Exposure to polycyclic aromatic hydrocarbons and bone mineral density in children and adolescents: results from the 2011–2016 National Health and Nutrition Examination Survey DOI Creative Commons
Peng Zhang, S Z Li, Hao Zeng

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 17, 2025

Identifying factors that hinder bone development in children and adolescents is crucial for preventing osteoporosis. Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked reduced mineral density (BMD), although available data, especially adolescents, are limited. We examined the associations between urinary hydroxylated-PAHs (OH-PAHs) lumbar spine BMD, pelvic total BMD among 8-19 years participants (N = 1,332) of 2011-2016 National Health Nutrition Examination Survey. Weighted linear regressions were employed assess OH-PAHs BMD. Additionally, Bayesian kernel machine regression (BKMR) quantile g-computation (Qgcomp) models utilized investigate effect co-exposure PAHs on Several exhibited negative with adolescents. For instance, an increase one unit natural log-transformed levels 1-hydroxypyrene 2&3-Hydroxyphenanthrene was a decrease -0.014 g/cm2 (95% CI: -0.026, -0.002) -0.018 -0.032, -0.004) -0.021 -0.039, -0.003) -0.017 -0.033, -0.001) -0.013 -0.023, -0.016 -0.006) The body mass index modified revealing effects primarily significant overweight/obese individuals but not underweight/normal individuals. Both BKMR model Qgcomp indicated correlation overall seven Our findings revealed exposure might potentially impacting peak mass-an essential factor influencing lifelong skeletal health.

Language: Английский

Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking DOI Creative Commons
Xiaohong Zhang,

Xi Zhu,

Wenbo Gu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117820 - 117820

Published: Jan. 30, 2025

Language: Английский

Citations

0
Exposure to polycyclic aromatic hydrocarbons and bone mineral density in children and adolescents: results from the 2011–2016 National Health and Nutrition Examination Survey DOI Creative Commons
Peng Zhang, S Z Li, Hao Zeng

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 17, 2025

Identifying factors that hinder bone development in children and adolescents is crucial for preventing osteoporosis. Exposure to polycyclic aromatic hydrocarbons (PAHs) has been linked reduced mineral density (BMD), although available data, especially adolescents, are limited. We examined the associations between urinary hydroxylated-PAHs (OH-PAHs) lumbar spine BMD, pelvic total BMD among 8-19 years participants (N = 1,332) of 2011-2016 National Health Nutrition Examination Survey. Weighted linear regressions were employed assess OH-PAHs BMD. Additionally, Bayesian kernel machine regression (BKMR) quantile g-computation (Qgcomp) models utilized investigate effect co-exposure PAHs on Several exhibited negative with adolescents. For instance, an increase one unit natural log-transformed levels 1-hydroxypyrene 2&3-Hydroxyphenanthrene was a decrease -0.014 g/cm2 (95% CI: -0.026, -0.002) -0.018 -0.032, -0.004) -0.021 -0.039, -0.003) -0.017 -0.033, -0.001) -0.013 -0.023, -0.016 -0.006) The body mass index modified revealing effects primarily significant overweight/obese individuals but not underweight/normal individuals. Both BKMR model Qgcomp indicated correlation overall seven Our findings revealed exposure might potentially impacting peak mass-an essential factor influencing lifelong skeletal health.

Language: Английский

Citations

0