Laser & Optoelectronics Progress, Journal Year: 2024, Volume and Issue: 61(20), P. 2011021 - 2011021
Published: Jan. 1, 2024
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 20, 2025
Lanthanide-doped upconversion nanoparticles (UCNPs) are emerging as innovative nonlinear probes in biomedical studies, offering the unique capability to simultaneously emit both visible (VIS) and near-infrared (NIR) photons under continuous-wave (CW) NIR excitation. However, deep-tissue high-resolution imaging remains challenging due trade-off between VIS emission (higher resolution, limited penetration) (deeper penetration, lower resolution). Here we present a CW microscopy based on homologous dual-emission adaptive optics, leveraging Tm3+/Yb3+ co-doped UCNPs' dual 455 nm/800 nm emission: 800 for aberration measurement (guide-star) deep tissues at matching depths. Using home-built laser scanning microscope with 975 laser, achieved near-diffraction-limited (480 laterally) 500 μm depth mouse brain environment significant optical aberrations. This strategy expands applications innovates exploration of features.
Language: Английский
Citations
0
Nanophotonics, Journal Year: 2025, Volume and Issue: 14(5), P. 613 - 623
Published: March 1, 2025
Abstract Adaptive optics is a technology that corrects wavefront distortions to enhance image quality. Interferometric focus sensing (IFS), relatively recently proposed method within the field of adaptive optics, has demonstrated effectiveness in correcting complex aberrations deep tissue imaging. This approach determines correction pattern based on single location sample. In this paper, we propose an image-based interferometric (IBIFS) conjugate configuration progressively estimates and over entire view by monitoring feedback quality metrics. The sample allows for multiple points across full sequentially measuring each point. We experimentally demonstrate our both fluorescent beads mouse brain slices using custom-built two-photon microscope. show large effective as well more stable optimization results compared region interest method.
Language: Английский
Citations
0
Laser & Optoelectronics Progress, Journal Year: 2025, Volume and Issue: 62(8), P. 0817002 - 0817002
Published: Jan. 1, 2025
Citations
0
Journal of intelligent medicine., Journal Year: 2024, Volume and Issue: 1(1), P. 42 - 62
Published: Nov. 28, 2024
Abstract Fluorescence imaging (FI) has been instrumental in advancing biological research and enhancing biomedical diagnostics. Despite its widespread applications, FI faces challenges such as efficiently acquiring high signal‐to‐noise ratio (SNR) images, improving spatiotemporal resolution, conducting precise quantitative analysis. Deep learning (DL), which emulates the neural network structure of human brain, excels at from complex data patterns, extracting subtle features, SNR resolution fluorescence images. These advancements significantly elevate quality usability data. Additionally, DL technology is adept handling large datasets efficiently, crucial for accuracy efficiency image This article reviews latest advances application to methodologies their subsequent impact on biology biomedicine. It also explores future possibilities research, providing insights prospects could shape field's trajectory.
Language: Английский
Citations
1
Laser & Optoelectronics Progress, Journal Year: 2024, Volume and Issue: 61(6), P. 0618002 - 0618002
Published: Jan. 1, 2024
基于多模光纤或多芯光纤的无透镜超细光纤内窥成像技术近些年获得了快速发展,有望成为下一代的极微创、高分辨率内窥显微镜。通过对相干入射光场的时空调控,该技术可克服多模光纤中模式色散或多芯光纤中相位畸变的影响,在无需光纤末端透镜或扫描器件的情况下实现高分辨率的聚焦、成像及相关应用。此外,在无透镜光纤内窥成像或图像传输等场景下,通过构建物理或深度学习模型,从光纤输出测量中也能实现物体信息重建。对相干光纤无透镜成像技术的发展进行综述,首先说明无透镜光纤成像的基础原理,并从主动波前调控和被动目标重建这两类角度阐述无透镜光纤成像方法,接着介绍一些先进光纤成像模态和技术,列举光纤成像相关应用,最后分析该领域所面临的挑战,总结并展望其进一步发展方向和应用前景。
Citations
1
Acta Optica Sinica, Journal Year: 2024, Volume and Issue: 44(11), P. 1106005 - 1106005
Published: Jan. 1, 2024
为提高光纤布拉格光栅(FBG)在超声波探测中的灵敏度和复用能力,设计并实现一种基于聚能耦合效应的双斜锥FBG超声波传感装置。首先,利用锥聚能理论与有限元法,分析锥形结构对超声波的聚焦作用。其次,详细讨论双斜锥FBG的结构参数(斜锥锥角、底面直径、高度、倾斜度)对其聚能效果的影响,确定传感装置最优尺寸。最后,制作传感装置并测试其动态特性。结果表明,封装后的双斜锥FBG超声波传感装置在20~130 kHz工作频率范围内可有效提高FBG检测超声波灵敏度。当工作频率增加到50 kHz时,检测幅值提升了约21倍,且传感响应的线性度良好。设计的超声波传感装置可实现双端输出,具有复用性,可应用于钢轨、桥梁等长距离结构的健康监测。
Citations
0
Acta Optica Sinica, Journal Year: 2024, Volume and Issue: 44(14), P. 1426003 - 1426003
Published: Jan. 1, 2024
Citations
0
Laser & Optoelectronics Progress, Journal Year: 2024, Volume and Issue: 61(21), P. 2126001 - 2126001
Published: Jan. 1, 2024
Citations
0
Laser & Optoelectronics Progress, Journal Year: 2024, Volume and Issue: 61(20), P. 2011021 - 2011021
Published: Jan. 1, 2024
Citations
0