrated Moving Average (ARIMA) models. Results experiencing a growing burden ADRD. As 2021, number people with had risen 56.85 million (95%CI: 49.38, 64.98), up 21.80 19.07, 24.84) 1990. DALY all indicated greater among Chinese population levels, significantly higher female group. projected rate expected increase by 60% current rate. Conclusions continues age, presents an undeniable challenge. To mitigate improve overall health population, it essential establish comprehensive plan that focuses on increasing public awareness enhancing quality all, special attention given women.

Language: Английский

Citations

0
Colorimetric detection of amyloid-β oligomers using aptamer-templated DNA-Ag/Pt nanoclusters with peroxidase-like activity DOI

Chun Zheng,

Lushan Huang,

Ziyang Shen

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113740 - 113740

Published: April 1, 2025

Language: Английский

Citations

0
Disparities in lifestyle among community-dwelling older adults with or without mild cognitive impairment: a population-based study in north-western China DOI Creative Commons
Juxia Zhang, Jiarui Liu,

Yuping Feng

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 8, 2025

Evidences indicate that patients with unhealthy lifestyles are at a higher risk of cognitive impairment and dementia. However, uncertainty remains about the association mild (MCI) in less-developed areas. We used multi-stage stratified sampling method to obtain study population aged ≥65 years, subsequently cross-sectional survey was produced including 509 individuals (109 MCI 400 healthy controls) between March June 2023. A lifestyle score defined by scoring six behaviors (non-smoking, non-drinking, exercising, sleeping duration more than 6 h, having high-quality diet, controlled BMI). The function assessed using Mini-Mental State Examination (MMSE). mean age 73.8 57.6% were men participates, 21.4% have MCI. Subjects had significantly lower total MMSE, compared non-MCI subjects. Multivariate logistic regression analysis showed (smoking, drinking, non-compliance harmful sleep, physical inactivity, BMI) significant factors for presence MCI, independent as sex, age, education level, family history AD. prevalence is high, an factor area. Highlighting importance changes which may influence abilities older adults, specially settings approximate conditions.

Language: Английский

Citations

0
Curcumin's multi-target mechanisms in the treatment of Alzheimer's disease and creative modification techniques DOI

Xiqi Meng,

Gong Yong,

F Xiao

et al.

Journal of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Alzheimer's disease (AD) is a well-established neurodegenerative disorder characterized by memory impairment, cognitive dysfunction, and behavioral disturbances. With the global population aging, prevalence of AD continues to rise, presenting significant challenges both society healthcare systems. Curcumin, polyphenolic compound derived from turmeric rhizomes, has demonstrated considerable potential in treatment due its anti-inflammatory, antioxidant, neuroprotective properties. However, clinical application remains constrained chemical instability, poor water solubility, rapid metabolism, accelerated elimination. To overcome these limitations, various curcumin derivatives have been synthesized, combination therapy strategies explored. This review examines mechanisms through which may exert therapeutic effects AD, including inhibition neuroinflammation, regulation tau protein hyperphosphorylation, modulation amyloid-β peptides, provision antioxidant benefits. Additionally, advantages approaches are discussed, offering novel perspectives promising for treatment. It anticipated that advancements drug design will contribute development more effective options AD.

Language: Английский

Citations

0