Regional- and cell type-specific changes of the human brain during aging DOI Creative Commons
Yanxi Chen,

Gaoyu Zu,

Bill Ling Feng Zhang

et al.

Human Brain, Journal Year: 2024, Volume and Issue: 2(3)

Published: Jan. 10, 2024

As individuals age, cognitive decline becomes more prominent, concomitant with an elevated susceptibility to neurodegenerative diseases and dementia. Additionally, symptoms of chronic neuropsychiatric tend worsen age. It is crucial highlight that the aging process does not affect uniformly, its effects can vary, even within same person. This review aims summary impact healthy on human brain, focusing variations from different brain regions cell types. Depending specific regions, exhibits thinning, volume reduction, regional shrinkage, disrupted tissue integrity, decreased complexity, or iron accumulation during aging. Moreover, cells exhibit morphology function changes Neurons undergo characterized by reduced dendrites, dendritic spines, axons less compact myelin sheaths, leading a significant loss synapses. Comparatively, glia often transform into reactive phenotype.

Language: Английский

Regional- and cell type-specific changes of the human brain during aging DOI Creative Commons
Yanxi Chen,

Gaoyu Zu,

Bill Ling Feng Zhang

et al.

Human Brain, Journal Year: 2024, Volume and Issue: 2(3)

Published: Jan. 10, 2024

As individuals age, cognitive decline becomes more prominent, concomitant with an elevated susceptibility to neurodegenerative diseases and dementia. Additionally, symptoms of chronic neuropsychiatric tend worsen age. It is crucial highlight that the aging process does not affect uniformly, its effects can vary, even within same person. This review aims summary impact healthy on human brain, focusing variations from different brain regions cell types. Depending specific regions, exhibits thinning, volume reduction, regional shrinkage, disrupted tissue integrity, decreased complexity, or iron accumulation during aging. Moreover, cells exhibit morphology function changes Neurons undergo characterized by reduced dendrites, dendritic spines, axons less compact myelin sheaths, leading a significant loss synapses. Comparatively, glia often transform into reactive phenotype.

Language: Английский

Citations

1